Supramolecular “Trojan Horse” for Nuclear Delivery of Dual Anticancer Drugs

Cai, Yanbin; Shen, Haosheng; Zhan, Jie; Lin, Mingliang; Dai, Liuhan; Ren, Chunhua; Shi, Yang; Liu, Jianfeng; Gao, Jie; Yang, Zhimou

doi:10.1021/jacs.6b12322

Cited by 275 publications

(169 citation statements)

References 35 publications

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“…Low-molecular-weight amphiphiles derived from amino acids, glucose, and glucosamine have been used as biomaterials, [23][24][25] chirality detectors, 26,27 and chiral material preparation. 28,29 N-Palmitoyl glucosamine is soluble in N, N-dimethylformamide, dimethyl sulfoxide, toluene, and chloroform at room temperature.…”

Section: Resultsmentioning

confidence: 99%

Left‐handed helical polymer resin nanotubes prepared by using N‐palmitoyl glucosamine

et al. 2017

Chirality

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Although the preparation of single-handed helical inorganic and hybrid organic-inorganic nanotubes is well developed, approaches to the formation of single-handed organopolymeric nanotubes are limited. Here, left-handed helical m-phenylenediamine-formaldehyde resin and 3-aminophenol-formaldehyde resin nanotubes were prepared by using N-palmitoyl glucosamine that can self-assemble into left-handed twisted nanoribbons in a mixture of methanol and water. In the reaction mixture, the helical pitch of the nanoribbons decreased with increasing reaction time. The resin nanotubes were obtained after removing the N-palmitoyl glucosamine template, and circular dichroism spectroscopy indicated that the organopolymeric nanotubes had optical activity. Carbonaceous nanotubes were then prepared by carbonization of the 3-aminophenol-formaldehyde resin nanotubes.

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Section: Resultsmentioning

confidence: 99%

Left‐handed helical polymer resin nanotubes prepared by using N‐palmitoyl glucosamine

et al. 2017

Chirality

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“…Therefore, intranuclear delivery and accumulation of different kinds of drugs with no overlapping toxicities are supposed to generate an additive therapeutic outcome. To this end, Yang and co‐workers developed supramolecular nanomedicines by a simple self‐assembly strategy to deliver dual synergistic anticancer drugs into cell nucleus ( Figure a) . Specifically, the 10‐hydroxycamptothecine (HCPT) (a DNA‐topoisomerase I inhibitor) was conjugated with a peptide sequence (FFERGD) to generate the negative HCPT‐peptide (HP) amphiphile, which was subsequently coassembled with another drug cisplatin (forming interstrand DNA crosslinks) through chelating with peptide.…”

Section: Therapeutic Strategies Toward Specific Subcellular Compartmentsmentioning

confidence: 99%

Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials

2018

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Recently, diverse functional materials that take subcellular structures as therapeutic targets are playing increasingly important roles in cancer therapy. Here, particular emphasis is placed on four kinds of therapies, including chemotherapy, gene therapy, photodynamic therapy (PDT), and hyperthermal therapy, which are the most widely used approaches for killing cancer cells by the specific destruction of subcellular organelles. Moreover, some non-drug-loaded nanoformulations (i.e., metal nanoparticles and molecular self-assemblies) with a fatal effect on cells by influencing the subcellular functions without the use of any drug molecules are also included. According to the basic principles and unique performances of each treatment, appropriate strategies are developed to meet task-specific applications by integrating specific materials, ligands, as well as methods. In addition, the combination of two or more therapies based on multifunctional nanostructures, which either directly target specific subcellular organelles or release organelle-targeted therapeutics, is also introduced with the intent of superadditive therapeutic effects. Finally, the related challenges of critical re-evaluation of this emerging field are presented.

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“…The resulting supramolecular nanodrugs could deliver both drugs more efficiently and showed synergistic effects indicated by the combination index. The reciprocal relationship of these two drugs could even inhibit drug resistant cancer cells in vivo …”

Section: Eisa‐facilitating Drug Deliverymentioning

confidence: 99%

Enzyme‐Instructed Supramolecular Self‐Assembly with Anticancer Activity

et al. 2018

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Cancer remains one of the leading causes of death, which has continuously stimulated the development of numerous functional biomaterials with anticancer activities. Herein is reviewed one recent trend of biomaterials focusing on the advances in enzyme‐instructed supramolecular self‐assembly (EISA) with anticancer activity. EISA relies on enzymatic transformations to convert designed small‐molecular precursors into corresponding amphiphilic residues that can form assemblies in living systems. EISA has shown some advantages in controlling cell fate from three aspects. 1) Based on the abnormal activity of specific enzymes, EISA can differentiate cancer cells from normal cells. In contrast to the classical ligand–receptor recognition, the targeting capability of EISA relies on dynamic control of the self‐assembly process. 2) The interactions between EISA and cellular components directly disrupt cellular processes or pathways, resulting in cell death phenotypes. 3) EISA spatiotemporally controls the distribution of therapeutic agents, which boosts drug delivery efficiency. Therefore, with regard to the development of EISA, the aim is to provide a perspective on the future directions of research into EISA as anticancer theranostics.

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Supramolecular “Trojan Horse” for Nuclear Delivery of Dual Anticancer Drugs

Cited by 275 publications

References 35 publications

Left‐handed helical polymer resin nanotubes prepared by using N‐palmitoyl glucosamine

Left‐handed helical polymer resin nanotubes prepared by using N‐palmitoyl glucosamine

Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials

Enzyme‐Instructed Supramolecular Self‐Assembly with Anticancer Activity

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