2011
DOI: 10.1016/j.colsurfb.2011.05.047
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Surface chemistry of lipid raft and amyloid Aβ (1-40) Langmuir monolayer

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Cited by 38 publications
(33 citation statements)
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“…21,22,27,3033 Although this system is powerful in providing the molecular detail, Langmuir monolayers of dipalmitoylphosphatidylcholine (DPPC) are frequently used models of eukaryotic cell membranes. Langmuir monolayers have been used previously for a variety of studies, detailing interactions of lipids with cholesterol, 34 phospholipids, fatty acids, 35 proteins, 36,37 and drugs. 3841 By measuring the surface pressure of a phospholipid monolayer as a function of area per molecule, it is possible to compare a compound’s ability to interact with the phospholipid monolayer and determine if it is affecting the rigidity of the monolayer or the packing of the phospholipids.…”
Section: Introductionmentioning
confidence: 99%
“…21,22,27,3033 Although this system is powerful in providing the molecular detail, Langmuir monolayers of dipalmitoylphosphatidylcholine (DPPC) are frequently used models of eukaryotic cell membranes. Langmuir monolayers have been used previously for a variety of studies, detailing interactions of lipids with cholesterol, 34 phospholipids, fatty acids, 35 proteins, 36,37 and drugs. 3841 By measuring the surface pressure of a phospholipid monolayer as a function of area per molecule, it is possible to compare a compound’s ability to interact with the phospholipid monolayer and determine if it is affecting the rigidity of the monolayer or the packing of the phospholipids.…”
Section: Introductionmentioning
confidence: 99%
“…Membranes also contain spatial domains that can be based on lipids [e.g. lipid rafts (Eisenberg et al, 2011;Thakur et al, 2011)] or heterogeneous [e.g. protein corrals (Corbett-Nelson et al, 2006;Leitner et al, 2000;Poudel et al, 2011;Sachs, 2010)].…”
Section: Modulation Of Mechanosensors By the Local Environmentmentioning
confidence: 99%
“…[99][100][101] Basically, the setup consists of a lipid monolayer reconstituted at the air-water interface. [99][100][101] Basically, the setup consists of a lipid monolayer reconstituted at the air-water interface.…”
Section: Key Experiment: the Langmuir Monolayer As A Universal Tool Fmentioning
confidence: 99%
“…This deposition induces an immediate increase in surface pressure followed by a rapid stabilization (Fig. [99][100][101]105 After evaporation of the solvent (usually within 2 min), the protein is injected in the aqueous phase (which can be either pure water or a buffer); the kinetics of protein insertion within the monolayer are followed by real-time measurements of surface pressure.…”
Section: Key Experiment: the Langmuir Monolayer As A Universal Tool Fmentioning
confidence: 99%