Surface-active ionic liquids: A review

Buettner, Cornelia S.; Cognigni, Alice; Schröder, Christian; Bica-Schröder, Katharina

doi:10.1016/j.molliq.2021.118160

Cited by 146 publications

(71 citation statements)

References 274 publications

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“…In the case of [C 2 C 1 Im][C 4 F 9 SO 3 ], an extra transition above the 3rd CAC was observed and was identified as a 4th CAC, but no description of the structure shape was made due to experimental limitations [ 38 ]. Hence, these FILs have improved aggregation behaviour when compared with the traditional surfactants, which commonly have only one critical micellar concentration (CMC, which in our case we identified as the 1st CAC) [ 30 ]. Taking advantage of these different aggregates, in this work, we evaluate the influence of IFN-α 2b on their behaviour and their proficiency as a drug delivery system for this protein.…”

Section: Resultsmentioning

confidence: 99%

“…ILs’ structure can be manipulated to obtain compounds with outstanding properties, increased biocompatibility and biodegradability, which have drawn the attention of several researchers to their biological activity [ 25 , 26 ]. The use of ILs as DDSs has been under investigation due to their capacity to stabilize and enhance the solubilization of macromolecules such as proteins [ 27 , 28 ], especially the surface-active ionic liquids (SAILs) [ 29 , 30 ]. Fluorinated ionic liquids (FILs) are a family of SAILs and have shown promising results in the biopharmaceutical field [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Disclosing the Potential of Fluorinated Ionic Liquids as Interferon-Alpha 2b Delivery Systems

et al. 2022

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Interferon-alpha 2b (IFN-α 2b) is a therapeutic protein used for the treatment of cancer, viral infections, and auto-immune diseases. Its application is hindered by a low bioavailability and instability in the bloodstream, and the search for new strategies for a target delivery and stabilization of IFN-α 2b to improve its therapeutic efficacy is crucial. Fluorinated ionic liquids (FILs) are promising biomaterials that: (i) can form self-assembled structures; (ii) have complete miscibility in water; and (iii) can be designed to have reduced toxicity. The influence of IFN-α 2b in the aggregation behaviour of FILs and the interactions between them were investigated through conductivity and surface tension measurements, and using electron microscopic and spectroscopy techniques to study FILs feasibility as an interferon-alpha 2b delivery system. The results show that the presence of IFN-α 2b influences the aggregation behaviour of FILs and that strong interaction between the two compounds occurs. The protein might not be fully encapsulated by FILs. However, the FIL can be tailored in the future to carry IFN-α 2b by the formation of a conjugate, which prevents the aggregation of this protein. This work constitutes a first step toward the design and development of FIL-based IFN-α 2b delivery systems.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Disclosing the Potential of Fluorinated Ionic Liquids as Interferon-Alpha 2b Delivery Systems

et al. 2022

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“…Ionic liquids are widely used in pharmaceuticals. The most important areas of application include using ILS as biologically active compounds (drugs or potential medicinal products); synthesis of active substances (catalysts, chemical reaction media, biotechnology); optimization of the bioavailability of medicinal products (elimination of polymorphism, improvement of the solubility of active substances (combinations of IL with known drugs), carriers of medicinal substances); and analysis of medicinal products (electrophoresis, chromatography, extraction) [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Cytotoxic Activity of Novel Imidazolium-Based Ionic Liquids

et al. 2022

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In this study, a series of 10 novel 1-methyl-3-octyloxymethylimidazolium derivatives carrying various anionic moieties (4-hydroxybenzenesulfonate, benzenesulfonate, carvacroloxyacetate, chloride, formate, propionate, thymoloxyacetate, vanillinoxyacetate, eugenoloxyacetate and trimethylacetate) were synthesized. Compounds were tested for their antimicrobial activity against six microbe strains (Staph-ylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis, and Candida albicans), cytotoxic activity against the mouse melanoma cell line (B16 F10), and surface active properties. All synthesized compounds exhibited antimicrobial activity (expressed as minimum inhibitory concentration; in range of 0.10–27.82 mM/L), especially against Gram-positive bacteria and fungi. In addition, all compounds demonstrated cytotoxicity on B16 F10 cells (IC50 values 0.0101–0.0197 mM/L). Surface properties defined as CMC values, ranged from 0.72 to 32.35 mmol L-1. The obtained results provide an insight into the promising activity of a novel group of quaternary imidazolium derivatives having ionic liquid properties. The most potent compounds, containing a thymoloxyacetate and eugenoloxyacetate moiety, could be candidates for new antimicrobial agents or surfactants.

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“…The hydrophilic ionic liquid 1-ethyl-3-methylimidazolium hydrogensulfate [C 2 mim][HSO 4 ] was selected on the basis of price, commercial availability and its lower toxicity than other aprotic ionic liquids [25][26][27][28]. The alcohols ranging from C 4 -C 12 are completely miscible with n-tetradecane under the experimental conditions employed.…”

Section: Resultsmentioning

confidence: 99%

Separation of Alcohols from n-Tetradecane Using 1-Ethyl-3-methylimidazolium Hydrogensulfate

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et al. 2022

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Extraction of alcohols from n-tetradecane using various extraction solvents has been investigated at a range of temperatures from 295 to 393 K under ambient pressure. On the basis of the experimental liquid–liquid equilibrium data, the distribution ratio and selectivity were calculated for the extraction of 1-octanol, 1-decanol, and 1-dodecanol (C8–C12) in 1-ethyl-3-methylimidazolium hydrogensulfate [C2mim][HSO4] and sulfolane. Results showed that moderate selectivities were obtained in sulfolane with very low distribution coefficients. In contrast, [C2mim][HSO4] showed similar selectivity values with higher distribution coefficients. A study of a number of different 1-alcohols (C4–C12) showed that the decrease in hydrogen bonding compared to the increased van der Waals interactions between n-tetradecane and the higher-chain alcohols decreased the extraction selectivity in [C2mim][HSO4]. Increasing the temperature of the ionic liquid extraction medium resulted in increased chemical extraction for 1-butanol and 1-hexanol due to the formation of the corresponding alkylsulfate ionic liquid. In contrast, the selectivity decreased for 1-octanol, 1-decanol and 1-dodecanol due to the partial dissolution of the corresponding alkylsulfate ionic liquid into the n-tetradecane phase.

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Surface-active ionic liquids: A review

Cited by 146 publications

References 274 publications

Disclosing the Potential of Fluorinated Ionic Liquids as Interferon-Alpha 2b Delivery Systems

Disclosing the Potential of Fluorinated Ionic Liquids as Interferon-Alpha 2b Delivery Systems

Antimicrobial and Cytotoxic Activity of Novel Imidazolium-Based Ionic Liquids

Separation of Alcohols from n-Tetradecane Using 1-Ethyl-3-methylimidazolium Hydrogensulfate

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