Supramolecular Transmembrane Channels

Sato, Kohei

doi:10.1002/9783527834044.ch41

Cited by 2 publications

(3 citation statements)

References 78 publications

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“…Before describing the details of the structures and functions of fluorinated nanochannels, the author would like to introduce the basic design strategies of synthetic channels that have been reported previously. The simplest molecular design is a unimolecular channel formed by tubular molecules such as cucurbituril, pillararene, and carbon nanotubes that spans across the lipid bilayer membranes to form transmembrane nanopores. − Other types of synthetic channels are supramolecular channels constructed by the self-assembly of low molecular weight compounds into a tubular structure via noncovalent interactions such as hydrogen bonding, π–π interactions, hydrophobic effect, etc . Typical examples include macrocyclic compounds and helical foldamers that self-assemble on top of each other or rod-shaped molecules that interact with each other in a lateral fashion to form supramolecular nanochannels.…”

Section: Designing Synthetic Channelsmentioning

confidence: 99%

“…26−28 Other types of synthetic channels are supramolecular channels constructed by the self-assembly of low molecular weight compounds into a tubular structure via noncovalent interactions such as hydrogen bonding, π−π interactions, hydrophobic effect, etc. 29 Typical examples include macrocyclic compounds and helical foldamers that self-assemble on top of each other or rod-shaped molecules that interact with each other in a lateral fashion to form supramolecular nanochannels. In general, channel-forming molecules possess a hydrophobic surface that shows a high affinity for the hydrophobic interior of lipid bilayer membranes, allowing them to effectively localize within the membranes.…”

Section: ■ Introductionmentioning

confidence: 99%

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Beyond Natural Channel Proteins: Recent Advances in Fluorinated Nanochannels

Sato

2024

Langmuir

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Inspired by the structures and functions of natural channel proteins that selectively permeate ions and molecules across biological membranes, synthetic molecules capable of self-assembling into supramolecular nanotubes within the hydrophobic layer of the membranes have been designed and their material permeation properties have been studied. More recently, synthetic chemists have ventured to incorporate fluorine atoms, elements rarely found in natural proteins, into the structure of synthetic channels and discovered anomalous transmembrane material permeation properties. In this Perspective, the author provides a brief overview of recent advances in the development of fluorinated nanochannels and possible directions for the future.

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Section: Designing Synthetic Channelsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Beyond Natural Channel Proteins: Recent Advances in Fluorinated Nanochannels

Sato

2024

Langmuir

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“…Within this context, synthetic ion channels can be categorized into two types: unimolecular channels and supramolecular assembled channels. 109,110 The unimolecular channels are formed by a large covalently bonded molecule, and the supramolecular assembled channels are comprised of smaller subunits through noncovalent interactions between molecules. 106 Both channels possess a high degree of control.…”

Section: Biomimetic Membranesmentioning

confidence: 99%

Ion–Ion Selectivity of Synthetic Membranes with Confined Nanostructures

Liu,

Epsztein,

Lin

et al. 2024

ACS Nano

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Synthetic membranes featuring confined nanostructures have emerged as a prominent category of leading materials that can selectively separate target ions from complex water matrices. Further advancements in these membranes will pressingly rely on the ability to elucidate the inherent connection between transmembrane ion permeation behaviors and the ion-selective nanostructures. In this review, we first abstract state-of-the-art nanostructures with a diversity of spatial confinements in current synthetic membranes. Next, the underlying mechanisms that govern ion permeation under the spatial nanoconfinement are analyzed. We then proceed to assess ion-selective membrane materials with a focus on their structural merits that allow ultrahigh selectivity for a wide range of monovalent and divalent ions. We also highlight recent advancements in experimental methodologies for measuring ionic permeability, hydration numbers, and energy barriers to transport. We conclude by putting forth the future research prospects and challenges in the realm of high-performance ion-selective membranes.

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Supramolecular Transmembrane Channels

Cited by 2 publications

References 78 publications

Beyond Natural Channel Proteins: Recent Advances in Fluorinated Nanochannels

Beyond Natural Channel Proteins: Recent Advances in Fluorinated Nanochannels

Ion–Ion Selectivity of Synthetic Membranes with Confined Nanostructures

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