Surface Coatings for Rotary Ventricular Assist Devices: A Systematic Review

Zhang, Meili; Tansley, Geoffrey D; Dargusch, Matthew; Pauls, Jo P.

doi:10.1097/mat.0000000000001534

Cited by 6 publications

(4 citation statements)

References 61 publications

(148 reference statements)

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“…The adhesion and aggregation of platelets on the surface of materials can also activate platelets and lead to coagulation. Better blood contact materials (such as vascular catheters) must not only inhibit the adsorption of non-speci c proteins in the blood and lower hemolysis rates but also effectively inhibit platelet adhesion, aggregation, and activation (52,55,56). There was no difference in the amount of platelet deposition adhered to the inner surface of the PTFE-SiO 2 and PTFE-IC@dMSNs catheter, but it was signi cantly reduced compared to the PTFE catheter.…”

Section: In Vitro Blood Compatibilitymentioning

confidence: 99%

Study on PTFE Superhydrophobic Coating Modified by IC@dMSNs and its Enhanced Antibacterial Effect

Zhang¹,

Zhu

et al. 2023

Preprint

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Objective: Vascular catheter-related infections and thrombosis are common and may lead to serious complications after catheterization. Reducing the incidence of such infections has become a significant challenge. This study aims to develop a super hydrophobic nanocomposite drug-loaded vascular catheter that can effectively resist bacterial infections and blood coagulation. Methods: In this study, a SiO2 nanocoated PTFE (Polytetrafluoroethylene) catheter (PTFE-SiO2) was prepared and further optimized to prepare a SiO2 nanocoated PTFE catheter loaded with imipenem/cilastatin sodium (PTFE-IC@dMSNs). The catheters were characterized for performance, cell compatibility, anticoagulant performance, in vitro and in vivo antibacterial effect and biological safety. Result: PTFE-IC@dMSNs catheter has efficient drug loading performance and drug release rate and has good cell compatibility and anticoagulant effect in vitro. Compared with the PTFE-SiO2 catheter, the inhibition ring of the PTFE-IC@dMSNs catheter against Escherichia coli increased from 3.985 mm2 to 4.561 mm2, and the antibacterial rate increased from about 50.8% to 56.9%, with significant difference (p<0.05). The antibacterial zone against Staphylococcus aureus increased from 8.633 mm2 to 11.735 mm2, and the antibacterial rate increased from approximately 83.5% to 89.3%, showing a significant difference (p<0.05). PTFE-IC@dMSNs catheter also has good biocompatibility in vivo. Conclusion: Compared with PTFE, PTFE-SiO2 and PTFE-IC@dMSNs catheters have good characterization performance, cell compatibility, and anticoagulant properties. PTFE SiO2 and PTFE-IC@dMSNs catheters have good antibacterial performance and tissue safety against E. coli and S. aureus. Relatively, PTFE-SiO2 and PTFE-IC@dMSNs catheter has better antibacterial properties and histocompatibility and has potential application prospects in anti-bacterial catheter development and anticoagulation.

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Section: In Vitro Blood Compatibilitymentioning

confidence: 99%

Study on PTFE Superhydrophobic Coating Modified by IC@dMSNs and its Enhanced Antibacterial Effect

Zhang¹,

Zhu

et al. 2023

Preprint

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“…It is estimated that there are more than 5.8 million heart failure patients in the USA with a 30-day mortality rate of 11%, a hospitalization rate of ~25%, and a 5-year survival time worse than most cancers [3]. Aside from that, there are 15 million patients in Europe who account for 45% of deaths [4].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Testing of Stereolithography (SLA)-Manufactured Haemocompatible Photopolymers for Blood Pump

