Supranodose vagotomy precludes reflex respiratory responses to serotonin in cats

Kopczyńska, Beata; Szereda-Przestaszewska, Małgorzata

doi:10.1007/bf02256323

Cited by 11 publications

(6 citation statements)

References 23 publications

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“…Since intravenous serotonin does not penetrate the blood-brain barrier, the nodose ganglia are considered to be a primary target of its action. This view is supported by the observation that the apneic response to serotonin was virtually abolished after bilateral supranodose vagotomy in the present and previous studies (Jacobs and Comroe, 1971; Segers and Shannon, 1985; Yoshioka et al, 1992a and b; Kopczynska and Szereda-Przestaszewska, 2003). …”

Section: Discussionsupporting

confidence: 89%

Impact of the vagal feedback on cardiorespiratory coupling in anesthetized rats

Topchiy

Radulovački

Waxman

et al. 2011

Respiratory Physiology & Neurobiology

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Cardiorespiratory coupling can be significantly influenced by both pontine and vagal modulation of medullary motor and premotor areas. We investigated influences of the pontine intertrigeminal region (ITR) and peripheral vagal pathways on the coupling between systolic blood pressure (SBP) and respiration in 9 anesthetized rats. Glutamate injection into the ITR perturbed both respiration and SBP and decreased SBP-respiratory coherence (0.95±0.01 vs 0.89±0.02; (p=0.01). Intravenous infusion of serotonin (5-HT) produced apnea and hypertension and also decreased SBP-respiratory coherence (0.95±0.01 vs 0.72±0.06; p=0.04). Bilateral vagotomy eliminated the cardiorespiratory coherence perturbations induced by central (glutamate injection into the ITR: 0.89±0.03 vs 0.86±0.03; p=0.63) and peripheral (5-HT infusion: 0.89±0.03 vs 0.88±0.02; p=0.98) pharmacologic manipulations. Glutamate stimulation of the ITR postvagotomy increased the relative spectral power density of SBP in the respiratory frequency range (0.25±0.08 vs 0.55±0.06; p=0.01). The data suggest that SBP-respiratory coupling is largely mediated within the central nervous system, with vagal systems acting in a way that disrupts coherence during transient cardiorespiratory disturbances. Although decreased cardiorespiratory coherence may increase cardiac work during perturbations, this may be physiologically advantageous in restoring homeostatic equilibrium of respiration and blood pressure.

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Section: Discussionsupporting

confidence: 89%

Impact of the vagal feedback on cardiorespiratory coupling in anesthetized rats

Topchiy

Radulovački

Waxman

et al. 2011

Respiratory Physiology & Neurobiology

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show abstract

“…For example, injection of serotonin into the pulmonary circulation of cats elicits a pulmonary chemoreflex, which is a cascade of cardiorespiratory responses that include apnea, hypotension and bradycardia, followed by rapid shallow breathing [8]. The study by Kopczynska and Szereda-Przestaszewska [18] extends this previous work, and they found that pulmonary vagal afferents and nodose ganglion contribute to the serotonin-induced ventilatory effects.…”

Section: Supranodose Vagotomy Precludes Reflex Respiratory Responses supporting

confidence: 70%

Biomedical Vignette

2003

J Biomed Sci

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“…In our experimental paradigm the mediation may occur via serotonergic system on the vagal afferents to the brain stem. Damage to sections of the supranodose serotonergic pathway results in a moderate, significant increase in arterial blood pressure in rats and cats (Orer et al, 1991;Kopczyńska and Szereda-Przestaszewska, 2003), which supports the latter explanation.…”

Section: Discussionsupporting

confidence: 58%

“…It should be mentioned that bilateral vagotomy performed in cats at the supranodose level shows similar effectiveness to MDL in precluding post-serotonin respiratory responses (Kopczyńska and Szereda-Przestaszewska, 2003). Bearing on the fact that feline nodose ganglia contain a great amount of 5HT 3 receptors (Zhou et al, 1997), they emerge at the first line in modeling the respiratory response to serotonin.…”

Section: Discussionmentioning

confidence: 98%