Surface Chemistry Influences Implant Biocompatibility

Abstract

Implantable medical devices are increasingly important in the practice of modern medicine. Unfortunately, almost all medical devices suffer to a different extent from adverse reactions, including inflammation, fibrosis, thrombosis and infection. To improve the safety and function of many types of medical implants, a major need exists for development of materials that evoked desired tissue responses. Because implant-associated protein adsorption and conformational changes thereafter have been shown to promote immune reactions, rigorous research efforts have been emphasized on the engineering of surface property (physical and chemical characteristics) to reduce protein adsorption and cell interactions and subsequently improve implant biocompatibility. This brief review is aimed to summarize the past efforts and our recent knowledge about the influence of surface functionality on protein:cell:biomaterial interactions. It is our belief that detailed understandings of bioactivity of surface functionality provide an easy, economic, and specific approach for the future rational design of implantable medical devices with desired tissue reactivity and, hopefully, wound healing capability.

Investigation of the deposition and thermal behavior of striped phases of unsymmetric disulfide self-assembled monolayers on Au(111): The case of 11-hydroxyundecyl decyl disulfide

“…[1][2][3][4][5][6][7] Their fundamental properties, like crystal structures, adsorption dynamics, and mechanism are very important both from a pure scientific point of view and due to their implications on the performance of the applications. [1][2][3][4][5][6][7] For realization of many different purposes, like obtaining a hydrophobic surface for instance, use of single component SAMs is sufficient, hence, properties and film formation dynamics/mechanism of such SAMs, which can be formed by using thiols (R-S-H) or symmetric disulfides (R-S-S-R), are well established. 2,4,[8][9][10][11][12][13][14][15] The monolayer presents two different regimes depending on the density.…”

“…3,4,10,[15][16][17][18][19][20][21][22][23] Upon increasing the coverage, the contribution of the interaction between alkyl chains becomes more important and allows the formation of a standing up configuration with the ( √ 3 × √ 3)R30 • structure. 4,20,24,25 For many other applications like controlled protein adsorption 5,6 or polymer growth on a surface, 26 however, utilization of mixed SAMs, a) Author to whom correspondence should be addressed. Electronic mail: danisman@metu.edu.tr which are made up of two or more components, may be necessary.…”

Functionalizable hydrogel microparticles of tunable size and stiffness for soft-tissue filler applications

“…Particles with acute angles, such as triangles, also induce a greater foreign body response than spherical particles [11]. Surface chemistry is also known to impact the in vivo response to the injected materials [12–15]. For example, polyurethane functionalized with zwitterionic or anionic functional groups showed lower in vivo inflammatory reaction than those functionalized with cationic chemistries [16].…”

Translating Biomaterial Properties to Intracellular Signaling

“…Biomaterials research attempts to bridge this gap by understanding cell-material interactions. Review articles covering various cell types interacting with biomaterials [5,[35][36][37], and the effects of various types of biomaterial properties [38][39][40] are available, and these reviews detail how cells behave differently when contacting materials with a variety of properties. However, this information is of limited utility in developing new materials or even doing new things with existing materials because the underlying mechanism behind why the cells behaved a particular way on a particular surface is not understood.…”