Suprathel^®‐assisted surgical treatment of the hand in a dystrophic epidermolysis bullosa patient

Abstract

Epidermolysis bullosa (EB) is a progressive familial disorder composed of dermal mucosal blisters, flexion contractures and pseudosyndactylies. Flexion contractures and pseudosyndactyly can be treated with surgery but usually require skin grafting. Because of poor wound healing, skin graft harvesting is a challenge in these patients. In order to prevent donor-site morbidities due to skin graft harvesting some alloplastic materials were introduced. In this study, we focused on Suprathel(®) as a new allograft material for covering the skin defects of a patient with dystrophic EB.

Release of pseudosyndactyly in recessive dystrophic epidermolysis bullosa using a dermal regeneration template glove: the Foggia experience

“…Healing by secondary intention is described [12], but larger wounds require coverage to avoid infection, delayed healing with fibrosis and recurrence of contractures. In these cases, the use of skin graft (split-thickness or full-thickness), cultured keratinocytes, and cellular allograft dermal matrix (such as Apligraf ) or acellular biosynthetic material (such as Biobrane or AlloDerm-GBR) has been described in the literature [7,[16][17][18][19][20][21][22][23][24][25][26].…”

Release of pseudosyndactyly in recessive dystrophic epidermolysis bullosa using a dermal regeneration template glove – the Foggia experience.

“…In these cases, the use of skin graft (splitthickness or full-thickness), cultured keratinocytes, and cellular allograft dermal matrix (such as Apligraf) or acellular biosynthetic material (such as Biobrane or AlloDerm-GBR) has been described in the literature. 7,[16][17][18][19][20][21][22][23][24][25][26] Split-thickness skin grafts (STSG) provide coverage of wide areas, however, availability of healthy skin for autologous grafting and di cult healing at the donor site can be major problems in EB patients. Moreover, split-thickness skin graft usually provides unstable coverage with high risk of early recurrences.…”

New treatment protocol for pseudosyndactyly in epidermolysis bullosa hand using a dermal regeneration template glove.

“…In these cases, in literature was described the use of skin graft (split-thickness or full-thickness), cultured keratinocytes, and cellular allograft dermal matrix (such as Apligraf) or acellular biosynthetic material (such as Biobrane or AlloDerm-GBR). 1,2,7,[16][17][18][19][20][21][22][23][24][25][26] Split-thickness skin grafts (STSG) provide coverage of wide areas, however, availability of healthy skin for autologous grafting and di culty healing at the donor site can be major problems in EB patients.…”