Sur le rôle possible des deux acides nucléiques dans la cellule vivante

Boivin, A.; Vendrely, R

doi:10.1007/bf02155119

Cited by 33 publications

(13 citation statements)

References 7 publications

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“…Shortly afterwards, Boivin and Vendrely (1947) carried the scheme of Brachet to its logical conclusion and proposed that ''DNA makes RNA makes Proteins.'' This 1947 version of the central dogma of molecular biology was largely ignored, but the idea was born and the evidence started accumulating.…”

Section: The Apparatus Of Protein Synthesismentioning

confidence: 99%

Evolution of the Genetic Code: The Ribosome-Oriented Model

Barbieri

2015

Biol Theory

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There are currently three major theories on the origin and evolution of the genetic code: the stereochemical theory, the coevolution theory, and the error-minimization theory. The first two assume that the genetic code originated respectively from chemical affinities and from metabolic relationships between codons and amino acids. The error-minimization theory maintains that in primitive systems the apparatus of protein synthesis was extremely prone to errors, and postulates that the genetic code evolved in order to minimize the deleterious effects of the translation errors. This article describes a fourth theory which starts from the hypothesis that the ancestral genetic code was ambiguous and proposes that its evolution took place with a mechanism that systematically reduced its ambiguity and eventually removed it altogether. This proposal is distinct from the stereochemical and the coevolution theories because they do not contemplate any ambiguity in the genetic code, and it is distinct from the error-minimization theory because ambiguity-reduction is fundamentally different from error-minimization. The concept of ambiguity-reduction has been repeatedly mentioned in the scientific literature, but so far it has remained only an abstract possibility because no model has been proposed for its mechanism. Such a model is described in the present article and may be the first step in a new approach to the study of the evolution of the genetic code.

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Section: The Apparatus Of Protein Synthesismentioning

confidence: 99%

Evolution of the Genetic Code: The Ribosome-Oriented Model

Barbieri

2015

Biol Theory

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“…The principle that DNA makes RNA makes protein was first put into print in 1947 (at least 10 years before Crick) by two bacteriologists, Boivin and Vendrely [8]; or rather, by the anonymous editor who compressed their paper in Experientia into an English-language summary, less ambiguous than the text.…”

Section: Introductionmentioning

confidence: 99%

Revisiting Crick?s Dogma and the Impossibility of Reverse Translation

Biro¹

2014

J Theor Comput Sci

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“…[12] In summarizing a 1947 Experientia paper by Boivin and Vendrely, an anonymous editor concluded: ªThrough catalytic actions the macromolecular desoxyribonucleic acids govern the building of macromolecular ribonucleic acids, and, in turn, these control the production of cytoplasmic enzymesº. [13] This statement, although formulating the essence of biological information flow, did not specify the exact components and mechanisms involved. After the 1953 elucidation of the double helical structure of DNA by Watson and Crick, [14] attention turned to the roles RNA plays in gene expression.…”

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confidence: 98%

RNA and the Small Molecule World

Tor

1999

Angew. Chem. Int. Ed.

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A key role in essential cellular processes is played by RNA molecules, and these are attractive targets for drug design. The functional diversity of RNA can be attributed to the sophisticated three-dimensional structures it assumes. These intricate folds create potential binding pockets for ions, low molecular weight ligands, and proteins. Recent experiments have demonstrated that small molecules such as tobramycin (1) can regulate gene expression in living cells through specific interactions with a messenger RNA (mRNA).

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Sur le rôle possible des deux acides nucléiques dans la cellule vivante

Cited by 33 publications

References 7 publications

Evolution of the Genetic Code: The Ribosome-Oriented Model

Evolution of the Genetic Code: The Ribosome-Oriented Model

Revisiting Crick?s Dogma and the Impossibility of Reverse Translation

RNA and the Small Molecule World

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