Supratentorial extraventricular ependymal neoplasms

Shuangshoti, Shanop; Rushing, Elisabeth J.; Mena, Hernando; Olsen, Cara; Sandberg, Glenn D.

doi:10.1002/cncr.21111

Cited by 79 publications

(85 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We have shown that higher Ki67-li correlated with WHO grade III, in concordance with a previous study in a cohort of adult ependymoma [1], with grade predicting outcome [14][15][16]. This supports evidence that higher proliferative activity is one of many features associated with pleomorphism, and atypia with grade III ependymoma [1][2][3][4]. However, neither grade nor Ki67-li predicted outcome, highlighting that the prognostic significance of grade in paediatric ependymoma remains controversial [14][15][16].…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Expression of glial acidic fibrillary protein delta and E-cadherin in ependymomas; clinic-pathological and immunohistochemistry correlation

Tena-Suck¹,

Castillejos-López²,

Díaz-Alba³

et al. 2015

J Histol Histopathol

View full text Add to dashboard Cite

Background: Ependymoma is a tumor that formed from the ependyma. Usually, in paediatric cases the location is intracranial, while in adults it is spinal. Methods: We study the prognostic implications of the current grading system, of histological and immunohistochemical features of GFAP, GFAP-δ, EMA, neurofilament and E-cadherin expression and Ki-67 in ependymomas. Results: 60 cases were included in this study of which 32 were female and 28 were male, aging ranged from 18 to 65 years old (mean age of 34.18±11.35 yr). 17 were supratentorial, 25 infratentorial and 18 cases were spinal location. Histologically 15 were grade 1, 36 were grade II and 9 grade III. 23 cases recurrence (4, 13 and 6 stage III respectively), with mean age 34.52±12.23 years vs 33.97±97.94 that not recurrence. The expression of GFAP-δ was negative in 38 cases and positive in 21(p=0.359). GFAP-δ expression was correlated with anaplastic type (grade III). Tumor grade and tumor size, brain invasion, atypia, and mitosis features and also were correlated with higher expression of neurofilament, higher ki-67-Li, as well as loss of immnunoexpression of E-Cadherina and EMA. Conclusions: PGAF, S-100, and GFAP-δ expression in ependymomas varied and depends of the histologic grade likewise the value of proliferation index. The expression of GFAP-δ was in directly relationship with presence of neurofilament and loss of E-Cadherins and EMA expression. Studies have suggested that human ependimomas arise from regionally distinct populations of radial glial cells.

show abstract

Section: Discussionsupporting

confidence: 91%

“…Ependymoma is a brain tumour that may be located in the supratentorial, infratentorial or posterior fossa as well as spinal cord [1], affects the walls of the ventricles [1][2][3]. Ependymoma is usually considered non-infiltrative tumor [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Expression of glial acidic fibrillary protein delta and E-cadherin in ependymomas; clinic-pathological and immunohistochemistry correlation

Tena-Suck¹,

Castillejos-López²,

Díaz-Alba³

et al. 2015

J Histol Histopathol

View full text Add to dashboard Cite

show abstract

“…This tumor was listed as a new type between 1993 and 2007, and was classified as WHO grade III in 2007 (2). Ependymoma arises from differentiated ependymal cells lining the ventricles (1,3), and the proportion of ependymomas among intracranial glial tumors is 3-9% (4-7). The majority of these tumors occur in the ventricle, and while intraparenchymal tumors are rare, intraparenchymal anaplastic ependymomas are even less commonly observed (8).…”

Section: Introductionmentioning

confidence: 99%

“…A positive Ki-67 labeling index is more common in anaplastic ependymoma than in low-grade ependymoma (15). Shuangshoti et al (3) reported that an increased Ki-67 labeling index was strongly correlated with increased mitotic activity and histological malignancy. Ritter et al (16) found an increased Ki-67 labeling index was linked to a poor prognosis.…”

mentioning

confidence: 99%

Magnetic resonance imaging findings of extraventricular anaplastic ependymoma: A report of 11 cases

