Supratentorial hemispheric ependymomas: an analysis of 109 adults for survival and prognostic factors

Hollon, Todd; Nguyen, Vincent; Smith, Brandon W.; Lewis, Spencer; Junck, Larry; Orringer, Daniel A.

doi:10.3171/2015.7.jns151187

Cited by 25 publications

(12 citation statements)

References 56 publications

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“…In the majority of studies, extent of resection has emerged as one of the most significant predictors of outcome. [28][29][30][31][32][33] In a retrospective series of WHO grade II ependymomas in adults, 31 the 5-and 10-year OS rates were 86.1% and 81%, respectively. Preoperative KPS, extent of resection, and tumor location were independent prognostic factors for OS.…”

Section: Treatment Of Newly Diagnosed Intracranial Ependymal Tumors Imentioning

confidence: 99%

EANO guidelines for the diagnosis and treatment of ependymal tumors

et al. 2017

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Ependymal tumors are rare CNS tumors and may occur at any age, but their proportion among primary brain tumors is highest in children and young adults. Thus, the level of evidence of diagnostic and therapeutic interventions is higher in the pediatric compared with the adult patient population.The diagnosis and disease staging is performed by craniospinal MRI. Tumor classification is achieved by histological and molecular diagnostic assessment of tissue specimens according to the World Health Organization (WHO) classification 2016. Surgery is the crucial initial treatment in both children and adults. In pediatric patients with intracranial ependymomas of WHO grades II or III, surgery is followed by local radiotherapy regardless of residual tumor volume. In adults, radiotherapy is employed in patients with anaplastic ependymoma WHO grade III, and in case of incomplete resection of WHO grade II ependymoma. Chemotherapy alone is reserved for young children <12 months and for adults with recurrent disease when further surgery and irradiation are no longer feasible. A gross total resection is the mainstay of treatment in spinal ependymomas, and radiotherapy is reserved for incompletely resected tumors. Nine subgroups of ependymal tumors across different anatomical compartments (supratentorial, posterior fossa, spinal) and patient ages have been identified with distinct genetic and epigenetic alterations, and with distinct outcomes. These findings may lead to more precise diagnostic and prognostic assessments, molecular subgroup-adapted therapies, and eventually new recommendations pending validation in prospective studies.

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Section: Treatment Of Newly Diagnosed Intracranial Ependymal Tumors Imentioning

confidence: 99%

EANO guidelines for the diagnosis and treatment of ependymal tumors

et al. 2017

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“…Surgery is the first step of standard treatment. In the majority of studies, the extent of resection has emerged as one of the most significant predictors of outcome [ 2 , 47 – 52 , 53 •]. In a retrospective series of WHO grade 2 ependymomas in adults [ 51 ], gross total resection (GTR) and infratentorial location were associated with a longer OS.…”

Section: Management Of Newly Diagnosed Intracranial Ependymomas In Ad...mentioning

confidence: 99%

Ependymoma: Evaluation and Management Updates

et al. 2022

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Purpose of Review To review state of art and relevant advances in the molecular genetics and management of ependymomas of children and adults. Recent Findings Ependymomas may occur either in the brain or in the spinal cord. Compared with intracranial ependymomas, spinal ependymomas are less frequent and exhibit a better prognosis. The new WHO classification of CNS tumors of 2021 has subdivided ependymomas into different histomolecular subgroups with different outcome. The majority of studies have shown a major impact of extent of resection; thus, a complete resection must be performed, whenever possible, at first surgery or at reoperation. Conformal radiotherapy is recommended for grade 3 or incompletely resected grade II tumors. Proton therapy is increasingly employed especially in children to reduce the risk of neurocognitive and endocrine sequelae. Craniospinal irradiation is reserved for metastatic disease. Chemotherapy is not useful as primary treatment and is commonly employed as salvage treatment for patients failing surgery and radiotherapy. Summary Standard treatments are still the mainstay of treatment: the discovery of new druggable pathways will hopefully increase the therapeutic armamentarium in the near future.

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“…Анализ литературы показывает, что общая выживаемость при различных стратегиях лечения (например, системное лечение, повторное облучение или хирургическое повторное вмешательство с последующей адъювантной терапией) существенно не различалась. Как и ожидалось, более пожилой возраст, распространение опухоли на несколько долей и использование КС были значительно связаны с более короткой выживаемостью [71][72][73][74].…”

Section: мультимодальный подход к лечению рецидива гвсзunclassified

High-grade gliomas: a literature review. Part 2. Radiosurgical treatment

Gretskikh

Токарев

2022

Nejrohirurgiâ (Mosk.)

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Malignant brain tumors remain one of the most complex problem in modern oncology, being among the most dangerous types of cancer not only because of their poor prognosis, but also due to the immediate consequences for quality of life and cognitive functions. It is expected that the number of such patients will increase as the life expectancy of the population increases.The mortality rate of patients with malignant gliomas remains the highest among all cancer patients. The median survival rate in this population does not exceed 24.5 months. Despite serious progress in the study of the molecular biology of this type of tumor, the question of effective application of this knowledge in the treatment process remains open.The review highlights the most advanced diagnostic methods and analyzes the effectiveness of a multidisciplinary therapeutic strategy. Special attention is given to the search for new approaches to radiosurgical treatment of high-grade gliomas in order to increase the duration and improve the quality of life of patients. The literature review is divided into 2 parts. Part 1 covers the epidemiology, clinic, and diagnosis of high-grade gliomas, as well as a combined approach to the treatment of the disease. In the 2nd part, the issues of stereotactic radiosurgery of high-grade gliomas, the features of the practical application of the “gamma knife” device in this pathology are highlighted; the effectiveness of the multimodal approach to the treatment of malignant gliomas is analyzed.

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Supratentorial hemispheric ependymomas: an analysis of 109 adults for survival and prognostic factors

Cited by 25 publications

References 56 publications

EANO guidelines for the diagnosis and treatment of ependymal tumors

EANO guidelines for the diagnosis and treatment of ependymal tumors

Ependymoma: Evaluation and Management Updates

High-grade gliomas: a literature review. Part 2. Radiosurgical treatment

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