Supranumerary optic disc vessels may indicate reduced systemic angiogenesis in Down syndrome

Diagnosing papillorenal syndrome: see the optic papilla

“…Therefore, deficiency in systemic angiogenesis can produce renal hypoplasia; disturb ureteric branching, morphogenesis and elongation; and perturb the microvessel density of the distal ureter and the angle of insertion of the ureter into the bladder, resulting in vesicoureteral reflux (VUR) [8,9]. Such shared angiogenic and tubular budding pathways provide mechanistic links that explain and predict various oculorenal disorders, such as von Hippel-Lindau disease and Down syndrome [10].…”

Macular structural characteristics in children with Down syndrome

“…Despite the obvious ocular problems, in light of the unique challenges of retinal imaging in children, there are few reports on retinal structure in children with Down syndrome. We occasionally see case reports on Down syndrome children with bilateral macular coloboma [25], optic disc elevation, or other retinal abnormalities [26][27][28]. Although there are published reports discussing these issues, much of the current data are considerably variable.…”

Unilateral morning glory optic disc anomaly in a case with Down syndrome

“…Optic disc and optic disc vessels anomalies have been described in association with DS [10-12]. Number of retinal vessels crossing the disc optic margin in the patients with DS is increased (40%) when compared to a normal population (6%) [10].…”