Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy

Kang, Thomas H.‐K.; Li, Fangyuan; Baik, Seungmin; Shao, Wei; Ling, Daishun; Hyeon, Taeghwan

doi:10.1016/j.biomaterials.2017.05.013

Cited by 261 publications

(138 citation statements)

References 216 publications

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“…Moreover, they can bind to antibodies, nucleotides, proteins, enzymes, or drugs [38]. Therefore, the surface of these particles could be modified creating new atomic layers of inorganic metallic (e.g., gold), organic polymer, or oxide surfaces (e.g., silica or alumina) [6,17,25,36,53]. Assemblies of IOMNPs are also possible, resulting in nanostructures with physical and chemical properties different from those of both individual IOMNPs and their bulk aggregates.…”

Section: Methods Referencesmentioning

confidence: 99%

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

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Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

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Section: Methods Referencesmentioning

confidence: 99%

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

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“…Different from other kinds of strategies, magnetic drug delivery system could effectively deliver cargoes including immune checkpoint inhibitors to specific tumor site under the influence of external magnetic field . Recently, Chiang et al reported magnetic nanoparticles called IO@FuDex3, super‐paramagnetic iron oxide nanoparticles, to combine fucoidan and anti‐PD‐L1 for enhancing tumor‐localized immunotherapy .…”

Section: Biomaterial‐based Strategy Integrated With Icb For Synergistmentioning

confidence: 99%

Toward Biomaterials for Enhancing Immune Checkpoint Blockade Therapy

Fan

Chen

Wang

et al. 2018

Adv Funct Materials

107

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Despite the remarkable progress in immune checkpoint blockade (ICB) therapy for cancer treatment, low objective response and immune‐related side effects (immune‐related adverse events, irAEs) limit the further development of ICBs. To address these challenges and enhance the efficiency of cancer immunotherapy, the emerging interest has focused on manipulating biomaterials to form innovational drug delivery systems that are necessary to effectively deliver immune checkpoint inhibitors. Such biomaterial‐based strategies can improve accumulation, control release, and enhance retention of checkpoint inhibitors within target locations while simultaneously reducing drug exposure for off‐target tissues, thereby optimizing both the efficacy and safety. In addition, with the assistance of biomaterials, combinations of ICB and conventional treatment strategies including chemotherapy, radiotherapy, and phototherapy are designed to further enhance the response rate of ICB. This review focuses on the latest reports on engineering biomaterials to improve the antitumor efficiency of ICB, with stress on antibody‐, gene‐, and trap protein–based immune checkpoint blockade strategies and their combinations with conventional therapies. Challenges and future trends in engineering biomaterials to modulate immune checkpoint therapy are discussed.

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“…The goal‐directed delivery of PMs largely relies on several targeting materials. Among various targeting materials, magnetic nanoparticles (MNPs) are attractive owing to its strong magnetism, good chemical stability, high biocompatibility, low toxicity and mature preparation process . The magnetic response of MNPs can be utilized as an effective impulse of MNPs‐loaded materials toward the established site with the help of a magnetism‐controlling device.…”

Section: Targeting and Stimuli‐responsive Behaviors Of Pmsmentioning

confidence: 99%

Sonochemistry‐Assembled Stimuli‐Responsive Polymer Microcapsules for Drug Delivery

Wang

et al. 2018

Adv Healthcare Materials

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Stimuli-responsive polymer microcapsules (PMs) fabricated by the sonochemical method have emerged for developing useful drug delivery systems, and the latest developments are mainly focusing on the synthetic strategies and properties such as structure, size, stability, loading capacity, drug delivery, and release. There, the primary attribution of sonochemistry is to offer a simple and practical approach for the preparation of PMs. Structure, size, stability, and properties of PMs are designed mainly according to synthetic materials, implementation schemes, or specific demands. Numerous functionalities of PMs based on different stimuli are demonstrated: targeting motion in a magnetic field or adhering to the living cells with sensitive sites through molecular recognition, and stimuli-triggered release including enzymatic catalysis, chemical reaction as well as physical or mechanical process. The current review discusses the basic principles and mechanisms of stimuli effects, and describes the progress in the application such as targeted drug systems and controlled drug systems, and also gives an outlook on the future challenges and opportunities for drug delivery and theranostics.

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Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy

Cited by 261 publications

References 216 publications

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Toward Biomaterials for Enhancing Immune Checkpoint Blockade Therapy

Sonochemistry‐Assembled Stimuli‐Responsive Polymer Microcapsules for Drug Delivery

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