Surface design and preparation of multi-functional magnetic nanoparticles for cancer cell targeting, therapy, and imaging

Abstract

Multi-functional magnetic nanoparticles for targeted anticancer drug delivery and efficient MR imaging detection in theranostics.

Surface Membrane Coating as a Versatile Platform for Modifying Antitumor Nanoparticles

“…Qu and her colleagues prepared polyamidoamine (PAMAM) multifunctional copolymer coatings on SPIONs, and the obtained MNPs-DOX exhibited excellent biocompatibility, biodegradability, colloidal stability, and long-term cycling, promoting SPIONs feasibility and effectiveness of translation to clinical therapeutic diagnosis. 110 Zwitterionic Polymers. The application of multifunctional, stimulus-responsive stealth zwitterionic polymers coat- ing will be more prominent and worth exploring because of better/excellent biodegradability, controllable hydrophilicity, good antifouling performance, negligible immunotoxicity, and additional chemical functionality.…”

“…Efficient clinical translation of superparamagnetic iron oxide nanoparticles (SPIONs) in MRI and theranostic diagnosis is hindered by their susceptibility to oxidative aggregation, premature drug release, and lack of specific tumor targeting. Qu and her colleagues prepared polyamidoamine (PAMAM) multifunctional copolymer coatings on SPIONs, and the obtained MNPs-DOX exhibited excellent biocompatibility, biodegradability, colloidal stability, and long-term cycling, promoting SPIONs feasibility and effectiveness of translation to clinical therapeutic diagnosis …”

Synthesis of Bis (Benzoyl Acetone Ethylene Diimine) Schiff Base Complex of Nickel (II) Supported on Magnetite Silica Nano-Particles (Fe3O4@Sio2/Schiff-Base Of Ni (II)) and Using it as an Efficient Catalyst for Green Synthesis of 1-Amidoalkyl-2-Naphthol.

“…In the fourth part, the temperature reached 70 ° C, but the amount of catalyst was not reduced, which also reduced the e ciency (Table 2, entry 4). Amidoalkyle naphthols can be prepared with almost any aldehyde but, electron donor groups such as CH 3 , OH, etc, on the aldehyde are not suitable because the transition state of amido alkyl-2-naphthol is unstable and the production of product has a low e ciency (Table 2, entry 5,6,9). The electron withdrawing groups on the aldehyde such as NO 2 , Cl is very suitable for this process because it makes the higher e ciency for production (Table 2, entry 7, 8).…”

“…In recent years, the synthesis of Magnetic nanoparticles (MNPs) have advantages and make higher interest and attention because of their properties and potential applications in different elds [1] for example catalyst [2], drug delivery systems [3,4], and cancer treatments [5]. Magnetite iron oxide nanoparticles especially Fe 3 O 4 are very well known for researchers because of their special physical properties including low toxicity [6], high surface area [7,8] easy preparation, and easy recycling with a simple external magnet [9].…”

Disulfide Cross-Linked Poly(Methacrylic Acid) Iron Oxide Nanoparticles for Efficiently Selective Adsorption of Pb(II) from Aqueous Solutions

“…According to an already published procedure, 60 mL of deionized water was used to dissolve FeCl 3 ·6H 2 O (2.7 g, 15.5 mmol) and FeCl 2 ·4H 2 O (1.0 g, 15.2 mmol). The synthesis procedure was under N 2 protection, and ammonia solution was added into the mixture with vigorous mechanical stirring at 80 °C for half an hour.…”