The degradation of 405-nm fiber-coupled diode laser systems with more than 50 mW power was investigated in detail with focus on the effects occurring at the input end. The coupling and transmission loss of the laser light were associated with the growth of a projection and a periodic structure on the input surface. To avoid this degradation, a short launch fiber with a good surface quality was used at the input end. In this way, the power transmission was stabilized for at least one month. However, structural degradation was noticed on the output surface of the single-mode fiber. To investigate this effect, the damaged samples were measured after different periods of time and examined with a scanning electron microscope and with an atomic force microscope. Reproducible spherical projections with a submicron periodic structure were found in the core region. Additionally, the spectral loss of the fiber was measured, showing the formation of color centers in the deep ultraviolet along the length of the fiber. These investigations were accompanied by simulations of the growth of the structure on the output surface. The influence of the structure was mainly on the divergence angle of the emitted laser beam, reducing the beam quality for applications