2012
DOI: 10.1021/ja3102192
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Supramolecular Sensor for Cancer-Associated Nitrosamines

Abstract: A supramolecular assay based on two fluorescent cucurbit[n]uril probes enables the recognition and quantification of nitrosamines, including cancer-associated nitrosamines, compounds that are difficult to recognize. The cross-reactive sensor leverages weak interactions and competition among the probe, metal, and guest, yielding high information density in the signal output (variance) and enabling the recognition of structurally similar guests.

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Cited by 150 publications
(89 citation statements)
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“…[17] Briefly,S VM is as upervised classification method that seeks to separate classes by mapping the input into an n-dimensional vector space using kernel functions.T he SVM regression method constructs calibration models that serve to predict the ee values of unknown samples.…”
Section: Methodsmentioning
confidence: 99%
“…[17] Briefly,S VM is as upervised classification method that seeks to separate classes by mapping the input into an n-dimensional vector space using kernel functions.T he SVM regression method constructs calibration models that serve to predict the ee values of unknown samples.…”
Section: Methodsmentioning
confidence: 99%
“…[2] More recently, the focus of research in the CB[n] area has shifted toward the preparation of systems with function. For example, the recognition properties of CB[n] have been exploited to create chemical sensing ensembles, [7] molecular machines, [6a] supramolecular materials, [8] perform supramolecular catalysis, [9] and solubilize, formulate, and deliver drugs. [10,11] …”
mentioning
confidence: 99%
“…10 However, direct turn-on fluorescent chemosensors that operate in water or in complex biological milieu such as urine are rare. 11 Aiming to fill this gap, we decided to explore the potential of fluorescent acyclic cucurbituril (aCB) derivatives with a flexible cavity 12 to bind opiate drugs (Figure 1) and their metabolites. The advantage of the aCBs is that they can adapt their flexible cavity to accommodate the drug by an induced fit mechanism, while also binding ammonium ions via ion-dipole interactions and hydrogen bonding to the C=O moieties of the ureidyl portals.…”
Section: Introductionmentioning
confidence: 99%