Surface Chemistry of Gold Nanoparticles for Bacterial Detection and Antimicrobial Applications

Ge, Pengfei; Zhang, Jun; Ding, Tian; Xianyu, Yunlei

doi:10.1021/acsmaterialslett.2c00923

Cited by 27 publications

(10 citation statements)

References 120 publications

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“…Localized surface plasmon resonance (LSPR) enhances electric field on the surface of metallic particle, hence and the fluorescent properties of dye molecule in close proximity to it [1,2]. It is usually observed that fluorescence lifetime decreased, and fluorescence intensity might either enhanced or quenched [3,4]. Mechanisms of the interactions between LSPR and fluorephores is explained by by equation ( 1), ( 2), (3), (4) and in Fig.…”

Section: Introductionmentioning

confidence: 97%

Study of fluorescence lifetime modification for car lighting by single gold nanoparticle localized surface plasmon

Minh¹

2023

GSC Adv. Res. Rev.

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Interactions between fluorephores and surface plasmon was investigated by a custom-built fluorescence lifetime system. Gold nanoparticle with double-stranded DNA on the surface was utilized to exactly control the distance between fluorephores and the nanoparticle. We calculated surface plasmon-induced changes in the radiative decay rate constant and the quenching rate constant. The results revealed that the distance between the fluorephore and the nanoparticle strongly affected the radiative decay rate and the quenching rate. With an increase in the distance, the radiative decay rate decreased while the quenching rate increased. This suggests that the distance between fluorephores and surface plasmon plays an important role in fluorescence lifetime modification. The results also indicated that the fluorescence lifetime of the fluorephores can be significantly modified by surface plasmon resonance. This indicates that surface plasmon resonance can be used as a tool to control the fluorescence lifetime of fluorephores for sensing applications.

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Section: Introductionmentioning

confidence: 97%

Study of fluorescence lifetime modification for car lighting by single gold nanoparticle localized surface plasmon

Minh¹

2023

GSC Adv. Res. Rev.

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“…Currently, the enzyme-linked immunosorbent assay (ELISA) for bacterial detection is fast and shows good specificity through the specific binding of antibody and antigen . However, the expensive materials, and usually the need to do the modification of the antibody, result in a more complicated operation procedure, which greatly limits its application. , For multiple bacterial detection, polymerase chain reaction (PCR) technology is commonly used in clinical practice to identify bacteria cultured in culture media . By PCR, the bacterial DNA in the culture media can be amplified, and then the bacterial species can be determined by analyzing the size and sequence of the amplification products .…”

Section: Introductionmentioning

confidence: 99%

Amoxicillin-Induced Purine Molecules Were Used as Bacterial Markers for SERS Detection and Recognition

Hong,

Meng,

Han

et al. 2024

J. Phys. Chem. C

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The amalgamation of surface-enhanced Raman spectroscopy (SERS) and machine learning (ML) presents a discerning capability to differentiate among a diverse spectrum of bacterial strains. However, addressing the challenge of achieving expeditious and robust bacterial detection remains a prominent focal point. This study delineates a comprehensive bacterial classification and identification methodology grounded in the amoxicillin response, which effectively categorizes bacteria utilizing SERS and ML within a time frame of less than 20 min. The bacterial specimens are subjected to pharmacological stimulation, inducing the release of purine molecules that are integral to metabolic processes. Capitalizing on the preferential entry of these molecules into SERS hot spots over the bacteria themselves facilitates the consistent acquisition of stable SERS signals. Experimental evidence demonstrates that the interaction of S. aureus, E. coli, S. epidermidis, C. albicans, and K. pneumoniae with amoxicillin contributes to an enhancement in the stability and signal intensity of bacterial SERS. Utilizing a random forest (RF) model on pure bacterial samples yields an exemplary classification accuracy of 99%. Furthermore, the application of three distinct models, support vector machine (SVM), RF, and CNN-LSTM-Attention (CLA) in the analysis of clinical samples culminates in final classification accuracies of 92%, 87%, and 96%, respectively. This approach establishes a rapid, straightforward, and stable classification methodology for SERS-based bacterial detection, demonstrating significant potential for clinical diagnostic applications.

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“…In recent years, the rapid advancements in nanotechnology have presented a promising avenue for combating MDR bacteria and modulating inflammation. [12][13][14][15][16][17][18] However, there has been a notable scarcity of successful nano-antibacterial drugs specifically designed to address these challenges, with limited mentions of their clinical application. Moreover, two key shortcomings have hindered the practical implementation of these nanoantibacterial drugs: 1) The extended circulation and metabolism challenges associated with nanomaterials have raised persistent safety concerns.…”

Section: Introductionmentioning

confidence: 99%

Aggregation‐Induced Emission Photosensitizer‐Armored Magnetic Nanoparticles for Sepsis Treatment: Combating Multidrug‐Resistant Bacteria and Alleviating Inflammation

Wang,

Chen,

Song

et al. 2023

Adv Funct Materials

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Sepsis, a life‐threatening condition stemming from an uncontrolled host immune response to bacterial infections, continues to impose a significant global burden with high morbidity and mortality. Addressing the challenges posed by antimicrobial resistance and uncontrollable inflammation remains a challenge in sepsis treatment. Moreover, traditional antibacterial materials have low bacterial trapping efficiency and inevitable prolonged circulation within the bloodstream, resulting in suboptimal antibacterial effects, metabolic complications, and undesirable side effects. In this study, an innovative solution is introduced through the development of Fe3O4@SH@TBTCP‐PMB, an aggregation‐induced emission (AIE) photosensitizer (PS)‐armored magnetic nanoparticles (NPs). It has high reactive oxygen species (ROS) generation efficiency and an exceptional ability to capture Gram‐positive bacteria with over 80% enrichment efficiency within just 1 h, even at low bacterial concentrations. Under white light illumination, 100 µg mL−1 of Fe3O4@SH@TBTCP‐PMB effectively eliminated more than 99.9% of methicillin‐resistant Staphylococcus aureus (MRSA). Furthermore, its magnetic separation properties efficiently prevent systemic blood circulation and associated side effects. Most importantly, Fe3O4@SH@TBTCP‐PMB demonstrates superior anti‐inflammatory effects by regulating cytokines, reducing adhesion molecule expression, and managing oxidative stress levels. This multifunctional approach significantly enhances sepsis survival rates, offering a promising strategy for combating multidrug‐resistant (MDR) bacterial infections in sepsis patients while addressing inflammation‐related complications.

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Surface Chemistry of Gold Nanoparticles for Bacterial Detection and Antimicrobial Applications

Cited by 27 publications

References 120 publications

Study of fluorescence lifetime modification for car lighting by single gold nanoparticle localized surface plasmon

Study of fluorescence lifetime modification for car lighting by single gold nanoparticle localized surface plasmon

Amoxicillin-Induced Purine Molecules Were Used as Bacterial Markers for SERS Detection and Recognition

Aggregation‐Induced Emission Photosensitizer‐Armored Magnetic Nanoparticles for Sepsis Treatment: Combating Multidrug‐Resistant Bacteria and Alleviating Inflammation

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