Suprarenal Neuroblastoma Presenting in a Child With Infantile Scoliosis

Nakazawa, Mary; Crook, Shannon; Horan, Jessica; D’Orazio, John A.

doi:10.1002/pbc.25835

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…However, patients with neuroblastoma typically present with an asymptomatic mass or symptoms secondary to the location of the mass rather than symptoms of excess catecholamines [ 46 ]. This can include constipation from bowel compression, hypertension from renal artery compression, and scoliosis with or without neurosensory and motor symptoms from spinal cord compression [ 47 , 48 , 49 , 50 ]. Neuroblastomas are heterogenous with courses ranging from benign to very aggressive.…”

Section: Diagnosismentioning

confidence: 99%

Pediatric Neuroendocrine Neoplasms: Rare Malignancies with Incredible Variability

Castle

Levy

Chauhan

2022

Cancers

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Neuroendocrine neoplasms (NENs) encompass a variety of neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) which can arise anywhere in the body. While relatively rare in the pediatric population, the incidence of NENs has increased in the past few decades. These neoplasms can be devastating if not diagnosed and treated early, however, symptoms are variable and can be indolent for many years. There is a reported median of 10 years from the appearance of the first symptoms to time of diagnosis. Considering some of these neoplasms have a mortality rate as high as 90%, it is crucial healthcare providers are aware of NENs and remain vigilant. With better provider education and easily accessible resources for information about these neoplasms, awareness can be improved leading to earlier disease recognition and diagnosis. This manuscript aims to provide an overview of both the most common NENs as well as the rarer NENs with high lethality in the pediatric population. This review provides up to date evidence and recommendations, encompassing recent changes in classification and advances in treatment modalities, including recently completed and ongoing clinical trials.

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Section: Diagnosismentioning

confidence: 99%

Pediatric Neuroendocrine Neoplasms: Rare Malignancies with Incredible Variability

Castle

Levy

Chauhan

2022

Cancers

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Treatment of scoliosis in children after resection of neuroblastoma—A report of five cases

Xu,

Zou,

Zhang

et al. 2024

Journal of Children's Orthopaedics

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Purpose: Neuroblastoma (NB) is a common extracranial solid tumor in children, often requiring surgical resection. Post-resection NB near the spine can lead to spinal deformities, but treatment strategies are not well-documented. Methods: We retrospectively reviewed our patients who developed spinal deformities after NB resection at our hospital from 2013 to 2021. Treatment included the traditional growing rod (TGR) technique for patients with growth potential, posterior spinal fusion (PSF) for skeletally mature patients, and intermittent cast therapy for infants. Results: Five female patients underwent chemotherapy and surgical resection for NB, with no recurrence during follow-up. Single curves were seen in Cases 1, 2, 4, and 5, and Case 3 had double curves. NB tumors were on the convex side in Cases 1, 3, and 5, and on the concave side in Cases 2 and 4. TGR was used for Cases 1 and 2 due to growth potential and inadequate height. PSF was chosen for Cases 3 and 4, achieving satisfactory scoliosis and kyphosis correction. Case 5, diagnosed with scoliosis at 16 months, underwent intermittent cast therapy for 2 years, significantly correcting scoliosis and avoiding surgery. The average time from NB resection to scoliosis onset was 65.2 ± 49.3 months, with scoliosis treatment starting at 82.6 ± 58.1 months. The mean follow-up was 38.2 ± 12.1 months. All patients showed significant improvement in spinal deformities, with no significant correction loss at the last follow-up. Conclusions: After NB resection, spinal deformities should be closely monitored, with intervention preferably within 6 months of discovery. TGR, PSF, and casting are effective interventions, with the treatment modality based on the patient's skeletal maturity and height.

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Suprarenal Neuroblastoma Presenting in a Child With Infantile Scoliosis

Cited by 2 publications

References 9 publications

Pediatric Neuroendocrine Neoplasms: Rare Malignancies with Incredible Variability

Pediatric Neuroendocrine Neoplasms: Rare Malignancies with Incredible Variability

Treatment of scoliosis in children after resection of neuroblastoma—A report of five cases

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