Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

Anestopoulos, Ioannis; Kiousi, Despoina Eugenia; Klavaris, Ariel; Galanis, Αlex; Sałek, Karina; Euston, Stephen R.; Pappa, Aglaia; Panayiotidis, Mihalis Ι.

doi:10.3390/pharmaceutics12070688

Cited by 54 publications

(32 citation statements)

References 223 publications

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“…Apart from their ability to reduce surface and interfacial tension, they often have the potential to interact, both specifically and nonspecifically, with biological molecules, most commonly lipid membranes and proteins. Consequently, they exhibit a panel of bioactivities such as antioxidant, anti-microbial, anti-cancer, anti-aging, and anti-inflammatory properties [ 9 , 10 ]. The health promoting properties of biosurfactants are of great importance for cosmeceutical and food industries, as they are often desirable by the consumers and thus can facilitate the promotion of these products.…”

Section: Introductionmentioning

confidence: 99%

Toxicity Profiling of Biosurfactants Produced by Novel Marine Bacterial Strains

Voulgaridou

Mantso

Anestopoulos

et al. 2021

IJMS

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Surface active agents (SAAs), currently used in modern industry, are synthetic chemicals produced from non-renewable sources, with potential toxic impacts on humans and the environment. Thus, there is an increased interest for the identification and utilization of natural derived SAAs. As such, the marine environment is considered a promising source of biosurfactants with low toxicity, environmental compatibility, and biodegradation compared to their synthetic counterparts. MARISURF is a Horizon 2020 EU-funded project aiming to identify and functionally characterize SAAs, derived from a unique marine bacterial collection, towards commercial exploitation. Specifically, rhamnolipids produced by Marinobacter MCTG107b and Pseudomonas MCTG214(3b1) strains were previously identified and characterized while currently their toxicity profile was assessed by utilizing well-established methodologies. Our results showed a lack of cytotoxicity in in vitro models of human skin and liver as indicated by alamar blue and propidium iodide assays. Additionally, the use of the single gel electrophoresis assay, under oxidative stress conditions, revealed absence of any significant mutagenic/anti-mutagenic potential. Finally, both 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonicacid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) cell-free assays, revealed no significant anti-oxidant capacity for neither of the tested compounds. Consequently, the absence of significant cytotoxicity and/or mutagenicity justifies their commercial exploitation and potential development into industrial end-user applications as natural and environmentally friendly biosurfactants.

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Section: Introductionmentioning

confidence: 99%

Toxicity Profiling of Biosurfactants Produced by Novel Marine Bacterial Strains

Voulgaridou

Mantso

Anestopoulos

et al. 2021

IJMS

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“…These results further aggravate lung injury. The phospholipid structures of the hydrophobic parts of NIS stabilize the phospholipid structure and make it face the air space 11 . This further results in a reduced surface tension, maintaining the air-water interface and, therefore, preventing the alveoli from further injury.…”

Section: Discussionmentioning

confidence: 99%

“…Nonionic surfactants (NIS), a kind of surfactants composed of two parts, hydrophilic and hydrophobic parts, do not have electric charge on their hydrophilic parts 11 . NIS orient themselves in the layer lattice, where the hydrophobic parts are arranged towards the aqueous bulk, and the hydrophobic parts are arranged in a way that minimizes the interaction with the aqueous bulk.…”

Section: Introductionmentioning

confidence: 99%

“…NIS orient themselves in the layer lattice, where the hydrophobic parts are arranged towards the aqueous bulk, and the hydrophobic parts are arranged in a way that minimizes the interaction with the aqueous bulk. The features of biphasic coupling can minimize the surface tension 11 . In addition, NIS, such as tyloxapol, have been shown to have anti-inflammatory effects with a decreasing level of cytokines 12 .…”

Section: Introductionmentioning

confidence: 99%

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Nonionic surfactant attenuates acute lung injury by restoring epithelial integrity and alveolar fluid clearance

Hsieh¹,

Kuo²,

Wu³

et al. 2021

Int. J. Med. Sci.

