Surface activity and cutaneous effects of monoalkyl phosphate surfactants

Imokawa, Genji; Tsutsumi, Hisao; Kurosaki, Tomoaki

doi:10.1007/bf02682659

Cited by 47 publications

(45 citation statements)

References 7 publications

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“…As a consequence of how the polymer is synthesized, there are primary alcohols at the chain ends as well as secondary alcohols near the hydrophobic core, both of which are potential sites for functionalization with phosphate. Faced with a variety of potential chemistries by which phosphate could be covalently attached to PEG 15-20, we chose the reaction with phosphorus oxychloride (POCl 3 ) and subsequent hydrolysis with water to give phosphate groups at available alcoholic sites (23)(24)(25). This route is advantageous in that the high reactivity of phosphorus oxychloride helps to overcome problems associated with end-functionalization of higher-molecular-weight polymers and facilitates near-complete reaction of chain ends of the polymers synthesized in this manner.…”

Section: Synthesis Of Pi-peg 15-20mentioning

confidence: 99%

Phosphate-Containing Polyethylene Glycol Polymers Prevent Lethal Sepsis by Multidrug-Resistant Pathogens

Zaborin

DeFazio

Kade

et al. 2014

Antimicrob Agents Chemother

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Antibiotic resistance among highly pathogenic strains of bacteria and fungi is a growing concern in the face of the ability to sustain life during critical illness with advancing medical interventions. The longer patients remain critically ill, the more likely they are to become colonized by multidrug-resistant (MDR) pathogens. The human gastrointestinal tract is the primary site of colonization of many MDR pathogens and is a major source of life-threatening infections due to these microorganisms. Eradication measures to sterilize the gut are difficult if not impossible and carry the risk of further antibiotic resistance. Here, we present a strategy to contain rather than eliminate MDR pathogens by using an agent that interferes with the ability of colonizing pathogens to express virulence in response to hostderived and local environmental factors. The antivirulence agent is a phosphorylated triblock high-molecular-weight polymer (here termed Pi-PEG 15-20) that exploits the known properties of phosphate (P i ) and polyethylene glycol 15-20 (PEG 15-20) to suppress microbial virulence and protect the integrity of the intestinal epithelium. The compound is nonmicrobiocidal and appears to be highly effective when tested both in vitro and in vivo. Structure functional analyses suggest that the hydrophobic bis-aromatic moiety at the polymer center is of particular importance to the biological function of Pi-PEG 15-20, beyond its phosphate content. Animal studies demonstrate that Pi-PEG prevents mortality in mice inoculated with multiple highly virulent pathogenic organisms from hospitalized patients in association with preservation of the core microbiome.

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Section: Synthesis Of Pi-peg 15-20mentioning

confidence: 99%

Phosphate-Containing Polyethylene Glycol Polymers Prevent Lethal Sepsis by Multidrug-Resistant Pathogens

Zaborin

DeFazio

Kade

et al. 2014

Antimicrob Agents Chemother

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show abstract

“…These cac values are much lower than that measured for the monomeric surfactant sodium dodecyl phosp h a t e , 3 . 5 m m o l d m 3 i n t h e a b s e n c e o f a d d e d electrolytes 9 . Indeed, on the basis of Gibbs adsorption analysis, the occupied area per surfactant molecule adsorbed at the air/aqueous solution interface is estimated to be decreased with increasing chain length.…”

Section: Oleic Acid-based Gemini Surfactantsmentioning

confidence: 99%

Recent Advances in Gemini Surfactants: Oleic Acid-Based Gemini Surfactants and Polymerizable Gemini Surfactants

Sakai

Abe

2011

J. Oleo Sci.

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“…[8] versus , where the slope is equal to ϪB and the y-intercept is equal to Ϫ⌬G ads°/ RT. Once values of B and ⌬G ads°w ere determined (see Table 3), theoretical isotherms based on Eq.…”

Section: Figmentioning

confidence: 99%

“…Once values of B and ⌬G ads°w ere determined (see Table 3), theoretical isotherms based on Eq. [8] using the IGOR program were calculated. The parameter B was held constant (while was allowed to vary) in order to avoid producing lines of "good fit" with physically unrealistic parameters.…”

Section: Figmentioning

confidence: 99%