Background and Purpose. Suprascapular neuropathy, resulting in shoulder pain and weakness, is frequently misdiagnosed. The consequences of misdiagnosis can include inappropriate physical rehabilitation or surgical procedures. The purpose of this case report is to describe the differential diagnosis of suprascapular neuropathy. Case Descriptions. Five patients were initially diagnosed with subacromial impingement syndrome and referred for physical therapy. Physical therapist examination findings were consistent with subacromial impingement syndrome and suprascapular neuropathy. Subsequent electrophysiologic testing confirmed the diagnosis of suprascapular neuropathy in all 5 patients. Discussion. The differential diagnosis of patients with suprascapular neuropathy includes subacromial impingement syndrome, rotator cuff pathology, C5-6 radiculopathy, and upper trunk brachial plexopathy. The diagnostic process and a S uprascapular neuropathy (SSN) may be overlooked or mistaken for other conditions such as subacromial impingement syndrome (SAIS), rotator cuff injury, cervical radiculopathy, or brachial plexopathy. [1][2][3][4][5][6] The signs and symptoms of SSN include shoulder weakness, atrophy, and diffuse aching or burning pain at the shoulder, which often includes the posterolateral aspect of the shoulder in the region of the scapula. [1][2][3][4][5]7 However, painless cases, which involved denervation of the infraspinatus muscle only, also have been reported. 8 Although SSN is uncommon, it should be considered in the differential diagnosis of patients with shoulder pain and weakness. [1][2][3][4][5]7 Suprascapular neuropathy has been reported in 10 patients (0.4%) in a series of 2,520 patients with shoulder pain, 6 but some authors 7 have speculated that this condition is so frequently misdiagnosed that it is probably the cause in 1% to 2% of patients with shoulder pain. Of 10 patients with SSN reported by Post and Mayer, 6 8 patients were initially misdiagnosed, leading to inappropriate intervention. Two patients were managed surgically for SAIS with acromioplasty, 1 patient was managed surgically with C4 -5 diskectomy, 3 patients were managed with cervical traction, 1 patient was managed with a cervical soft collar, and 1 patient was managed for acromioclavicular joint sprain. Six of the 10 patients were managed with unspecified physical therapy interventions. In a later case series of 39 patients with SSN, 18 patients were managed with 30 inappropriate surgical procedures for SAIS, the cervical spine, and thoracic outlet syndrome. 5 In another series of 27 patients, 6 patients underwent surgical procedures for thoracic outlet syndrome and 3 patients underwent cervical diskectomies without relief prior to their diagnosis of SSN. 3 The suprascapular nerve is a mixed motor and sensory nerve arising from the upper trunk of the brachial plexus with contributions primarily from the anterior primary rami of the C5 and C6 nerve roots. It then courses posteroinferiorly beneath the superior transverse scapular lig...