Suprascapular nerve neuropathy leads to supraspinatus tendon degeneration

Sun, Yucheng; Wang, Chuanbing; Kwak, Jae-Man; Jung, Hui-won; Kholinne, Erica

doi:10.1016/j.jos.2019.09.020

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…5 Sun et al evaluated the histomorphology of the brocartilage area of bone-tendon junction formation in a rodent model and reported that there was less cellularity and cell maturity in the group with SN transection. 25 The present study showed that regenerated enthesis with SN injury was relatively more mature in the ADSC (+) group compared to that in the ADSC (-) group, with signi cant improvements in both biomechanical and histological parameters. We postulate the following two possibilities: ADSCs lead to enthesis healing and then, transmission of suitable biomechanical stimulation via this healed enthesis secondarily caused recovery of the damaged nerve and muscles; alternatively, ADSCs lead to enthesis healing, and extra-articular recruitment of ADSCs to the SN simultaneously improved this damaged nerve.…”

Section: Discussionsupporting

confidence: 47%

The effects of adipose-derived stem cell transplantation on tendon-bone healing in a model of chronic rotator cuff tear with suprascapular nerve injury

Eshima

Ohzono

Gotoh

et al. 2022

Preprint

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Background Recurrence of massive rotator cuff tears (RCTs) are relatively common due to resultant muscle atrophy and fatty infiltration, possibly caused by scapular nerve (SN) injury. Growing evidence suggests that adipose-derived stem cells (ADSCs) are useful tools for regeneration in chronic RCT models. However, data on the effects of ADSCs on in chronic RCT models with SNI are limited. This study aimed to investigate the effect of ADSCs on tendon-bone healing in a chronic rotator cuff tear (RCT) model with scapular nerve (SN) injury. Methods Overall, 36 adult rats (weight = 344 ± 33 g) were equally divided into the ADSC (+) and ADSC (-) group. Both groups underwent right shoulder surgery in which the supraspinatus was detached, and SN injury was induced; he untreated left shoulder in the ADSC (-) group was used as a control. In the ADSC (+) group, abdominal fat was collected to culture ADSCs. At 6 weeks postoperatively, the ADSC (+) group underwent surgical tendon repair with ADSC injection, whereas the ADSC (-) group underwent tendon repair with saline injection. Shoulders were harvested at 10, 14, and 18 weeks and underwent histological, fluorescent, and biomechanical analyses. Results In bone-tendon junction, a firm enthesis, including dense mature fibrocartilage and well-aligned cells, was observed in the ADSC (+) group. Conversely, decreased cell density and immature fibrocartilage were observed in the ADSC (-) group. Fatty infiltration was more uncommon in the ADSC (+) group compared to that in the ADSC (-) group. The mean maximum stress and linear stiffness was higher in the ADSC (+) group than in the ADSC (-) group at 18 weeks. Neither the mean Young’s modulus nor the cross-sectional area were significantly different throughout the study. Conclusion ADSC injection produced better histological and biomechanical outcomes. Thus, ADSC supplementation showed a positive effect on tendon-bone healing in a chronic RCT model with SN injury; therefore, ADSC injection possibly accelerates recovery in large RCT repair.

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Section: Discussionsupporting

confidence: 47%

The effects of adipose-derived stem cell transplantation on tendon-bone healing in a model of chronic rotator cuff tear with suprascapular nerve injury

Eshima

Ohzono

Gotoh

et al. 2022

Preprint

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show abstract

“…15 Another study, also in a rodent model, evaluated the histomorphology of the fibrocartilage area of bonetendon junction formation and reported that there was less cellularity and cell maturity in the group with suprascapular nerve transection. 14 We found that regenerated enthesis with suprascapular nerve injury was relatively more mature in the ADC (þve) group compared with the ADC (Àve) group, with significant improvements in both biomechanical and histological parameters. We suggest that ADCs promote enthesis healing and transmission of suitable biomechanical stimulation via the healed enthesis secondarily results in recovery of the damaged nerve and muscles.…”

Section: Discussionmentioning

confidence: 70%

“…13 As aforementioned, reports have shown that suprascapular nerve injury due to massive tears is closely associated with the development of fatty infiltration and/or muscle atrophy. 5,6,14,15 We hypothesized that the administration of adipose-derived cells (ADCs) would reverse fatty infiltration and enhance tendon-bone healing. 16 To investigate this, we established a rodent model of chronic RCT with suprascapular nerve injury to mimic a clinical setting, and assessed the effects of ADC supplementation.…”

