Surface characteristics of holmium-loaded poly(l-lactic acid) microspheres

Zielhuis, S.W.; Nijsen, J. Frank W.; Figueiredo, Roberto B.; Feddes, B.; Vredenberg, A. M.; Schip, Alfred D. van het; Hennink, Wim E.

doi:10.1016/j.biomaterials.2004.03.028

Cited by 31 publications

(17 citation statements)

References 25 publications

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“…The sieve fractions were dried at 40°C. The particle size was determined using a Coulter Counter, and the holmium content was determined using the complexometric titration as described by Zielhuis et al [20]. Sixty mg HoAcAcMS was transferred to a high-density poly-ethylene vial (Posthumus Plastics, the Netherlands), and neutron irradiated for one hour with a thermal neutron flux of 5×10 12 n cm −2 s −1 , using the pneumatic rabbit system in a nuclear reactor (Reactor Institute Delft, the Netherlands) to render the MS radioactive.…”

Section: Methodsmentioning

confidence: 99%

Intratumoral Administration of Holmium-166 Acetylacetonate Microspheres: Antitumor Efficacy and Feasibility of Multimodality Imaging in Renal Cancer

et al. 2013

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PurposeThe increasing incidence of small renal tumors in an aging population with comorbidities has stimulated the development of minimally invasive treatments. This study aimed to assess the efficacy and demonstrate feasibility of multimodality imaging of intratumoral administration of holmium-166 microspheres (166HoAcAcMS). This new technique locally ablates renal tumors through high-energy beta particles, while the gamma rays allow for nuclear imaging and the paramagnetism of holmium allows for MRI.Methods 166HoAcAcMS were administered intratumorally in orthotopic renal tumors (Balb/C mice). Post administration CT, SPECT and MRI was performed. At several time points (2 h, 1, 2, 3, 7 and 14 days) after MS administration, tumors were measured and histologically analyzed. Holmium accumulation in organs was measured using inductively coupled plasma mass spectrometry.Results 166HoAcAcMS were successfully administered to tumor bearing mice. A striking near-complete tumor-control was observed in 166HoAcAcMS treated mice (0.10±0.01 cm3 vs. 4.15±0.3 cm3 for control tumors). Focal necrosis and inflammation was present from 24 h following treatment. Renal parenchyma outside the radiated region showed no histological alterations. Post administration CT, MRI and SPECT imaging revealed clear deposits of 166HoAcAcMS in the kidney.ConclusionsIntratumorally administered 166HoAcAcMS has great potential as a new local treatment of renal tumors for surgically unfit patients. In addition to strong cancer control, it provides powerful multimodality imaging opportunities.

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Section: Methodsmentioning

confidence: 99%

Intratumoral Administration of Holmium-166 Acetylacetonate Microspheres: Antitumor Efficacy and Feasibility of Multimodality Imaging in Renal Cancer

et al. 2013

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“…GA‐loaded PDLLA microspheres were prepared by a solvent evaporation method as described previously 22. GA (0.6 g) and PDLLA powder (2 g) were dissolved in methylene dichloride (62 g).…”

Section: Methodsmentioning

confidence: 99%

Study on poly(D,L‐lactic) microspheres embedded in calcium alginate hydrogel beads as dual drug delivery systems

Zhong

Liu

Xie

et al. 2012

J of Applied Polymer Sci

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This work is to develop a novel dual drug delivery system that can simultaneously load and release 18β‐glycyrrhetinic acid (GA, a hydrophobic drug) and bovine serum albumin (BSA, hydrophilic model drug) in a single formulation. The system consists of poly(D,L‐lactic) (PDLLA) microspheres embedded in calcium alginate hydrogel beads. The GA‐loaded microspheres were first prepared and then dispersed in the aqueous solution of sodium alginate and BSA. The resulting suspension was dropped into aqueous calcium chloride solution to obtain the dual drug delivery system. The morphology of the microspheres and beads, the drug content and loading efficiency, the interaction between GA and PDLLA, and the drug release behaviors were studied. Scanning electron microscope (SEM) revealed that the PDLLA microspheres were homogeneously distributed in the beads. Differential scanning calorimetry (DSC) measurement suggested certain interaction between GA and PDLLA, and the crystal structure of GA was influenced by the polymer. The dual release in vitro showed a rapid BSA release but a sustained GA release in all the systems. Furthermore, the release rate of BSA was accelerated by increasing PDLLA/alginate ratio, while the release rate of GA was decreased, and the release of both hydrophobic and hydrophilic drugs could be adjusted by changing the ratio of PDLLA/alginate. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 20122

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“…The high-resolution C1s spectra revealed three component peaks ( Table 3) [50][51][52]. The PLLA coatings show some variation from this ratio.…”

Section: Ring Opening Polymerisation Of L-lactide On Psi Filmsmentioning

confidence: 99%

New biodegradable materials produced by ring opening polymerisation of poly(l-lactide) on porous silicon substrates

McInnes

Thissen

Choudhury

et al. 2009

Journal of Colloid and Interface Science

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Surface characteristics of holmium-loaded poly(l-lactic acid) microspheres

Cited by 31 publications

References 25 publications

Intratumoral Administration of Holmium-166 Acetylacetonate Microspheres: Antitumor Efficacy and Feasibility of Multimodality Imaging in Renal Cancer

Intratumoral Administration of Holmium-166 Acetylacetonate Microspheres: Antitumor Efficacy and Feasibility of Multimodality Imaging in Renal Cancer

Study on poly(D,L‐lactic) microspheres embedded in calcium alginate hydrogel beads as dual drug delivery systems

New biodegradable materials produced by ring opening polymerisation of poly(l-lactide) on porous silicon substrates

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