Supratentorial metastasis of medulloblastoma in adults

Kumar, Sushil; Handa, Amit; Jha, Deepak Kumar; Choudhary, Ajay

doi:10.4103/1793-5482.149993

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…The similarities in morphology, gene expression, and a conserved SHH signature in metastatic tumor in murine and PDX models, all reminiscent of SHH MB metastasis in patients, indicate that ATOH1-driven tumorigenesis provides an opportunity to study metastasis of naïve SHH MB in humans (4, 7, 38–42). However, the role of ATOH1 in recurrence (local or distant relapse) remains unclear.…”

Section: Discussionmentioning

confidence: 99%

ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas

et al. 2017

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Medulloblastoma (MB) arising from the cerebellum is the most common pediatric brain malignancy, with leptomeningeal metastases often present at diagnosis and recurrence associated with poor clinical outcome. In this study, we employed mouse MB models to explore the relationship of tumor pathophysiology and dysregulated expression of the NOTCH pathway transcription factor ATOH1, which is present in aggressive MB subtypes driven by aberrant Sonic Hedgehog/Patched (SHH/PTCH) signaling. In experiments with conditional ATOH1 mouse mutants crossed to Ptch1+/− mice which develop SHH-driven MB, animals with Atoh1 transgene expression developed highly penetrant MB at a young age with extensive leptomeningeal disease and metastasis to the spinal cord and brain, resembling xenografts of human SHH MB. Metastatic tumors retained abnormal SHH signaling like tumor xenografts. Conversely, ATOH1 expression was detected consistently in recurrent and metastatic SHH MB. ChIP-seq and gene expression profiling identified candidate ATOH1 targets in tumor cells involved in development and tumorigenesis. Among these targets specific to metastatic tumors, there was an enrichment in those implicated in extracellular matrix remodeling activity, cytoskeletal network and interaction with microenvironment, indicating a shift in transcriptomic and epigenomic landscapes during metastasis. Treatment with bone morphogenetic protein (BMP) or SHH pathway inhibitors decreased tumor cell proliferation and suppressed metastatic tumor growth, respectively. Our work reveals a dynamic ATOH1-driven molecular cascade underlying MB metastasis that offers possible therapeutic opportunities.

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Section: Discussionmentioning

confidence: 99%

ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas

et al. 2017

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“…14 Several studies have documented the spread of MB locally to different brain regions as the ventricular system, the occipital pole, and subarachnoid space. 15 16 17 In this case, we observed intraventricular metastatic nodules and CSF seeding affecting multiple spine levels and the cauda equina. Moreover, after treatment for 1 year, the patient developed several lung lesions that are mostly metastatic.…”

Section: Discussionmentioning

confidence: 69%

An Adult Case of Medulloblastoma with Multiple Lung Metastatic Lesions—Case Report and Literature Review

Azab

2024

Asian J Neurosurg

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Medulloblastoma (MB) cerebelli is a common brain tumor of the childhood. MB commonly spreads through cerebrospinal fluid; however, there are several reported cases of extracranial spread. The most common sites of extracranial metastasis are bones and bone marrow followed by peritoneum, liver, and lungs. Here, we report a case of pulmonary metastatic lesions of adult cerebellar MB that were discovered 1 year after the primary surgical treatment. We also tried to highlight similar reported cases in the literature.

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“…Kumar et al reported two cases, aged 31 and 20 years, with supratentorial metastases occurring 3½ years and 11 months after the complete removal of posterior fossa medulloblastoma. Both patients underwent craniospinal irradiation; notably, the first case also developed spinal metastasis [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Rare incidence of parietal lobe metastasis in an adult with desmoplastic/nodular medulloblastoma: A case report and review of the literature

Zaresharifi,

Abbaspour,

Yousefzade-Chabok

et al. 2024

International Journal of Surgery Case Reports

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Supratentorial metastasis of medulloblastoma in adults

Cited by 8 publications

References 13 publications

ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas

ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas

An Adult Case of Medulloblastoma with Multiple Lung Metastatic Lesions—Case Report and Literature Review

Rare incidence of parietal lobe metastasis in an adult with desmoplastic/nodular medulloblastoma: A case report and review of the literature

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