Supraventricular Tachycardia in Children

Carbamazepine is an anticonvulsant that is commonly used in neurological and psychiatric patients to treat epileptic seizures, neuropathic pain, or bipolar disorder. Carbamazepine side effects, as well as side effects of many antiepileptic drugs, include cardiotoxic effects such as atrioventricular block, bradycardia, and cardiac rhythm disorders. However, carbamazepine has also been reported to have antiarrhythmic, normotimic, and membrane-stabilizing effects. This results in its administration to treat arrhythmias in children. Based on literature, carbamazepine administration as anti-arrhythmic drug is known in cases where the basic therapy was ineffective. The medication is not registered anywhere in the world for this purpose. Thus, it can be administered only off-label. The aim of our literature review is to analyze and summarize the existing data on carbamazepine effects on cardiovascular system, to determine its safety as anti-arrhythmic drug, and to describe various factors fostering its side effects.

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Effects of Carbamazepine on Cardiovascular System: Literature Review

Gordeev

Kulbachinskaya

Bereznitskaya

2023

Pediatr. farmakol.

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Atrial flutter in newborns

Kurmaeva

Volgina

Solovyeva

et al. 2021

Ross. vestn. perinatol. pediatr.

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Objective. To describe a case of atrial flutter in a newborn.Results. The child in the maternity hospital was found to have a heart rhythm disorder of the type: atrial flutter, constant form. Examination revealed an atrial septal defect and an increase in the level of natriuretic peptide. Subsequently, the child was diagnosed with atrial flutter, constant form. NK 0-1. Open oval window. Treatment with drugs from the group of antiarrhythmics, antioxidants and cardiac glycosides made it possible to avoid pronounced hemodynamic disorders.Conclusion. The presented case demonstrates that timely diagnosis and medical correction prevent possible complications.

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Prognostic factors for the effectiveness of catheter ablation of focal atrial tachycardia in school-age children: data from a single-center registry study

Kovalchuk,

Tatarsky,

Alekseeva

et al. 2024

Vestnik aritmologii

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Aim. To identify factors associated with the effectiveness of radiofrequency catheter ablation (RFA) of focal atrial tachycardia (AT) in school-aged patients in the long-term period.Methods. The study group consisted of 57 children aged 11 to 17 years 11 months (Me 15.83, IQR 14.63-17.0), who underwent catheter ablation, including repeated, for focal AT in the Almazov National Medical Research Centre from December 2009 until April 2023. We analyzed clinical and demographic data, laboratory data, parameters of tachyarrhythmia, electrophysiological study and RFA. Structural heart diseases were present in 13 children, and idiopathic arrhythmia was present in 44 patients. The criterion for intraoperative effectiveness were the absence of arrhythmia at the end of the waiting period in the X-ray operating room, delayed - within 12 months after the procedure.Results. Intraoperative effectiveness of RFA was achieved in 51 patients (89.5%), long-term - in 32 patients (56.1%). Based on the data obtained, a prognostic model of the delayed effectiveness of RFA of focal AT in school-age children was developed (p<0.001). Predictors included in the model: percentage of arrhythmia during the day (odds ratio (OR): 0.981; 95% confidence interval (CI) 0.962-0.999; p=0.043), presyncope (OR: 0.177; 95% CI 0.035-0.903; p=0.037), number of ectopic foci (OR: 0.289; 95% CI 0.128-0.649; p=0.003), right atrium localization (OR: 0.097; 95% 0.013-0.699; p=0.021). The area under the ROC curve corresponding to the association of the absence of arrhythmia after ablation and the values of the logistic regression function was 0.843±0.54 with 95% CI: 0.738-0.938. The sensitivity was 81.3%, specificity - 76.0%. No significant association with effectiveness of RFA was found between the method of arrhythmia induction and the use of drug sedation.Conclusion. It was established that factors such as percentage of arrhythmia during the day, the presence of presyncope, the number of ectopic foci and the presence of an ectopic foci in the right atrium had an inverse relationship with the effective outcome of RFA.

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Supraventricular Tachycardia in Children

Cited by 4 publications

References 15 publications

Effects of Carbamazepine on Cardiovascular System: Literature Review

Effects of Carbamazepine on Cardiovascular System: Literature Review

Atrial flutter in newborns

Prognostic factors for the effectiveness of catheter ablation of focal atrial tachycardia in school-age children: data from a single-center registry study

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