Supramolecular semiquinone radicals confined with DNAzymes for dissipative ROS generation and therapy

Wang, Zhenqiang; Jia, Ruirui; Chen, Yuhua; Xie, Xiyue; Wang, Shuai; Huang, Jing; Zhou, Meizhen; Cai, Kaiyong; Zhang, Jixi

doi:10.1016/j.nantod.2022.101402

Cited by 13 publications

(6 citation statements)

References 48 publications

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“…[27] Meng et al [28] constructed an Sscheme HJ (TiO 2 /PDA) utilizing PDA-modified TiO 2 nanoparticles, which exhibited faster charge carrier transport and more efficient electron-hole separation owing to the strong hydrationdependent conductivity of PDA. Zhang et al [11,29] discovered that PDA-based analogs, which are rich in reducing functional groups such as catechol and imine, exhibit excellent antioxidant properties and are capable of rapidly remove ROS storms after excessive photothermal therapy for tumors, which could effectively prevent immune response damage to normal cells caused by excessive ROS.…”

Section: Introductionmentioning

confidence: 99%

Sulfur Vacancy‐Rich Bi₂S_3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria

Mo,

Pan,

Chen

et al. 2024

Adv Funct Materials

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Antibacterial photocatalytic therapy (APCT) is one of the most promising non‐antibiotic treatment strategies for biofilm‐infected wounds and inflammation caused by drug‐resistant bacteria. However, it still faces issues such as inadequate single antibacterial capacity and lack of antioxidant capacity. In this study, a Z‐scheme heterojunction (Bi2S3‐X@PDA) is designed using a polydopamine (PDA) shell firmly anchored to the surface of sulfur vacancy‐rich bismuth sulfide nanorods (Bi2S3‐X NRs). Under near‐infrared light and hydrogen peroxide, Bi2S3‐X@PDA significantly improves the photocatalytic efficiency of reactive oxygen species generation and shows a nearly 100% broad‐spectrum antibacterial effect against multiple bacterial strains and bacterial biofilms in vitro. Interestingly, the antioxidant activity of the PDA shell in Bi2S3‐X@PDA remarkably downregulates the expression of pro‐inflammatory factors and promotes macrophage reprogramming toward the proregenerative M2 phenotype. In a mouse wound model of methicillin‐resistant Staphylococcus aureus biofilm infection, Bi2S3‐X@PDA effectively eliminates drug‐resistant bacterial biofilms through APCT/mild photothermal therapy, while reducing inflammation in normal tissues and regulating the immune microenvironment, thereby promoting rapid wound healing. Overall, this light‐controlled treatment strategy, which provides both antibacterial and anti‐inflammatory functions, is a reliable tool for combating biofilm infection and inflammation caused by drug‐resistant bacteria.

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Section: Introductionmentioning

confidence: 99%

Sulfur Vacancy‐Rich Bi₂S_3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria

Mo,

Pan,

Chen

et al. 2024

Adv Funct Materials

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“…Therefore, the reversible transformation of phenol-SQ-quinone in PDA films under oxidative stress is closely related to changes in vascular wall cells and inflammatory cells. 14 Na 2 S 2 O 3 has been used as a stabilizer for studying SQ radicals in vitro [15][16][17] and oxidative stress can be simulated through ultraviolet (UV) irradiation of a hydrogen peroxide diluent. 18,19 Therefore, we studied the reversible transformation of phenol-SQ-quinone in PDA films using Na 2 S 2 O 3 to stabilize SQ, and using a hydrogen peroxide diluent and UV irradiation to simulate oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the reversible transformation of phenol-SQ-quinone in PDA films under oxidative stress is closely related to changes in vascular wall cells and inflammatory cells. 14…”

