Surface active ionic liquid induced conformational transition in aqueous medium of hemoglobin

Vashishat, Rajni; Chabba, Shruti; Mahajan, Rakesh Kumar

doi:10.1039/c7ra00075h

Cited by 36 publications

(18 citation statements)

References 62 publications

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“…After C 1 with increasing amount of [C 6 mim][C 12 OSO 3 ] the hydrophobic interactions between [C 6 mim][C 12 OSO 3 ] and TC were dominated over the hydrogen bonding between solvent molecules and the ground state which reduces energy gap and decreases intensity with red shift of maximum intensity ( λ 305.5 ). The intensity continues to decrease till cmc reached due to the increase in the amount of solubilized CPZ in micelles . These changes in band II of CPZ also confirm the complex formation between CPZ and [C 6 mim][C 12 OSO 3 ] favored by various interacting forces such as strong electrostatic interactions, hydrogen bonding, hydrophobic interactions and π‐π stacking interactions.…”

Section: Resultsmentioning

confidence: 56%

“…The intensity continues to decrease till cmc reached due to the increase in the amount of solubilized CPZ in micelles. [47] These changes in band II of CPZ also confirm the complex formation between CPZ and [C 6 mim][C 12 OSO 3 ] favored by various interacting forces such as strong electrostatic interactions, hydrogen bonding, hydrophobic interactions and p-p stacking interactions.…”

Section: Uv-visible Spectroscopymentioning

confidence: 52%

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Biamphiphilic Ionic Liquids‐Drug Mixtures: Interactional and Morphological Aspects

et al. 2018

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The interactional and morphology behavior of mixed system embracing chlorpromazine hydrochloride (CPZ) drug and surface active biamphiphilic ionic liquids (BAILs); 1‐hexyl‐3‐methylimidazolium dodecylsulfate ([C6mim][C12OSO3]) and 1‐butyl‐3‐methylimidazolium octylsulfate ([C4mim][C8OSO3]) at pH 7 have been investigated to develop new strategies to use BAILs as carriers of pharmaceutical active compounds. UV‐vis absorption spectroscopy and cyclic voltammetry (CV) methods are used to shed light on the foremost interactions governing CPZ + BAILs mixtures. The higher value of binding constant (Ka) and Gibbs free energy change (ΔG) for CPZ + [C6mim][C12OSO3] mixture, determined from absorbance measurements depict the existence of more attractive interactions than CPZ + [C4mim][C8OSO3]. The composition mediated self‐assembly of CPZ + BAIL mixed aggregates in bulk has been investigated by small angle neutron scattering (SANS), dynamic light scattering (DLS) and zeta potential measurements.

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Section: Resultsmentioning

confidence: 56%

Section: Uv-visible Spectroscopymentioning

confidence: 52%

Biamphiphilic Ionic Liquids‐Drug Mixtures: Interactional and Morphological Aspects

et al. 2018

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“…S3‐S5). The results of investigations revealed that both compounds 12 b and 13 c showed appreciable K a = 13.08 and 19.71 × 10 3 m −1 (Table S1), respectively, which indicates that 13 c ‐[DHPS] binding is stronger than 12 b ‐[DHPS].…”

Section: Resultsmentioning

confidence: 99%

4‐Substituted thieno[2,3‐d]pyrimidines as potent antibacterial agents: Rational design, microwave‐assisted synthesis, biological evaluation and molecular docking studies

et al. 2017

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In an attempt to discover a new class of antibacterial agents with improved efficacy and to overcome the drug-resistant problems, some novel 4-substituted thieno[2,3-d]pyrimidines have been synthesized via microwave-assisted methodology and evaluated for their in vitro antibacterial activity against various pathogenic bacterial strains. Compounds 12b and 13c showed the promising inhibitory potencies against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli with MICs ranging from 2 to 10 μg/ml. Compound 13c was also found to be highly potent against methicillin-resistant S. aureus (MRSA) with MIC value of 4 μg/ml. Docking simulation studies have been performed to unravel the mode of action and association study indicate the binding of potent compounds with DHPS enzyme. In silico ADME studies suggest the drug-like characteristics of the potent compounds.

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“…The IFT values between the crude oil and DIW containing different type of ILs at their CMC are given in Table . A wide range of CMC values from 7 mM to 16.8 mM have been previously reported in the literature for IL12, which is strongly dependent on the desired parameters including IFT, electrical conductivity (EC), H NMR spectroscopy, fluorescence, EMF and surface tension. − Consequently, it is necessary to determine the CMC value for each specific system and for a specific desired parameter. In this study, the CMC value for IL12 was about 4000 ppm (∼13.94 mM) in DIW, based on the IFT parameter.…”

Section: Results and Discussionmentioning

confidence: 99%

Mechanistic Investigation of the Synergy of a Wide Range of Salinities and Ionic Liquids for Enhanced Oil Recovery: Fluid–Fluid Interactions

et al. 2021

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In this paper, the performance of three imidazolium-based ionic liquids (ILs) including 1-hexyl-3-methylimidazolium chloride ([HMIM][Cl] or IL6), 1-octyl-3-methylimidazolium chloride ([OMIM][Cl] or IL8), and 1dodecyl-3-methylimidazolium chloride ([DMIM][Cl] or IL12) in reducing the interfacial tension (IFT) between crude oil and IL solutions was analyzed for the first time under a wide range of salinities (1000 to 195 476 ppm) at a reservoir temperature of 80 °C. The purpose was to microscopically analyze the occurring phenomenon at the fluid−fluid interface to determine the mechanism leading to oil extraction and to address the existing ambiguities in the literature concerning the synergism between ILs and different types/concentrations of ions. The quality of the synthesized ILs and their accumulation at the crude oil/IL solution interface was analyzed via attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, the IFT between crude oil and IL solutions was measured by the pendant drop method, and the micelles' size distribution and molecular diffusivity of the ILs in the aqueous solution was measured by the dynamic light scattering (DLS) technique. On the basis of the ATR-FTIR and IFT results, the accumulation of the ILs molecules at the interface of the crude oil/IL solution was a function of alkyl chain length and the ionic strength (IS) of solution; the longer alkyl chain ILs (i.e., IL12 in this study) accumulated more at the interface of the solution with more IS, leading to a more IFT reduction. At a constant but low range of salinities, the longer alkyl chain IL exhibited a lower IFT value in the presence of diluted seawater (dSW) than the diluted formation water (dFW). This is because of the higher concentration of divalent cations (Mg 2+ and Ca 2+ ) in dSW than dFW and their interactions with resin and asphaltene molecules and the salting-in effect mechanism that overcomes the lower saponification ability of dSW than dFW.

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Surface active ionic liquid induced conformational transition in aqueous medium of hemoglobin

Abstract: The molecular interactions and effect of SAILs on the conformation of human hemoglobin (Hb) has been studied using various techniques.

Cited by 36 publications

References 62 publications

Biamphiphilic Ionic Liquids‐Drug Mixtures: Interactional and Morphological Aspects

Biamphiphilic Ionic Liquids‐Drug Mixtures: Interactional and Morphological Aspects

4‐Substituted thieno[2,3‐d]pyrimidines as potent antibacterial agents: Rational design, microwave‐assisted synthesis, biological evaluation and molecular docking studies

Mechanistic Investigation of the Synergy of a Wide Range of Salinities and Ionic Liquids for Enhanced Oil Recovery: Fluid–Fluid Interactions

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