Section: Introductionmentioning

confidence: 99%

Effects of adipose-derived cell supplementation on tendon-bone healing in a rat model of chronic rotator cuff tear with suprascapular nerve injury

Eshima,

Ohzono,

Gotoh

et al. 2024

J Int Med Res

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Objective To investigate the effect of adipose-derived cells (ADCs) on tendon-bone healing in a rat model of chronic rotator cuff tear (RCT) with suprascapular nerve (SN) injury. Methods Adult rats underwent right shoulder surgery whereby the supraspinatus was detached, and SN injury was induced. ADCs were cultured from the animals’ abdominal fat. At 6 weeks post-surgery, the animals underwent surgical tendon repair; the ADC (+ve) group (n = 18) received an ADC injection, and the ADC (−ve) group (n = 18) received a saline injection. Shoulders were harvested at 10, 14, and 18 weeks and underwent histological, fluorescent, and biomechanical analyses. Results In the ADC (+ve) group, a firm enthesis, including dense mature fibrocartilage and well-aligned cells, were observed in the bone-tendon junction and fatty infiltration was less than in the ADC (−ve) group. Mean maximum stress and linear stiffness was greater in the ADC (+ve) compared with the ADC (−ve) group at 18 weeks. Conclusion ADC supplementation showed a positive effect on tendon-bone healing in a rat model of chronic RCT with accompanying SN injury. Therefore, ADC injection may possibly accelerate recovery in massive RCT injuries.

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“…In addition, PNS causes stimulation of Aβ nerve fibers, which blocks nociceptive information from the Aδ and C fibers [14,62]. This may be linked to the control of pain perception and also to the optimization of muscle function [14,62,63], taking into account the relationship between the suprascapular nerve and rotator cuff tendinopathy [64][65][66].…”

Section: Discussionmentioning

confidence: 99%

Structural and Functional Changes in Supraspinatus Tendinopathy through Percutaneous Electrolysis, Percutaneous Peripheral Nerve Stimulation and Eccentric Exercise Combined Therapy: A Single-Blinded Randomized Clinical Trial

Góngora-Rodríguez,

Rosety-Rodríguez,

Rodríguez-Almagro

et al. 2024

Biomedicines

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Shoulder tendinopathies produce pain and reduce functionality. The aim of this randomized clinical trial was to analyze the effects of Percutaneous electrolysis (PE), Percutaneous peripheral Nerve Stimulation (PNS) and eccentric exercise (EE) on pain (NPRS), strength, electromyographic activity, ultrasound characteristics of the tendon (echogenicity, thickness and hypervascularization) and functionality (DASH and SPADI) in individuals with supraspinatus tendinopathy. Participants (n = 50) were divided into two groups; they received 4 treatment sessions, 1 per week, of PE and PNS (n = 25) or 10 treatment sessions of TENS and US (n = 25). Both groups performed the EE program consisting of 3 sets of 10 repetitions of each of the 3 exercises, twice a day, during the 4 weeks. Follow-up was carried out at 4, 12 and 24 weeks after the start of the intervention. There are statistically significant differences in the analysis between groups (p < 0.001) in the post-treatment and follow-up measurements favorable to the PE+PNS+EE treatment on pain (NPRS), strength, supraspinatus electromyographic amplitude, ultrasound characteristics of the tendon (echogenicity, thickness and hypervascularization) and DASH and SPADI questionnaires. The combined treatment with PE, PNS and EE is an effective option in the clinical management of tendinopathies, with positive results in the short and long term on the variables studied.

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Suprascapular nerve neuropathy leads to supraspinatus tendon degeneration

Cited by 6 publications

References 32 publications

The effects of adipose-derived stem cell transplantation on tendon-bone healing in a model of chronic rotator cuff tear with suprascapular nerve injury

The effects of adipose-derived stem cell transplantation on tendon-bone healing in a model of chronic rotator cuff tear with suprascapular nerve injury

Effects of adipose-derived cell supplementation on tendon-bone healing in a rat model of chronic rotator cuff tear with suprascapular nerve injury

Structural and Functional Changes in Supraspinatus Tendinopathy through Percutaneous Electrolysis, Percutaneous Peripheral Nerve Stimulation and Eccentric Exercise Combined Therapy: A Single-Blinded Randomized Clinical Trial

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