Suprasellar germinoma: radiation therapy.

Fields, Joseph N.; Fulling, Keith H.; Thomas, P.; Marks, Joe

doi:10.1148/radiology.164.1.3108955

Cited by 49 publications

(11 citation statements)

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“…There is no agreement on the optimal radiation dose for the whole brain, but most investigators have applied doses of 25-30 Gy to eradicate microscopic disease. 8,[37][38][39] Shibamoto recommended a low-dose craniospinal irradiation (20 -24 Gy) for patients with positive or negative CSF cytology. 9 There have been no recent reports showing that treatment outcome after high-dose radiation at doses of Ͼ 30 Gy for the whole brain is superior to that of low-dose radiation at Ͻ 30 Gy, and thus it has been suggested that low-dose radiation at Ͻ 30 Gy should be used for the whole brain.…”

Section: Discussionmentioning

confidence: 99%

“…9 There have been no recent reports showing that treatment outcome after high-dose radiation at doses of Ͼ 30 Gy for the whole brain is superior to that of low-dose radiation at Ͻ 30 Gy, and thus it has been suggested that low-dose radiation at Ͻ 30 Gy should be used for the whole brain. 8,[37][38][39] New treatment strategies, including chemotherapy alone without radiotherapy or combined local irradiation with systemic chemotherapy, have been performed to avoid radiation-induced brain damage. 16,17,22,40,41 Allen conducted a Phase II study that was designed to selectively reduce the radiation dose in patients showing a complete response to neoadjuvant carboplatin.…”

Section: Discussionmentioning

confidence: 99%

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Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma

Shikama

Ogawa

Tanaka

et al. 2005

Cancer

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Two dicarboxylic acids (maleic acid and tartaric acid) were used in conjunction with DMDHEU as the crosslinking agents to treat cotton fabric samples. The treated fabrics then were dyed with direct red 81. The results show that the values of the dye absorption, equilibrium absorption, rate constants, and the pore index of structural diffusion resistance constant for the various crosslinking agents are ranked as DMDHEU‐tartaric acid > DMDHEU‐maleic acid > DMDHEU alone at the same dyeing temperature. The activation energies for the three crosslinked fabrics are in the rank of DMDHEU > DMDHEU‐maleic acid > DMDHEU‐tartaric acid. The CL length values for the various crosslinking agent systems are in the series of DMDHEU‐tartaric acid > DMDHEU‐maleic acid > DMDHEU alone for a given number of CL/AGU. The values of the pore index of structural diffusion resistance constant and dyeing rate constant are increased with the increase of CL length. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 97: 143–148, 2005

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma

Shikama

Ogawa

Tanaka

et al. 2005

Cancer

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“…Several authors report favourable results following CSI in children who present with CNS GCT beyond puberty where late morbidity would be acceptable [6,9,16,21,[27][28][29]. Most favour low dose CSI [13,16,22,23,[30][31][32].…”

Section: Cranio-spinal Irradiation (Csi)mentioning

confidence: 99%

“…When compared to smaller radiation therapy fields, WBRT was shown to provide better results in one centre where CT scan and MRI were not routinely available [37]. Others have also reported more favourable results following WBRT [24,28,37,47]. Some have quoted intracranial recurrence rates of up to 15% when full cranial irradiation was not utilised [24,48,49].…”

Section: Local Field Irradiationmentioning

confidence: 99%

Germ cell tumours of the central nervous system in children—controversies in radiotherapy

Borg¹

2003

Med. Pediatr. Oncol.

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The excellent outcome in children with pure germinoma of the CNS and the long-term morbidity associated with standard therapy justifies attempts to limit both the total radiation dose and field sizes, with or without the addition of chemotherapy. The poorer outcome associated with non-germinoma GCT justifies a more aggressive approach in children, combining chemotherapy, surgery and virgule, or radiation therapy, based on known prognostic factors.

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“…Doses of primary site irradiation in most series have ranged between 4,000 and 5,500 cGy [32][33][34][35][36][37][38][39][40][41]. Some studies have suggested poorer survival if doses lower than 4,000 cGy of radiation are delivered to the primary site [1,40] (Table 3).…”

Section: Management: Germinomasmentioning

confidence: 99%

Intracranial Germ Cell Tumors

Takakura¹

1998

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Intracranial germ cell tumors are a heterogeneous group of lesions which occur in children and adults. Within the classification of intracranial germ cell tumors, there are a variety of different tumor types which carry different prognoses. The diagnosis of an intracranial germ cell tumor usually requires histological information, but a subgroup of tumors will secrete specific tumor markers, including α-fetoprotein and β-human chorionic gonadotropin, which may obviate the need for surgical intervention.The management of intracranial germ cell tumors in both children and adults remains unsettled. Germinomas have a good prognosis, as over 90% of patients can be effectively treated with radiation therapy. The dose and volume of radiation therapy needed for disease control is not well established, and controversy exists concerning the need for whole brain or craniospinal radiation therapy for localized tumors. Germinomas are also chemosensitive and recent reports suggest that the dose and volume of radiation therapy required for disease control can be lessened with the addition of adjuvant chemotherapy.The outcome for patients with nongerminomatous germ cell tumors is less favorable. Radiation therapy alone will result in disease control in 40%-60% of patients. The addition of chemotherapy to radiation therapy may improve the rate of survival. The Oncologist 2000;5:312-320

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Suprasellar germinoma: radiation therapy.

Cited by 49 publications

References 0 publications

Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma

Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma

Germ cell tumours of the central nervous system in children—controversies in radiotherapy

Intracranial Germ Cell Tumors

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