Surface applicator high-dose-rate fractionated brachytherapy for superficial cancers of the penis: A single-center case series and national database comparison

Dee, Edward Christopher; Fefer, Maia; Hammoudeh, Lubna; Yu, Zizi; Cantalino, Jonathan; Johnson, Thomas J.; O’Farrell, Desmond A.; Bui, Ai-Tram N.; Muralidhar, Vinayak; Mahal, Brandon A.; Nguyen, Paul L.; LeBoeuf, Nicole R.; Devlin, Phillip M.

doi:10.1016/j.jaad.2020.04.041

Cited by 3 publications

(5 citation statements)

References 4 publications

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“…1 Herein, three patients were treated successfully with HDR-BT for EMPD. For our three patients and six known cases of EMPD treated with HDR-BT in the literature, all nine patients sustained clinical remission during a median follow-up of 18 months (range 6-45.7) [4][5][6][7] ; nonetheless, this finding is subject to reporting bias and larger studies are warranted. Our series supports HDR-BT as a possible treatment for EMPD, particularly for cases nonamenable to surgery.…”

Section: Casementioning

confidence: 86%

Recalcitrant extramammary Paget's disease treated successfully with high‐dose‐rate brachytherapy: A case series and review of the literature

Bui

Dee

Virgen

et al. 2021

Dermatologic Therapy

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There is a paucity in guidelines for the management of extramammary Paget's disease (EMPD), a rare intraepithelial adenocarcinoma commonly involving the anogenital regions. 1 Wide surgical resection is the mainstay therapy but causes significant morbidity. 1 High-dose-rate brachytherapy (HDR-BT), a form of radiotherapy, delivers a high, conformal radiation dose to the target tissue through flexible catheters secured within customized surface molds. 2 We report three patients successfully treated with HDR-BT for their biopsy-confirmed and skin-limited EMPD and review cases treated with this method in the literature (Table 1).

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Section: Casementioning

confidence: 86%

Recalcitrant extramammary Paget's disease treated successfully with high‐dose‐rate brachytherapy: A case series and review of the literature

Bui

Dee

Virgen

et al. 2021

Dermatologic Therapy

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“…7 13 There are few reports showing good results of BT in well-selected early cases of carcinoma penis. 12 13 14 Dee et al presented a case series of 12 patients treated by surface mold technique. 12 They used customized wrapper applicators, which were fit circumferentially and longitudinally around the penile shaft using super flap bolus material.…”

Section: Discussionmentioning

confidence: 99%

“…Case series by Dee et al demonstrates that it can also be applied to myriad metastases, as a palliative procedure, expanding the role for penile BT. 12 As urethra receives minimal dose contribution from the sources, the urethral stricture is not a concern.…”

Section: Discussionmentioning

confidence: 99%

“…12 13 14 Dee et al presented a case series of 12 patients treated by surface mold technique. 12 They used customized wrapper applicators, which were fit circumferentially and longitudinally around the penile shaft using super flap bolus material. The results were rewarding with eight patients considered disease-free.…”

Section: Discussionmentioning

confidence: 99%

“…10,11 In a superficial tumor, the fibrosis, urethral stenosis, and sexual dysfunction usually associated with interstitial BT can be avoided by using the surface mold applicator technique. 7,12,13 These surface mold applicators need to be individually customized depending on the location and extent of disease.…”

Section: Introductionmentioning

confidence: 99%

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Step-by-Step Guide to Surface Mold Applicator-Based Brachytherapy in a Case of Early Carcinoma Penis: An Organ-Preserving Approach

Thakur

Gupta

et al. 2022

ASJO

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Purpose In this report we discuss an individually customized surface mold applicator technique to treat a case of early carcinoma penis. This case report is one of its kind which describes the brachytherapy treatment planning based on orthogonal X-ray technique. Material and methods T1N0 disease with squamous cell carcinoma histology involving the foreskin of penis and abutting the glans penis was treated by surface mold applicator technique. Impression of the organ was taken using alginate. Cast was prepared from the impression using Type 4 gypsum. The acrylic mold-based applicator was fabricated on the cast. The catheters were positioned and fixed on the acrylic mold. The organ is placed in the mold-based applicator and the catheters are reconstructed on two-dimensional imaging. The brachytherapy is delivered by the 18-channel high-dose rate Oncentra brachytherapy using Ir192 source. The dose given was 45 Gy in 15 fractions, twice daily more than 6 hours apart. Results Patient was reviewed after 6 weeks for follow-up and there was complete regression of the ulcer. At present, patient is on follow-up for the last 10 months and is now disease-free. Conclusion With judicious patient selection, surface mold brachytherapy is an attractive alternative to the interstitial brachytherapy. It is comfortable for the patient, is easily repeatable, and is time saving in high work load and limited resource settings. Early results with this technique are promising.

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Radiotherapy-activated tumor immune microenvironment: Realizing radiotherapy-immunity combination therapy strategies

Luo,

Ma,

Chen

et al. 2023

Nano Today

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Surface applicator high-dose-rate fractionated brachytherapy for superficial cancers of the penis: A single-center case series and national database comparison

Cited by 3 publications

References 4 publications

Recalcitrant extramammary Paget's disease treated successfully with high‐dose‐rate brachytherapy: A case series and review of the literature

Recalcitrant extramammary Paget's disease treated successfully with high‐dose‐rate brachytherapy: A case series and review of the literature

Step-by-Step Guide to Surface Mold Applicator-Based Brachytherapy in a Case of Early Carcinoma Penis: An Organ-Preserving Approach

Radiotherapy-activated tumor immune microenvironment: Realizing radiotherapy-immunity combination therapy strategies

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