Surface charge-convertible quaternary ammonium salt-based micelles for in vivo infection therapy

He, Dengfeng; Tan, Yifeng; Li, Pengfei; Luo, Yadong; Zhu, Yuhong; Yu, Yunlong; Chen, Jiali; Ning, Ning; Zhang, Shiyong

doi:10.1016/j.cclet.2020.12.034

Cited by 23 publications

(14 citation statements)

References 42 publications

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“…This result strongly validates the effectiveness of the pH-triggered aggregation of Ag-P&C NPs. Ag NP adhesion can be significantly promoted by electrostatic attraction between the negatively charged bacterial cell membrane [26] and Ag-peptide NPs due to protonation of the imidazole groups of histidine. [1b]…”

Section: Evaluation Of the Bacterial Integrity Disruptionmentioning

confidence: 99%

pH‐Triggered Size‐Tunable Silver Nanoparticles: Targeted Aggregation for Effective Bacterial Infection Therapy

Cheng

Pei

Xie

et al. 2022

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The rapid spread of drug‐resistant pathogens threatens human health. To address the current antibacterial dilemma, the development of antibiotic‐free strategies using nanotechnology is imperative. In this study, silver nanoparticles (Ag‐P&C NPs) with pH‐sensitive charge reversal and self‐aggregation capacities are successfully synthesized. In the acidic microenvironment of bacterial biofilms, protonation of the surface peptide enhances the affinity of Ag‐P&C NPs for bacteria, which can make Ag‐P&C NPs prone to target and penetrate into biofilms, and the self‐aggregated capacity helps Ag‐P&C NPs remain in biofilms for a long time to disrupt bacterial biofilm formation. In addition, biocompatible Ag‐P&C NPs are utilized in three types of bacteria‐infected animal models. They exhibit an excellent performance in killing bacteria, inhibiting plaque biofilms, and ameliorating inflammatory responses. In conclusion, this study offers new insights into antibiotic‐free antibacterial strategies, and exhibits promising application prospects.

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Section: Evaluation Of the Bacterial Integrity Disruptionmentioning

confidence: 99%

pH‐Triggered Size‐Tunable Silver Nanoparticles: Targeted Aggregation for Effective Bacterial Infection Therapy

Cheng

Pei

Xie

et al. 2022

Small

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“…Therefore, such surface charge adaptive Ag NPs could penetrate deeply into the biofilms and then kill the bacteria effectively. Zhang et al also reported surface charge adaptive quaternary ammonium salt (QAS)‐based nanoparticles for biofilm treatment (He et al, 2021). The pH‐responsive QAS‐based nanoparticles could not only reduce the inherent toxicity of QAS, but also exhibited effective biofilm penetration and retention.…”

Section: Endogenous Stimuli‐responsive Nanoplatforms For Antibacteria...mentioning

confidence: 99%

“…coli, P. aeruginosa, and S. aureus (J. Chen, Shi, Zhu, et al, 2020) Quaternary ammonium salts Surface charge-convertible micelles S. aureus (He et al, 2021) poly(ethylene glycol) ethyl ether methacrylate-block-poly 2-(diethylamino) ethyl methacrylate (PPEGMA-b-PDEAEMA) (Albayaty et al, 2020). The bactericidal agent itraconazole (ICZ) can be encapsulated into the micelles with high drug load content (12%).…”

Section: Ph-responsive Nanoplatformsmentioning

confidence: 99%

Stimuli‐responsive nanoplatforms for antibacterial applications

Huang

Zou

Wang

et al. 2022

WIREs Nanomed Nanobiotechnol

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“…Moreover, they can be easily adsorbed on solid surfaces, providing them with surface modification properties and antistatic, softening, and hydrophobic effects. Therefore, cationic surfactants play an increasingly important role and are widely used in a variety of fields including home textiles, personal care products, crude oil mining, material synthesis, and asphalt fuel emulsification [ 2 , 3 , 4 , 5 , 6 ]. Especially after the outbreak of the new “coronavirus epidemic” in early 2020, disinfection and sterilization using quaternary ammonium salts has played a key role in ensuring health and safety.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Performance of Double-Chain Quaternary Ammonium Salt Glucosamide Surfactants

et al. 2022

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A series of double-chain quaternary ammonium salt surfactants N-[N′[3-(gluconamide)] propyl-N′-alkyl]propyl-N, N-dimethyl-N-alkyl ammonium bromide (CnDDGPB, where n represents a hydrocarbon chain length of 8, 10, 12, 14 and 16) were successfully synthesized from D (+)-glucose δ-lactone, N, N-dimethyldipropylenetriamine, and bromoalkane using a two-step method consisting of a proamine-ester reaction and postquaternization. Their surface activity, adsorption, and aggregation behavior in aqueous solution were investigated via measurements of dynamic/static surface tension, contact angle, dynamic light scattering, and transmission electron microscopy. An analysis of their application performance in terms of wettability, emulsifying properties, toxicity, and antibacterial properties was conducted. The results show that with increasing the carbon chain length of the CnDDGPB surfactants, their critical micelle concentration (CMC) increased and the pC20 and efficiency in the interface adsorption of the target product gradually decreased. Moreover, the influence of the hydrophobic carbon chain length on the surface of polytetrafluoroethylene (PTFE) was even greater for the wetting effect, reducing the contact angle to 32° within the length range of C8–C14. The results of the contact angle change and the wettability experiments proved that C10DDGPB exhibited the best wettability. The liquid paraffin and soybean oil emulsification ability of CnDDGPB showed an upward trend followed by a downward trend with the growth of the carbon chain, with C12DDGPB exhibiting the best emulsification performance. The Dlong/Dshort ratio was far lower than 1, which indicates mixed-kinetic adsorption. The surfactants formed spherical micelles and showed a unique aggregation behavior in aqueous solution, which showed an increase–decrease–increase trend with the change in concentration. A cell toxicity and acute oral toxicity experiment showed that the CnDDGPB surfactants were less toxic than the commonly used surfactant dodecyldimethylbenzyl ammonium chloride (1227). In addition, at a concentration of 150 ppm, CnDDGPB exhibited the same bacteriostatic effect as 1227 at a concentration of 100 ppm. The results demonstrate that sugar-based amide cationic surfactants are promising as environmentally friendly disinfection products.

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Surface charge-convertible quaternary ammonium salt-based micelles for in vivo infection therapy

Cited by 23 publications

References 42 publications

pH‐Triggered Size‐Tunable Silver Nanoparticles: Targeted Aggregation for Effective Bacterial Infection Therapy

pH‐Triggered Size‐Tunable Silver Nanoparticles: Targeted Aggregation for Effective Bacterial Infection Therapy

Stimuli‐responsive nanoplatforms for antibacterial applications

Synthesis and Performance of Double-Chain Quaternary Ammonium Salt Glucosamide Surfactants

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