Surface attached manganese–oxo clusters as potential contrast agents

Mertzman, Julie E.; Kar, Srotoswini; Lofland, S. E.; Fleming, Travis; Keuren, Edward Van; Tong, YuYe J.; Stoll, Sarah L.

doi:10.1039/b815424d

Cited by 27 publications

(21 citation statements)

References 31 publications

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“…50–53 Mertzman et al recently showed that manganese-oxo clusters offer promise as an MRI contrast agent and their magnetic properties and water solubility are improved when they were conjugated onto the surface of polymer (e.g., polystyrene) beads (Figure 3). 54 Mn-oxo cluster has a large number of unpaired electrons and has four coordinated waters that are exchanged rapidly on the NMR timescale due to the coordination to the labile Mn(III). It can undergo ligand exchange for attachment onto any surface containing carboxylic acid functionality.…”

Section: Contrast Agent Familiesmentioning

confidence: 99%

Manganese-based MRI contrast agents: past, present, and future

Pan¹,

Schmieder²,

Wickline³

et al. 2011

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288

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Paramagnetic and superparamagnetic metals are used as contrast materials for magnetic resonance (MR) based techniques. Lanthanide metal gadolinium (Gd) has been the most widely explored, predominant paramagnetic contrast agent until the discovery and association of the metal with nephrogenic systemic fibrosis (NSF), a rare but serious side effects in patients with renal or kidney problems. Manganese was one of the earliest reported examples of paramagnetic contrast material for MRI because of its efficient positive contrast enhancement. In this review, manganese based contrast agent approaches are discussed with a particular emphasis on their synthetic approaches. Both small molecules based typical blood pool contrast agents and more recently developed novel nanometer sized materials are reviewed focusing on a number of successful molecular imaging examples.

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Section: Contrast Agent Familiesmentioning

confidence: 99%

Manganese-based MRI contrast agents: past, present, and future

Pan¹,

Schmieder²,

Wickline³

et al. 2011

Tetrahedron

356

288

View full text Add to dashboard Cite

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“…5), as expected from Eq. (9). As the width increases, there are probabilities of selecting much lower values of D than D 0 .…”

Section: B Distributions Of Magnetic Anisotropy Dmentioning

confidence: 99%

“…This was motivated by their applications for magnetic storage media [4,5], biosensors [6], and contrast agents in magnetic resonance imaging [7][8][9]. Ideally, for a given system, magnetic nanoparticles may have uniform particle sizes and shapes, and molecules may have identical ligand orientations.…”

mentioning

confidence: 99%

Effect of the size distribution of magnetic nanoparticles on metastability in magnetization relaxation

Yamamoto

Park

2011

Phys. Rev. B

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We theoretically examine metastability occurring in magnetization relaxation for magnetic nanoparticles with size distributions. An array of magnetic nanoparticles is simulated using a spin S=1 ferromagnetic Blume-Capel model on a square lattice. The particle size distributions give rise to distributions of magnetic anisotropy. Including the distributions, we perform kinetic Monte Carlo simulations of magnetization relaxation at low temperatures for the Blume-Capel model. We compute the average lifetime of the metastable state from the simulations and the absorbing Markov chains method in the low temperature limit. We also carry out similar simulations and calculations for a constant value of magnetic anisotropy for comparison. Our results suggest that the lifetime of the metastable state is determined by the smallest particle for a given system, and that the lifetime with size distributions obeys a modified Arrhenius-like law, where the energy barrier depends on even temperature and standard deviation of the distributions as well as magnetic field and magnetic anisotropy.

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“…A few approaches were proposed including binding the clusters to polystyrene beads and an emulsion-assisted self-assembly method for dispersing stearic acid modified Mn 12 . 12 While these were viable approaches to use SMM as a T2 weighted (darkening contrast) MRI agent, a more biocompatible, robust methodology is required to use it as a T1 weighted agent (brightening contrast) to diagnose vascular disease. We hypothesized that the induced magnetic moment of Mn 12 clusters in the applied field would accelerate the relaxation of surrounding water protons.…”

mentioning

confidence: 99%

Sensitive Biological Detection with a Soluble and Stable Polymeric Paramagnetic Nanocluster

et al. 2012

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We describe the design, synthesis and biological characterization of manganese oxocluster-based “single molecule magnets (SMMs)”. We demonstrate that polymeric micellar nanoparticles can serve as a carrier and help to stabilize delicate SMM molecules from breaking down easily and thus prevent their property loss. Concentrating thousands of Mn-clusters per micelle provided a high ionic and per-particle relaxivity allowing sensitive MR imaging in vivo. This reports one of the earliest examples of in vivo imaging of a rationally designed polymeric micelles that features SMM.

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Surface attached manganese–oxo clusters as potential contrast agents

Abstract: Surface attachment of the manganese-oxo cluster known as Mn-12 provided aqueous solution stabilization that allowed investigation of the use of the cluster as an MRI contrast agent.

Cited by 27 publications

References 31 publications

Manganese-based MRI contrast agents: past, present, and future

Manganese-based MRI contrast agents: past, present, and future

Effect of the size distribution of magnetic nanoparticles on metastability in magnetization relaxation

Sensitive Biological Detection with a Soluble and Stable Polymeric Paramagnetic Nanocluster

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