Surface chemistry at the nanometer scale influences insulin aggregation

Pandey, Lalit M.; Denmat, Simon Le; Delabouglise, Didier; Brückert, Franz; Pattanayek, Sudip K.; Weidenhaupt, Marianne

doi:10.1016/j.colsurfb.2012.05.022

Cited by 52 publications

(49 citation statements)

References 24 publications

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“…The adsorbed layer often changes its properties over time; this is often associated with a change from a reversible to an irreversible process [168]. The final morphologies of the aggregates formed can be sensitive to the surface chemistry [172,174,178].…”

Section: Surfaces and Interfacesmentioning

confidence: 99%

Factors affecting the physical stability (aggregation) of peptide therapeutics

Zapadka

Becher

Santos³

et al. 2017

Interface Focus.

265

207

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The number of biological therapeutic agents in the clinic and development pipeline has increased dramatically over the last decade and the number will undoubtedly continue to increase in the coming years. Despite this fact, there are considerable challenges in the development, production and formulation of such biologics particularly with respect to their physical stabilities. There are many cases where self-association to form either amorphous aggregates or highly structured fibrillar species limits their use. Here, we review the numerous factors that influence the physical stability of peptides including both intrinsic and external factors, wherever possible illustrating these with examples that are of therapeutic interest. The effects of sequence, concentration, pH, net charge, excipients, chemical degradation and modification, surfaces and interfaces, and impurities are all discussed. In addition, the effects of physical parameters such as pressure, temperature, agitation and lyophilization are described. We provide an overview of the structures of aggregates formed, as well as our current knowledge of the mechanisms for their formation.

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Section: Surfaces and Interfacesmentioning

confidence: 99%

Factors affecting the physical stability (aggregation) of peptide therapeutics

Zapadka

Becher

Santos³

et al. 2017

Interface Focus.

265

207

View full text Add to dashboard Cite

show abstract

“…WCA was measured using sessile drop method as reported previously by our group [29,31]. Contact angle was recorder at three different spots on the same sample using Drop Shape Analyzer-DSA25 (Make: Kruss GmbH-Germany).…”

Section: Water Contact Angle (Wca)mentioning

confidence: 99%

“…It has 8 carbon chain attached to the head group that provides hydrophobicity to the surface. Previously, we have reported effect of TEOS on surface chemistry for modulating protein adsorption and insulin aggregation [29][30][31]. In this work, we have studied the kinetics of TEOS SAM formation on a silica substrate by FTIR, contact angle and AFM.…”

Section: Introductionmentioning

confidence: 98%

Kinetic studies of attachment and re-orientation of octyltriethoxysilane for formation of self-assembled monolayer on a silica substrate

Hasan

Pandey

2016

Materials Science and Engineering: C

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“…Many surfaces modified by polymers or SAMs have been shown to be protein resistant [3][4][5][6][7][8][9][10][11][12][13][14][15]. Surfaces modified with chains of the ethylene oxide [EO] motif, i.e., (CH 2 CH 2 O) n , are the most well studied and understood and, generally, are the surfaces to which other surfaces are ultimately compared.…”

Section: Introductionmentioning

confidence: 99%