Surface-Active Biomaterials

Hench, Larry L.; Wilson, June

doi:10.1126/science.6093253

Cited by 901 publications

(518 citation statements)

References 22 publications

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“…17 Sol-gel BAG, prepared in our laboratory, is a three-dimensional cross-linked matrix of hydrolyzed alkoxides of SiO 2 , CaO, and P 2 O 5 that releases ions such as calcium, phosphate, and fluoride. 18,19 This release of ions into surrounding solution is a process that has the potential to prevent demineralization of enamel and thereby to prevent WSL formation around orthodontic brackets.…”

Section: Introductionmentioning

confidence: 99%

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

Manfred

Covell

Crowe

et al. 2012

The Angle Orthodontist

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Objective: To compare changes in enamel microhardness adjacent to orthodontic brackets after using bonding agents containing various compositions of bioactive glass compared to a traditional resin adhesive following a simulated caries challenge. Materials and Methods: Extracted human third molars (n 5 10 per group) had orthodontic brackets bonded using one of four novel bioactive glass (BAG)-containing orthodontic bonding agents (BAG-Bonds) or commercially available Transbond-XT. The four new adhesives contained BAG in varying percentages incorporated into a traditional resin monomer mixture. Teeth were cycled through low-pH demineralizing and physiologic-pH remineralizing solutions once each day over 14 days. Microhardness was measured on longitudinal sections of the teeth 100, 200, and 300 mm from the bracket edge and beneath the brackets, at depths of 25 to 200 mm from the enamel surface. Normalized hardness values were compared using three-way analysis of variance. Results: Significantly less reduction in enamel microhardness was found with the experimental adhesives at depths of 25 and 50 mm at all distances from the bracket edge. In all groups, there were no significant changes in enamel microhardness past 125-mm depth. Results varied with the different BAG-Bonds, with 81BAG-Bond showing the smallest decrease in enamel microhardness. Conclusions: The BAG-Bonds tested in this study showed a reduction in the amount of superficial enamel softening surrounding orthodontic brackets compared to a traditional bonding agent. The results indicate that clinically, BAG-Bonds may aid in maintaining enamel surface hardness, therefore helping prevent white spot lesions adjacent to orthodontic brackets. (Angle Orthod. 2013;83:97-103.)

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Section: Introductionmentioning

confidence: 99%

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

Manfred

Covell

Crowe

et al. 2012

The Angle Orthodontist

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“…Como se puede observar, existe una capa de sílice intermedia entre la capa de HA y la muestra, tal como sucede en la mayoría de los vidrios y vitrocerámicos bioactivos (1,2,8).…”

Section: Resultados Y Discusiónunclassified

“…En las últimas dos décadas ha habido un interés generalizado por los materiales cerámicos, vidrios y vitrocerámi-cos bioactivos, debido principalmente a su capacidad para desarrollar una fuerte unión con el tejido óseo después de su implantación (1)(2)(3)(4). Varios autores (5-7) han descrito el mecanismo de unión como una secuencia de reacciones entre el material y el medio fisiológico.…”

Section: Introduccionunclassified

“…Varios autores (5-7) han descrito el mecanismo de unión como una secuencia de reacciones entre el material y el medio fisiológico. En la mayoría de los casos, se observó la formación de una capa intermedia, rica en sílice, seguida por otra capa exterior de fosfato cálcico (1)(2)(3)(4)(5)(6)(7). Estudios previos in vitro e in vivo han puesto de manifiesto que la wollastonita (CaSiO 3 ), material cerámico policritalino bioactivo, forma una capa de hidroxiapatito (HA) en su superficie al entrar en contacto con suero fisiológico artificial (SFA), saliva humana parotidea o al ser implantada, uniéndose a través de dicha capa directamente al tejido óseo (3,4,(8)(9)(10)(11)(12).…”

Section: Introduccionunclassified

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Efecto de la microestructura sobre la bioactividad de dos materiales vitrocerámicos del sistema CaSiO<sub>3</sub> â ZrO<sub>2</sub>

Aza¹,

Luklinska²

2003

Bol. Soc. Esp. Ceram. Vidr.

