Supraventricular tachycardia after respiratory syncytial virus infection in a newborn

Aydoğan, Seda; Fettah, Nurdan Dinlen; Tugcu, Ali Ulas; Koyuncu, Ece; Yoldaş, Tamer; Zencıroğlu, Ayşegül

doi:10.1080/08998280.2022.2086788

Cited by 1 publication

(1 citation statement)

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“…Most variables were distributed similarly between the two treatment groups (P > 0.05), except for antibiotic treatment received, birth weight (median weight at birth: 3.4 kg for shortterm vs. 3.0 kg for long-term; P=0.02), presence of pets in the household (no pets at home: 36.4 % for short-term vs. 68.0 % for long-term; P=0.03), and heart-rate at triage (mean heartrate: 153 bpm for short-term vs. 175 bpm for long term group; P=0.007) (Table S1). While the ANTIBIO study was not designed to examine the associations between antibiotic use and these participant characteristics, they likely reflect known associations between increased infection risk or severity and the need for prolonged antibiotic administration [30][31][32][33][34] . Nevertheless, as potential confounders of the effects of antibiotics on microbiome composition, these variables were included in our subsequent analyses.…”

Section: The Antibio Studymentioning

confidence: 99%

Antibiotic-inducedMalasseziaspp. expansion in infants promotes early-life immune dysregulation and airway inflammation in mice

Bernardes,

Gutierrez,

Nguyen

et al. 2024

Preprint

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Antibiotics have deleterious consequences for the gut microbiome and can increase the risk of childhood asthma. While the effects of antibiotics on the bacterial microbiome and asthma risk are well characterized, their impact on the fungal microbiome (mycobiome) remains vastly unexplored. We investigated the effect of antibiotic use on the gut mycobiome in an observational, prospective clinical study of young infants. Antibiotic treatment resulted in increased fungal abundance and expansion of the yeast Malassezia spp. Based on these findings, germ-free mouse pups were colonized with a defined consortium of mouse-derived bacteria (Oligo-MM12) with or without Malassezia restricta. Colonization with this yeast increased myeloid and lymphoid intestinal immune responses deemed critical in atopy development, and elevated airway inflammation in house-dust mite (HDM)-challenged mice. Further evaluation in eosinophil-deficient mice revealed that the observed immune response is partially dependent on this cell type. This translational work demonstrates that fungal overgrowth and expansion of Malassezia spp. are previously overlooked collateral effects of infant antibiotic use, which may offer a potential strategy to prevent or mitigate pediatric asthma and related conditions.

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Section: The Antibio Studymentioning

confidence: 99%