et al. 2016

View full text Add to dashboard Cite

Abstract. Anaplastic ependymomas are rare malignant tumors of the central nervous system. Few studies are available regarding their neuroradiological characteristics. The present study aimed to retrospectively review a series of patients with extraventricular anaplastic ependymoma and to analyze the magnetic resonance imaging (MRI) characteristics to distinguish anaplastic ependymoma from other intracranial tumors. The clinical and pathological images of 11 patients who presented with histologically proven anaplastic ependymoma at Nanfang Hospital (Southern Medical University, Guangzhou, Guangdong, China) between September 2004 and March 2015 were retrospectively reviewed. MRI scans were obtained in all 11 cases. Computed tomography scans were obtained in only 3 cases. In total, 8 tumors were located at the supratentorial parenchyma, and 3 tumors were derived from the cerebellar hemisphere. Images displayed quasi-circular (4/11), irregularly-lobulated (7/11) variable-intensity masses. The masses presented with cysts or necrosis (8/11), hemorrhage (7/11), marked (9/11) or mild (2/11) enhancement, and moderate (4/11), mild (3/11) or absent (4/11) peritumoral edema. The tumors were also frequently closely associated with the lateral ventricle (6/11). Tumors appeared isointense to hypointense on T1-weighted imaging (T1WI) and heterogeneously hyperintense or hypointense on T2WI, demonstrating wreath-like and ring-like characteristics, with intratumoral nodules (3/11) or marked flake-like inhomogeneous (6/11) enhancement on post-contrast MRI. Only 2 solid lesions showed mild enhancement (2/11). Although the MRI features of the extraventricular anaplastic ependymomas varied and were non-specific, these characteristic MRI findings, combined with the locations of the lesions, the age of onset and the short disease course, could be useful in differentiating anaplastic ependymomas from other intracranial neoplasms in the future.

show abstract

“…8) Ependymomas typically arise infratentorially, often filling the fourth ventricle, but can arise in any ventricle as well in the cerebral parenchyma, or even confined within the cerebral cortices. 12,17) Supratentorial ependymoma is an uncommon but distinct entity, 2,5,6,9,[12][13][14]17,18,20) which typically reaches a large size and appears as intraparenchymal and extraventricular, or periventricular cystic masses on initial presentation. 2,6) Supratentorial ependymoma frequently has intratumoral calcification, especially if low grade.…”

Section: Introductionmentioning

confidence: 99%

Huge Supratentorial Extraventricular Anaplastic Ependymoma Presenting With Massive Calcification -Case Report-

Hamano

Tsutsumi

Nonaka

et al. 2010

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 15-year-old boy presented with an anaplastic supratentorial ependymoma causing massive intratumoral calcification, without contributory medical and family history, and manifesting as persistent headache for 2 months. Physical examination found no neurological deficit except for visual defect in the right lower quadrant, with intact visual acuity. Blood examination showed no abnormalities. Cranial computed tomography revealed a huge calcified mass in the left parietooccipital lobe, with extensive perilesional brain edema. Cranial radiography showed diffuse and symmetrical thinning of the calvarial bone. Magnetic resonance imaging confirmed the tumor as an assembly of medullated masses with extraventricular location, 7 × 6.5 × 6.5 cm in diameter, and appearing as heterogeneous intensity on both T 1 -and T 2 -weighted images with inhomogeneous enhancement except for the central cores. The patient underwent tumor resection. Intraoperative findings revealed that the cortical veins overlying the tumor were reddish and moderately engorged. The hypervascular tumor, entirely extraventricular in location, was totally resected without neurological deterioration. Histological examination revealed that the tumor was highly cellular with hyperchromatic nuclei and cell atypia. Necrosis, mitotic figures, and perivascular pseudorosette formations were frequently seen. Immunohistochemical study showed positive staining for glial fibrillary acidic protein, S-100 protein, vimentin, and epithelial membrane antigen, but negative for synaptophysin. The MIB-1 labeling index was 26.5%. The findings were compatible with anaplastic ependymoma (World Health Organization classification grade 3). Ependymoma should be included in the differential diagnosis of a supratentorially located, extraventricular mass with massive intratumoral calcification.

show abstract

Supratentorial extraventricular ependymal neoplasms

Cited by 79 publications

References 64 publications

Expression of glial acidic fibrillary protein delta and E-cadherin in ependymomas; clinic-pathological and immunohistochemistry correlation

Expression of glial acidic fibrillary protein delta and E-cadherin in ependymomas; clinic-pathological and immunohistochemistry correlation

Magnetic resonance imaging findings of extraventricular anaplastic ependymoma: A report of 11 cases

Huge Supratentorial Extraventricular Anaplastic Ependymoma Presenting With Massive Calcification -Case Report-

Contact Info

Product

Resources

About