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Se estudia la influencia de la microestructura sobre la bioactividad de dos materiales vitrocerámicos con la misma composición química (87% en peso de CaSiO 3 y 13% en peso de ZrO 2 ). Por tratamiento térmico del vidrio se obtuvo un material vitrocerámico (WZ1), formado por wollastonita-2M y circona tetragonal como fases cristalinas. Dicho material vitrocerámico no presentó bioactividad en suero fisiológico artificial (SFA). Mediante procesado cerámico del polvo de vidrio, se obtuvo un material vitrocerámico (WZ2) con las mismas fases cristalinas pero con diferente microestructura, que resultó ser bioactivo. Los estudios in vitro en SFA del vitrocerámico WZ2, demostraron la formación de una capa de hidroxiapatito (HA) en su superficie. El producto de la reacción fue examinado por microscopia electrónica de barrido y transmisión (MEB y MET), ambas con microanálisis por energías dispersivas de rayos-X (EDS). Las medidas de pH, realizadas directamente en la interfase del SFA con los respectivos materiales vitrocerámicos, fueron determinantes para entender sus diferentes comportamientos. Palabras clave: Bioactividad, Vitrocerámicos, Microestructura, Wollastonita, Microscopia Electrónica de Barrido y de Transmisión Efect of the microstructure on the bioactivity of two glass-ceramics in the system CaSiO 3 -ZrO 2The work examines the influence of the microstructure on the in vitro bioactivity of two glass-ceramics with the same chemical composition. Two routes were used to obtain two glass-ceramics composed of 87 wt% CaSiO 3 -13 wt% ZrO 2 . Heat treatment of a monolith glass produces a glass-ceramic (WZ1) containing wollastonite-2M and tetragonal zirconia as crystalline phases. The WZ1 did not display bioactivity in vitro. Ceramising the glass, via powder technology route, formed a bioactive glass-ceramic (WZ2), with the same crystalline phases but different microstructure. The in vitro studies carried out on WZ2 showed the formation of an apatite-like layer on its surface during exposure to the simulated body fluid (SBF). The interfacial reaction product was examined by Scanning and Transmission Electron Microscopy, both instruments fitted with Energy-Dispersive X-ray Analysers. pH measurements, directly made at the interface of the two glass-ceramics with the simulated body fluid, were important in understanding their different behaviour during exposure to the same physiological environment.

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“…Initially, research focused on producing biomaterials that did not elicit a biological response from the host, that is, a bioinert material. By the 80s a shift developed, where new biomaterials were designed to interact with the surrounding cells and tissues (Hench and Wilson, 1984). This include biomaterials that mimic the extracellular matrix (ECM) or release soluble factors that influence activity of the surrounding cells (Hench and Thompson, 2010;Place et al, 2009).…”

Section: Interaction Of Biomaterials With Cellsmentioning

confidence: 99%

Reprogramming and Carcinogenesis—Parallels and Distinctions

Wasik

Grabarek

Pantovic

et al. 2014

International Review of Cell and Molecular Biology

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Abbreviations: CDK -Cyclin-Dependent Kinase; CSC -cancer stem cells; DSB -double strand breaks ; ECM -extracellular matrix; ES cell -embryonic stem cell; GFP -green fluorescent protein; GSK3 -glycogen synthase kinase-3; HN -Hemagglutininneuraminidase; iPS -induced pluripotent stem cells; MSFs -myocardial scar fibroblasts; RB -Retinoblastoma protein; RGD -arginine-glycine-aspartic acid; RISC -RNA-induced silencing complex; Shc -Src homology 2 domain-containing.

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Surface-Active Biomaterials

Cited by 901 publications

References 22 publications

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

Efecto de la microestructura sobre la bioactividad de dos materiales vitrocerámicos del sistema CaSiO<sub>3</sub> â ZrO<sub>2</sub>

Reprogramming and Carcinogenesis—Parallels and Distinctions

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Surface-Active Biomaterials

Cited by 901 publications

References 22 publications

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

A novel biomimetic orthodontic bonding agent helps prevent white spot lesions adjacent to brackets

Efecto de la microestructura sobre la bioactividad de dos materiales vitrocerámicos del sistema CaSiO<sub>3</sub> â ZrO<sub>2</sub>

Reprogramming and Carcinogenesis—Parallels and Distinctions

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Efecto de la microestructura sobre la bioactividad de dos materiales vitrocerámicos del sistema CaSiO<sub>3</sub> â ZrO<sub>2</sub>