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Introduction: Acute lung injury (ALI) has a great impact and a high mortality rate in intensive care units (ICUs). Excessive air may enter the lungs, causing pulmonary air embolism (AE)-induced ALI. Some invasive iatrogenic procedures cause pulmonary AE-induced ALI, with the presentation of severe inflammatory reactions, hypoxia, and pulmonary hypertension. Pulmonary surfactants are vital in the lungs to reduce the surface tension and inflammation. Nonionic surfactants (NIS) are a kind of surfactants without electric charge on their hydrophilic parts. Studies on NIS in AE-induced ALI are limited. We aimed to study the protective effects and mechanisms of NIS in AE-induced ALI. Materials and methods: Five different groups (n = 6 in each group) were created: sham, AE, AE + NIS pretreatment (0.5 mg/kg), AE + NIS pretreatment (1 mg/kg), and AE + post-AE NIS (1 mg/kg). AE-induced ALI was introduced by the infusion of air via the pulmonary artery. Aerosolized NIS were administered via tracheostomy. Results: Pulmonary AE-induced ALI showed destruction of the alveolar cell integrity with increased pulmonary microvascular permeability, pulmonary vascular resistance, pulmonary edema, and lung inflammation. The activation of nuclear factor-κB (NF-κB) increased the expression of pro-inflammatory cytokines, and sodium-potassium-chloride co-transporter isoform 1 (NKCC1). The pretreatment with NIS (1 mg/kg) prominently maintained the integrity of the epithelial lining and suppressed the expression of NF-κB, pro-inflammatory cytokines, and NKCC1, subsequently reducing AE-induced ALI. Conclusions: NIS maintained the integrity of the epithelial lining and suppressed the expression of NF-κB, pro-inflammatory cytokines, and NKCC1, thereby reducing hyperpermeability, pulmonary edema, and inflammation in ALI.

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“…Considering the high incidence and recurrence of VCC and the development of intrinsically resistant Candida species as a consequence of extensive use of antifungal azoles [ 3 , 4 ], new treatment strategies are extremely desirable. Biosurfactants (BS), surface active agents produced by living microorganisms as secondary metabolites [ 5 ], have been proven to exert anti-microbial and anti-biofilm activity against different human pathogens and can represent potential candidates for the treatment of local infections [ 6 ]. In particular, biosurfactants isolated from probiotic bacteria, including Lactobacillus , may offer the opportunity to deliver health benefits, as probiotics are part of healthy microbiota and therefore are beneficial for humans and safe for therapeutic purposes [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus crispatus BC1 Biosurfactant Delivered by Hyalurosomes: An Advanced Strategy to Counteract Candida Biofilm

et al. 2021

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The emergence of resistance to antifungal drugs has made the treatment of vulvovaginal candidiasis (VVC) very challenging. Among natural substances, biosurfactants (BS) produced by Lactobacillus have gained increasing interest in counteracting Candida infections for their proven anti-adhesive properties and safety profile. In the present study, liposomes (LP-BS) or liposomes coated with hyaluronic acid (HY-LP-BS) were prepared in the presence of the BS isolated from the vaginal strain Lactobacillus crispatus BC1 and characterized in terms of size, ζ potential, stability and mucoadhesion. The anti-biofilm activity of free BS, LP-BS and HY-LP-BS was investigated against different Candida albicans and non-albicans strains (C. glabrata, C. lusitaniae, C. tropicalis, C. krusei and C. parapsilosis), clinically isolated from patients affected by VVC. The inhibition of biofilm formation and the dispersal of pre-formed biofilm were evaluated. The obtained phospholipid vesicles showed suitable size for vaginal application and good stability over the storage period. HY-LP-BS exhibited good mucoadhesive properties and the best anti-biofilm profile, both in preventing or limiting the surface colonization by a broad spectrum of Candida species. In conclusion, the formulation of a novel antifungal agent derived from the vaginal microbiota into mucoadhesive nanocarriers appears to be a promising biotherapeutic strategy to counteract vulvovaginal candidiasis.

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Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

Cited by 54 publications

References 223 publications

Toxicity Profiling of Biosurfactants Produced by Novel Marine Bacterial Strains

Toxicity Profiling of Biosurfactants Produced by Novel Marine Bacterial Strains

Nonionic surfactant attenuates acute lung injury by restoring epithelial integrity and alveolar fluid clearance

Lactobacillus crispatus BC1 Biosurfactant Delivered by Hyalurosomes: An Advanced Strategy to Counteract Candida Biofilm

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