Major,

Gawlikowski,

Surmiak

et al. 2023

Applied Sciences

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A major medical problem of state-of-the-art heart ventricular assist devices (LVADs) is device-induced thrombus formation due to inadequate blood-flow dynamics generated by the blood pump rotor. The latter is a highly complex device, with difficulties during conventional manufacturing through milling or casting. Therefore, the additive manufacturing technology relying on stereo-lithography (SLA) capable of producing parts of significantly increased freedom for a blood-flow-compatible, thrombus-risk-free design was chosen as novel and flexible technology for that type of application. However, as yet state-of-the-art SLA is not suitable to produce fully safe blood-contacting devices. Therefore, the present experiment covered chemical, mechanical, rheological, tribological, and complex biocompatibility characterization in accordance with i.a. ISO 10993 standards, including hemolysis and an acute thrombogenicity blood test on fresh animal blood (both as innovative laboratory tests to avoid animal usage in preclinical studies) with a special focus on testing demonstrators of miniaturized blood pump rotors. The conducted tests indicated acceptable biocompatibility of the material and a slight improvement in biocompatibility with surface modification. Additionally, a high biocompatibility of the tested materials was confirmed. Based on studies and simulations, stereolithography (SLA) as an additive manufacturing technology with significantly increased freedom for a blood-flow-compatible, thrombus-risk-free design was chosen as a novel and flexible technology basis in the 4DbloodROT project to enable future manufacturing of rotors with exceptional biomimetic complexity.

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“…However, there are few studies addressing wear-resistant coatings for VADs via preparation at VADs-friendly temperature based on our recent systematic review on coatings for VADs. 9 Diamond-like carbon (DLC) films, with excellent wear resistance, good mechanical properties, haemocompatibility, and biocompatibility, [10][11][12] can be desirable for surface modification of Ti6Al4V used for VADs manufacturing. Łępicka et al 13 analyzed the coefficient of friction time series of non-coated and DLC-coated Ti6Al4V acquired during tribological tests, and confirmed that the DLC films could reduce wear of Ti6Al4V alloys.…”

Section: Introductionmentioning

confidence: 99%

“…Taken together, it is of high practical value to develop wear‐resistant coatings for VADs under the magnets‐tolerable temperatures. However, there are few studies addressing wear‐resistant coatings for VADs via preparation at VADs‐friendly temperature based on our recent systematic review on coatings for VADs 9 …”

Section: Introductionmentioning

confidence: 99%

Diamond‐like carbon films prepared by a low temperature periodic process for application in ventricular assist devices

et al. 2022

Self Cite

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Due to the poor tribological properties of titanium (Ti) and its alloy Ti6Al4V (commonly used for ventricular assist devices manufacturing), diamond‐like carbon (DLC) films with excellent anti‐wear properties are pursued to improve the wear resistance of Ti and its alloys. Considering the effect of temperature on magnets inside pump impellers and workpiece deformation, DLC films are preferred to be prepared under low temperature. In this study, DLC films were prepared on Ti6Al4V alloys by periodic and continuous processes, and the corresponding maximum deposition temperature was 85 and 154°C, respectively. The periodic DLC films exhibited the feature of columnar structure, and the surface hillocks were less uniform than that of continuous DLC films. The periodic DLC films possessed more sp3‐bonded structures, and the accessorial sp3‐bonding mainly existed in the form of CH. Compared to continuous DLC films, the periodic DLC films had lower residual stress and better adhesion with Ti6Al4V substrates. Both DLC films could effectively reduce the friction coefficient and wear rate of Ti6Al4V alloys both in air and fetal bovine serum (FBS), and the periodic DLC films exhibited superior anti‐wear properties to that of continuous DLC films in FBS. Haemocompatibility evaluation revealed that both DLC films presented similar levels of more human platelet adhesion and activation as compared with that of bare Ti6Al4V. However, both DLC films significantly prolonged plasma clotting time in comparison to bare Ti6Al4V. This study demonstrates the potential of low‐temperature DLC films as wear‐resistant surface modification for VADs.

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Surface Coatings for Rotary Ventricular Assist Devices: A Systematic Review

Cited by 6 publications

References 61 publications

Study on PTFE Superhydrophobic Coating Modified by IC@dMSNs and its Enhanced Antibacterial Effect

Study on PTFE Superhydrophobic Coating Modified by IC@dMSNs and its Enhanced Antibacterial Effect

In Vitro and In Vivo Testing of Stereolithography (SLA)-Manufactured Haemocompatible Photopolymers for Blood Pump

Diamond‐like carbon films prepared by a low temperature periodic process for application in ventricular assist devices

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