Background: Shoulder dislocation is one of the commonest joint dislocation and choosing the proper and best method for sedation and analgesia when reduction is performed is important. The routine methods used for treating the shoulder are procedural sedation and analgesia (PSA) and the nerve block. In this study, we aimed to compare the effectiveness of these two above methods, length of emergency department stay, the rate of success, the satisfaction of the physician and the patient, and the complications caused by each of them. Material and Methods: In this clinical trial, 200 patients who were admitted to the emergency department of Hafte Tir and Rasoul-e-Akram Hospitals during 2018 to 2019, were randomly assigned to receive PSA or ultrasound guided suprascapular nerve blocking. Data was collected, recorded and analyzed by SPSS v.22 software. Results: The average of age was 46.55 years and 63% of patients were male. In the nerve block group, 66% of the cases were failed and need to be placed in the PSA method. The duration of reduction was less in PSA method (p<0.05). Also in the PSA group, the length of ED stay was significantly shorter than the nerve block group (p<0.05). The report of patients about pain severity in the time of reduction was markedly lower than the nerve block method (p<0.05). The complications of PSA method such as apnea and hypotension were seen in 35% of patients, whereas, only 6% in nerve block group were suffered from local hematoma and other minor complications. Conclusion: Based on our results, the suprascapular nerve blocking is not a suitable method for shoulder reduction in ED but it can be considered as an alternative and auxiliary method. This method can be considered for high-risk patients, such as a patient with advanced age and cardiovascular disease.