Surface acoustic wave based microfluidic devices for biological applications

Liu, Xianglian; Chen, Xuan; Yang, Ziwei; He, Xijing; Zhang, Chuanyu; Wei, Xueyong

doi:10.1039/d2sd00203e

Cited by 19 publications

(15 citation statements)

References 146 publications

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“…In 2023, Wei et al [ 68 ] classified and summarized SAW devices based on different vibration modes and boundary conditions. The team pointed out that SAW devices with guided wave layers that existed in IDT regions based on Rayleigh waves could limit acoustic energy to piezoelectric surfaces and had high sensitivity to surface modifications.…”

Section: Flexible Saw Sensorsmentioning

confidence: 99%

“… SSAW devices for the separation of other bioparticles. ( a ) Schematic of the acoustofluidic separation of E. coli from human blood samples using the taSSAW technique [ 68 ]; ( b ) the SSAW-enabled serpentine microfluidic device for high-throughput bacterial separation from human blood cells [ 68 ]; ( c ) schematic of the acoustofluidic device for salivary exosome separation [ 68 ]; and ( d ) schematic detailing the process of the isolation of exosomes from plasma samples [ 68 ]. Reference [ 68 ] has been certified as open access by the Royal Society of Chemistry.…”

Section: Figurementioning

confidence: 99%

“… LW-SAW devices for biomolecule detection. ( A ) Schematic of the sandwich immunoassay format and LW-SAW sensor array for cardiac markers detection [ 68 ]. ( a ) Top and cross-sectional views of the single-packaged Love wave SAW sensor.…”

Section: Figurementioning

confidence: 99%

“…( a ) Top and cross-sectional views of the single-packaged Love wave SAW sensor. ( b ) Top view of the Love wave SAW sensor array; and ( B ) schematic illustration of an SAW biosensor for highly specific and signal-amplified DNA detection [ 68 ]. Reference [ 68 ] has been certified as open access by the Royal Society of Chemistry.…”

Section: Figurementioning

confidence: 99%

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Recent Progress in Flexible Surface Acoustic Wave Sensing Technologies

Liang,

Yan,

Zhai

et al. 2024

Micromachines

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In this work, the major methods for implementing flexible sensing technology—flexible surface acoustic wave (SAW) sensors—are summarized; the working principles and device characteristics of the flexible SAW sensors are introduced; and the latest achievements of the flexible SAW sensors in the selection of the substrate materials, the development of the piezoelectric thin films, and the structural design of the interdigital transducers are discussed. This paper focuses on analyzing the research status of physical flexible SAW sensors such as temperature, humidity, and ultraviolet radiation, including the sensing mechanism, bending strain performance, device performance parameters, advantages and disadvantages, etc. It also looks forward to the development of future chemical flexible SAW sensors for gases, the optimization of the direction of the overall device design, and systematic research on acoustic sensing theory under strain. This will enable the manufacturing of multifunctional and diverse sensors that better meet human needs.

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Section: Flexible Saw Sensorsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Recent Progress in Flexible Surface Acoustic Wave Sensing Technologies

Liang,

Yan,

Zhai

et al. 2024

Micromachines

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“…Among these examples, microfluidics has demonstrated the ability to manipulate individual droplets and micro to nano-objects in liquids, enabled by various forces associated with magnetics, 14 optical, 15 acoustics, 16,17 electrowetting-on-dielectrics, dielectrophoresis, and hydrodynamics. Acoustic tweezers based on bulk acoustic waves (BAWs) 18 and surface acoustic waves (SAWs) 19,20 allow for on-chip micro-manipulation that is contactless, 21 non-invasive, 22 and highly biocompatible. 23 Given these unique advantages, acoustic tweezers have become a highly promising manipulation method and could play a crucial role in biomedical detection.…”

Section: Introductionmentioning

confidence: 99%

Acoustofluidics for simultaneous droplet transport and centrifugation facilitating ultrasensitive biomarker detection

Qian,

Lan,

Huang

et al. 2023

Lab Chip

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A SAW‐Based Programmable Controlled RNA Detecting Device: Rapid In Situ Cytolysis‐RNA Capture‐RNA Release‐PCR in One Mini Chamber

Yang,

Wang,

Xie

et al. 2024

Advanced Science

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Viral RNA detection is crucial in preventing and treating early infectious diseases. Traditional methods of RNA detection require a large amount of equipment and technical personnel. In this study, proposed a programmable controlled surface acoustic wave (SAW)‐based RNA detecting device has been proposed. The proposed device can perform the entire viral RNA detection process, including cell lysis by cell‐microparticle collision through SAW‐induced liquid whirling, RNA capture by SAW‐suspended magnetic beads, RNA elution through SAW‐induced high streaming force, and PCR thermal cycling through SAW‐generated heat. The device has completed all RNA detection steps in one mini chamber, requiring only 489 µl reagents for RNA extraction, much smaller than the amount used in manual RNA extraction (2065 µl). The experimental results have shown that PCR results from the device are comparable to those achieved via commercial qPCR instrumental detection. This work has demonstrated the potential of SAW‐based lab‐on‐a‐chip devices for point‐of‐care testing and provided a novel approach for rapidly detecting infectious diseases.

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Surface acoustic wave based microfluidic devices for biological applications

Abstract: Surface acoustic wave (SAW) devices have been widely used in the field of biological detection, including as actuators for sample pretreatment process and as biosensors for qualitative or quantitative detection...

Cited by 19 publications

References 146 publications

Recent Progress in Flexible Surface Acoustic Wave Sensing Technologies

Recent Progress in Flexible Surface Acoustic Wave Sensing Technologies

Acoustofluidics for simultaneous droplet transport and centrifugation facilitating ultrasensitive biomarker detection

A SAW‐Based Programmable Controlled RNA Detecting Device: Rapid In Situ Cytolysis‐RNA Capture‐RNA Release‐PCR in One Mini Chamber

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