Surface Characterisation of Bioadhesive PLGA/Chitosan Microparticles Produced by Supercritical Fluid Technology

Casettari, Luca; Castagnino, Enzo; Stolnik, Snow; Lewis, Andrew L.; Howdle, Steven M.; Illum, Lisbeth

doi:10.1007/s11095-011-0403-z

Cited by 35 publications

(11 citation statements)

References 49 publications

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“…The research proved that after intravenous injection, grain size at 7~30 μm can be mechanically intercepted by capillary bed and then accumulate in the lungs. Casettari and others found that positively charged particles and reach lungs easily [25]. The microspheres made by this research had an average grain diameter of 9.6 μm.…”

Section: Resultsmentioning

confidence: 69%

Docetaxel-Loaded Chitosan Microspheres as a Lung Targeted Drug Delivery System: In Vitro and in Vivo Evaluation

Wang

Zhou

2014

IJMS

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The aim of this study was to prepare docetaxel-loaded chitosan microspheres and to evaluate their in vitro and in vivo characteristics. Glutaraldehyde crosslinked microspheres were prepared using a water-in-oil emulsification method, and characterized in terms of the morphological examination, particle size distribution, encapsulation ratio, drug-loading coefficient and in vitro release. Pharmacokinetics and biodistribution studies were used to evaluate that microspheres have more advantage than the conventional formulations. The emulsion crosslinking method was simple to prepare microspheres and easy to scale up. The formed microspheres were spherical in shape, with a smooth surface and the size was uniform (9.6 ± 0.8 μm); the encapsulation efficiency and drug loading of prepared microspheres were 88.1% ± 3.5% and 18.7% ± 1.2%, respectively. In vitro release indicated that the DTX microspheres had a well-sustained release efficacy and in vivo studies showed that the microspheres were found to release the drug to a maximum extent in the target tissue (lung). The prepared microspheres were found to possess suitable physico-chemical properties and the particle size range. The sustained release of DTX from microspheres revealed its applicability as drug delivery system to minimize the exposure of healthy tissues while increasing the accumulation of therapeutic drug in target sites.

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Section: Resultsmentioning

confidence: 69%

Docetaxel-Loaded Chitosan Microspheres as a Lung Targeted Drug Delivery System: In Vitro and in Vivo Evaluation

Wang

Zhou

2014

IJMS

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“…For example, protein loaded lipid micro particles were produced and reported by Salas et al [23]. Casettari et al report the use of PASS for the development of mucoadhesive particles form chitosan and poly-lactic acid for gastrointestinal drug delivery [24]. Falconer et al present a multivariate study on the effect of different operating conditions for the preparation of progesterone loaded gelucire particles and the results demonstrate that not only the independent variables of pressure and temperature influence the result but also the interaction between them influence the yield of the process [25].…”

Section: Particle Formation/encapsulationmentioning

confidence: 99%

Supercritical CO2 for the Reactive Precipitation of Calcium Carbonate: Uses and Applications to Industrial Processing

Duarte

Mano²,

Reis³

2015

Supercritical Fluid Nanotechnology

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“…Under these conditions, the Maillard reaction took place as well. Biodegradable and mucoadhesive PLGA/chitosan microparticles were manufactured by Casettari et al [104] by using scCO 2 with the addition of mPEG and chitosan in the absence of organic solvents, surfactants and crosslinkers. Analytical surface techniques, along with the interaction with mucin, demonstrated the presence of the chitosan (<100 μm) on the surface of the particles.…”

Section: Supercritical Dryingmentioning

confidence: 99%

Biomedical Exploitation of Chitin and Chitosan via Mechano-Chemical Disassembly, Electrospinning, Dissolution in Imidazolium Ionic Liquids, and Supercritical Drying

Müzzarelli

2011

Marine Drugs

185

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Recently developed technology permits to optimize simultaneously surface area, porosity, density, rigidity and surface morphology of chitin-derived materials of biomedical interest. Safe and ecofriendly disassembly of chitin has superseded the dangerous acid hydrolysis and provides higher yields and scaling-up possibilities: the chitosan nanofibrils are finding applications in reinforced bone scaffolds and composite dressings for dermal wounds. Electrospun chitosan nanofibers, in the form of biocompatible thin mats and non-wovens, are being actively studied: composites of gelatin + chitosan + polyurethane have been proposed for cardiac valves and for nerve conduits; fibers are also manufactured from electrospun particles that self-assemble during subsequent freeze-drying. Ionic liquids (salts of alkylated imidazolium) are suitable as non-aqueous solvents that permit desirable reactions to occur for drug delivery purposes. Gel drying with supercritical CO2 leads to structures most similar to the extracellular matrix, even when the chitosan is crosslinked, or in combination with metal oxides of interest in orthopedics.

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Surface Characterisation of Bioadhesive PLGA/Chitosan Microparticles Produced by Supercritical Fluid Technology

Abstract: The strong interaction of mucin with the chitosan present on the surface of the particles suggests a potential use of the mucoadhesive carriers for gastroretentive and oral controlled drug release.

Cited by 35 publications

References 49 publications

Docetaxel-Loaded Chitosan Microspheres as a Lung Targeted Drug Delivery System: In Vitro and in Vivo Evaluation

Docetaxel-Loaded Chitosan Microspheres as a Lung Targeted Drug Delivery System: In Vitro and in Vivo Evaluation

Supercritical CO2 for the Reactive Precipitation of Calcium Carbonate: Uses and Applications to Industrial Processing

Biomedical Exploitation of Chitin and Chitosan via Mechano-Chemical Disassembly, Electrospinning, Dissolution in Imidazolium Ionic Liquids, and Supercritical Drying

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