Surface characterization, in vitro and in vivo biocompatibility of Mg-0.3Sr-0.3Ca for temporary cardiovascular implant

Bornapour, Mosayeb; Mahjoubi, Hesameddin; Vali, Hojatollah; Shum‐Tim, Dominique; Cerruti, Marta; Pekguleryuz, Mihriban

doi:10.1016/j.msec.2016.04.108

Cited by 38 publications

(24 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…. . clude right coronary artery (RCA), left anterior descending (LAD) and left anterior circumflex (LCX) in the consideration of mimicking the most frequent clinical cardiovascular occlusions, as well as the other sites such as abdominal aorta [30], femoral artery [13,26,31] iliac artery [32], renal artery [32] and so on.…”

Section: Animal Studies: Implantation Models Characterization Methodmentioning

confidence: 99%

“…Histopathology of stented arteries segments shows the situation of re-endothelialization, restenosis, and inflammation, and the main process includes tissue fixation, embedding, cutting slices and staining. It is noteworthy that some researchers reported a novel tissue fixation method, in which the stented arteries were in situ fixed with 10% buffered formaldehyde solution perfused at 100 mm Hg for 15-30 min after an overdose of anesthesia and then removed for further conducts [26,31,35,36,39,124].…”

Section: Animal Studies: Implantation Models Characterization Methodmentioning

confidence: 99%

“…However, protein adsorption on the sample surface retards the degradation in vivo. Pretreatment of Mg-based samples is a critical step for initial cell adhesion and survival on sample surfaces in the direct culture assays [26,51,69,71,79]. The pretreatment usually consists of a 24 h incubation at 37°C, 5% CO 2 , in solutions like simulated body fluid (SBF) and Dulbecco's Modified eagle medium (DMEM).…”

Section: Direct Culture Assaysmentioning

confidence: 99%

“…Besides this, there should be also no or only mild inflammatory reaction during the implantation period. In terms of biodegradable Mg-based stents, relatively high concentrations of Mg ions are released inevitably, thus the influence of the released Mg ions on these cells is necessary to be assessed in in vitro tests [25,26].…”

Section: Introductionmentioning

confidence: 99%

“…For in vivo animal studies, the different candidate Mg-based stents were implanted into the arteries without atherosclerotic lesion at various sites. Most of the results were positive about the cellular and tissue response surrounding the stents [13,26,[29][30][31][32][33][34][35][36][37][38][39][40]. It means that the applications of Mg-based stents in the vessels are safe for the body.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

In vitro and in vivo cytocompatibility evaluation of biodegradable magnesium-based stents: a review

et al. 2018

View full text Add to dashboard Cite

Biodegradable magnesium (Mg)-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood flow. Numerous studies have presented in vitro and in vivo tests for the evaluation of the safety and feasibility of Mg-based vascular stents and the related materials. Therein the cytocompatibility is a basic and important parameter in the evaluation system. In this review, we summarize the applications and limitations of in vitro evaluation methods including basic characterization methods and direct and indirect cytotoxicity tests. We discuss the influencing factors on cytotoxicity, such as surface roughness, preconditioning of sample surface, cell type for the biocompatibility evaluation in direct contact as well as conditions for the formation of extracts/ degradation products for indirect assays. Besides, we highlight the recent in vivo animal tests and clinical trials about Mgbased stents along with some associated results. The aim of this review is to provide a meaningful reference in the further developments and related evaluation methods of Mg-based stents.

show abstract

Section: Animal Studies: Implantation Models Characterization Methodmentioning

confidence: 99%

Section: Animal Studies: Implantation Models Characterization Methodmentioning

confidence: 99%

Section: Direct Culture Assaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

In vitro and in vivo cytocompatibility evaluation of biodegradable magnesium-based stents: a review

et al. 2018

View full text Add to dashboard Cite

show abstract

Designing Better Cardiovascular Stent Materials: A Learning Curve

Cockerill

See

Young

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

Cardiovascular stents are life‐saving devices and one of the top ten medical breakthroughs of the 21st century. Decades of research and clinical trials have taught us about the effects of material (metal or polymer), design (geometry, strut thickness, and the number of connectors), and drug‐elution on vasculature mechanics, hemocompatibility, biocompatibility, and patient health. Recently developed novel bioresorbable stents are intended to overcome common issues of chronic inflammation, in‐stent restenosis, and stent thrombosis associated with permanent stents, but there is still much to learn. Increased knowledge and advanced methods in material processing have led to new stent formulations aimed at improving the performance of their predecessors but often comes with potential tradeoffs. This review aims to discuss the advantages and disadvantages of stent material interactions with the host within five areas of contrasting characteristics, such as 1) metal or polymer, 2) bioresorbable or permanent, 3) drug elution or no drug elution, 4) bare or surface‐modified, and 5) self‐expanding or balloon‐expanding perspectives, as they relate to pre‐clinical and clinical outcomes and concludes with directions for future studies.

show abstract

NIR‐II J‐Aggregates Labelled Mesoporous Implant for Imaging‐Guided Osteosynthesis with Minimal Invasion

Sun

Pei

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Medical implants are widely used in clinical practice, such as cardiovascular stenting, maxillofacial surgery, and orthopedics. However, most of the traditional implant operations are open and invasive, resulting in massive dissection of soft tissue and interruption of blood supply. The accurate navigation for the implant operations is considered as one of the most effective ways to reduce the damage, which is urgently desired in clinic. Herein, a biocompatible NIR-II J-aggregates labelled mesoporous implant for imaging-guided osteosynthesis with minimal invasion is reported. Mesoporous silica layer with vertical channels is grown on the surface of titanium plate, which can provide the confining space for the formation of the FD-1080 J-aggregates. Both the absorption and fluorescence peaks of the FD-1080 J-aggregates are located in NIR-II window (beyond 1300 nm), which are ideal for high resolution and real time surgical navigation in deep tissue. NIR-II imaging can clearly display the location and outline of the implant both in vitro and in vivo. This NIR-II imaging-guided osteosynthesis can effectively reduce the surgical wound and operational duration, which is crucial for the implant surgeries.

show abstract

Surface characterization, in vitro and in vivo biocompatibility of Mg-0.3Sr-0.3Ca for temporary cardiovascular implant

Cited by 38 publications

References 55 publications

In vitro and in vivo cytocompatibility evaluation of biodegradable magnesium-based stents: a review

In vitro and in vivo cytocompatibility evaluation of biodegradable magnesium-based stents: a review

Designing Better Cardiovascular Stent Materials: A Learning Curve

NIR‐II J‐Aggregates Labelled Mesoporous Implant for Imaging‐Guided Osteosynthesis with Minimal Invasion

Contact Info

Product

Resources

About