Section: Introductionmentioning

confidence: 99%

Effects of semiquinone-rich surface on the behaviors of vascular cells

Wang

Liu

et al. 2023

J Biomater Appl

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Dopamine has been widely used for surface modification of cardiovascular medical devices as it forms films on most substrates that provide functional groups for surface chemical modification. However, under oxidative stress, the phenolic hydroxyl group on dopamine can undergo reversible transformation into phenol-semiquinone-quinone, which can cause cytotoxicity and immunotoxicity. In this study, we measured the effects of semiquinone on the behavior of vascular wall cells and inflammatory cells under oxidative stress via ultraviolet irradiation with a hydrogen peroxide diluent. Na2S2O3 was used as a stabilizer to obtain a semiquinone-rich poly-dopamine film, then phenol-semiquinone-quinone ratio on its surface was evaluated at three irradiation-oxidation time points. We found that the poly-dopamine film with ultraviolet irradiation in hydrogen peroxide solution for 15 min had the highest semiquinone occupancy of 19.18%. In the experimental group irradiated for 15 min, endothelial cells were cultured statically for 3 days and the number of surface adherent endothelial cells in the group with added semiquinone stabilizer was reduced to 73% of that in the group without stabilizer, indicating that semiquinone rich surface inhibits adhesion and proliferation of endothelial cells; Smooth muscle cells were cultured statically for 3 days, and the number of adherent smooth muscle on surfaces without stabilizer was reduced to 75% of that on surfaces with stabilizer added, indicating that semiquinone rich surfaces promote smooth muscle proliferation. These results demonstrate that semiquinone can adversely affect the repair effect after implantation of cardiovascular materials. Therefore, our study provides a reference for the application and optimization of dopamine in cardiovascular implant materials.

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“…Iron-based hydrogel can also be used for topical treatment, such as wound disinfection [ 94 ] and tendon tissue injury recovery [ 95 ]. What’s more, Fe has a great potential in adjuvant treatment after surgery for malignant tumors [ 96 – 102 ]. For example, with the help of the para-magnetism of Fe ions, under the external magnetic field, heat can be released to achieve the directional killing of tumor cells [ 103 ].…”

Section: Introductionmentioning

confidence: 99%

“…CDT is a new ROS-mediated cancer treatment method based on in situ Fenton reaction in tumor site [ 102 , 119 , 120 ]. In the CDT process, metal ions such as Cu [ 121 ], Fe [ 122 ], Mn [ 123 ], catalyzed excessive endogenous H 2 O 2 in tumor microenvironment (TME) by Fenton or Fenton-like reaction to generate highly toxic •OH [ 124 ], which can specifically cause the death of tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Enhanced postoperative cancer therapy by iron-based hydrogels

Zhang

et al. 2022

Biomater Res

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Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have been widely developed for postoperative adjuvant tumor therapy. Among them, because of the simple synthesis, good biocompatibility, biodegradability, injectability, and multifunctionality, iron-based hydrogels have received extensive attention. This review has summarized the general synthesis methods and construction principles of iron-based hydrogels, highlighted the latest progress of iron-based hydrogels in postoperative tumor therapy, including chemotherapy, photothermal therapy, photodynamic therapy, chemo-dynamic therapy, and magnetothermal-chemical combined therapy, etc. In addition, the challenges towards clinical application of iron-based hydrogels have also been discussed. This review is expected to show researchers broad perspectives of novel postoperative tumor therapy strategy and provide new ideas in the design and application of novel iron-based hydrogels to advance this sub field in cancer nanomedicine.

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Supramolecular semiquinone radicals confined with DNAzymes for dissipative ROS generation and therapy

Cited by 13 publications

References 48 publications

Sulfur Vacancy‐Rich Bi₂S_3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria

Sulfur Vacancy‐Rich Bi₂S_3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria

Effects of semiquinone-rich surface on the behaviors of vascular cells

Enhanced postoperative cancer therapy by iron-based hydrogels

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Supramolecular semiquinone radicals confined with DNAzymes for dissipative ROS generation and therapy

Cited by 13 publications

References 48 publications

Sulfur Vacancy‐Rich Bi2S3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria

Sulfur Vacancy‐Rich Bi2S3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria

Effects of semiquinone-rich surface on the behaviors of vascular cells

Enhanced postoperative cancer therapy by iron-based hydrogels

Contact Info

Product

Resources

About

Sulfur Vacancy‐Rich Bi₂S_3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria

Sulfur Vacancy‐Rich Bi₂S_3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria