Surface Desorption Dielectric-Barrier Discharge Ionization Mass Spectrometry

Zou, Hong; Jiang, Jie; Li, Na; Li, Ming; Wang, Yingying; He, Jing; You, Hong

doi:10.1021/acs.analchem.7b00323

Cited by 19 publications

(9 citation statements)

References 36 publications

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“…The SDDBDI was described in detail elsewhere . The reactive SDDBDI was achieved by adding a reagent into the discharge gas before the plasma ions were directed to the cover slip surface deposited with another reagent.…”

Section: Methodsmentioning

confidence: 99%

“…Also, a modified LTP probe with reactants doping into the discharge gas is developed to produce reagent ions that can undergo ion/molecule reactions in the ambient environment with an analyte at condensed phase on a surface . Recently, a novel plasma‐based method named surface desorption dielectric‐barrier discharge ionization (SDDBDI) is developed in our laboratory . Applying a high voltage to a nanotip placed in front of the MS inlet with an insulating dielectric in between induces a plasma plume between the nanotip and the MS inlet.…”

Section: Introductionmentioning

confidence: 99%

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Intermediate detection in real time using reactive surface desorption dielectric‐barrier discharge ionization mass spectrometry

Zou

et al. 2018

J Mass Spectrom

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Reactive intermediates play key roles for reaction mechanism elucidation. A suitable tool for identifying the key intermediates is crucial and highly desirable. In this study, surface desorption dielectric-barrier discharge ionization (reactive SDDBDI) was developed for characterization of the reactive intermediates. In reactive SDDBDI, the plasma is doped with a reagent before the plasma ions are directed at a cover slip surface bearing another analyte. Different from SDDBDI, reactive SDDBDI can be used both as an ambient ionization source and as a means to produce reagent ions for ambient ion/molecule reactions. The online derivation of 4-aminophenol with trifluoroacetic anhydride demonstrated that reactive SDDBDI can be used for chemical analysis where improved specificity or sensitivity is required. The utility of this approach for real-time detection of reactive intermediate was demonstrated by the Schiff-base and Eberlin reactions. The formed intermediates and products could be readily detected and identified by tandem mass spectrometry. These results indicate that reactive SDDBDI can be used to generate reagent ions that undergo ion/molecule reactions in the open air with an analyte at condensed phase on a surface. Reactive SDDBDI has high-efficiency ion transmission and high MS sensitivity. It is thus a potential tool to perform ambient ion/molecule reactions and detect reactive intermediates.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intermediate detection in real time using reactive surface desorption dielectric‐barrier discharge ionization mass spectrometry

Zou

et al. 2018

J Mass Spectrom

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“…A detailed description of SDDBDI is given elsewhere. 25 All of the operation parameters for He-SDDBDI and Ar-SDDBDI were the same except for the discharge gases applied. Briefly, a nanotip was used as the discharge electrode and the MS inlet was the ground electrode (Figure 1a).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…A detailed description of SDDBDI is given elsewhere . All of the operation parameters for He-SDDBDI and Ar-SDDBDI were the same except for the discharge gases applied.…”

Section: Experimental Sectionmentioning

confidence: 99%

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Doped Argon Surface Desorption Dielectric-Barrier Discharge Ionization Mass Spectrometry for Fragile Compounds

Zou

Qiao

et al. 2018

Anal. Chem.

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Argon surface desorption dielectric-barrier discharge ionization (Ar-SDDBDI) in conjunction with dopants was reported for rapid and sensitive determining of fragile compounds. In dopant/Ar-SDDBDI, analytes are ionized primarily through proton transfer with dopant ions, which are formed in Ar plasma. Different from He, dopant/Ar-SDDBDI generates low energetic ions, and therefore, fragmentation is suppressed. It thus significantly simplifies the mass spectra and the assignment of one peak. Dopants ranging from organic solvents to gaseous materials were systematically studied. The application of dopant/Ar-SDDBDI was demonstrated by analysis of multiple compounds, including antibiotics, amino acids, fatty acids, hormones, pharmaceuticals, and peptides. Rapid profiling of chemicals in such complex matrixes including mixtures and drug tablets was also tested. Positive and negative mass spectra with little to no fragmentation for compounds in the pure state and as mixtures were readily achieved. Limits of detection (S/N = 3) were determined to be 0.60 and 0.36 pmol, respectively, for the analysis of l-alanine and metronidazole. Furthermore, the demonstration applications also included imaging of an "H" character under ambient conditions. These results indicate that the technique by combining of Ar-SDDBDI with dopants exhibits high sensitivity, high spatial resolution, and a very low degree of fragmentation, which render it a potential tool for fragile compound analysis in mass spectrometry imaging.

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Liquid chromatography‐dielectric barrier discharge ionization mass spectrometry for the analysis of neutral lipids of archaeological interest

Bouza

García-Martínez

Gilbert-López

et al. 2022

J of Separation Science

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Dielectric barrier discharge ionization has gained attention in the last few years due to its versatility and the vast array of molecules that can be ionized. In this study, we report on the assessment of liquid chromatography coupled to dielectric barrier discharge ionization with mass spectrometry for neutral lipid analysis. A set of different neutral lipid subclasses (triacylglycerides, diacylglycerides, and sterols) were selected for the study. The main species detected from our ionization source were [M‐H2O+H]+, [M+H]+ or [M‐R‐H2O+H]+, attributed to sterol dehydration, protonation or the fragmentation of an acyl chain accompanied by a water loss of the glycerolipids, respectively. In terms of sensitivity, the dielectric barrier discharge displayed overall improved abundances and comparable or better limits of quantitation than atmospheric pressure chemical ionization for both acylglycerols and sterols. As a case study, different archaeological samples with variable content in neutral lipids, particularly triacylglycerides, were studied. The identification was carried out by combining accurate mass and the tentative formula associated with the exact mass, retention time matching with standards, and additional structural information from in‐source fragmentation. The high degree of unsaturation and the presence of sterols revealed the potential vegetal origin of the material stored in the analyzed samples.

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Surface Desorption Dielectric-Barrier Discharge Ionization Mass Spectrometry

Cited by 19 publications

References 36 publications

Intermediate detection in real time using reactive surface desorption dielectric‐barrier discharge ionization mass spectrometry

Intermediate detection in real time using reactive surface desorption dielectric‐barrier discharge ionization mass spectrometry

Doped Argon Surface Desorption Dielectric-Barrier Discharge Ionization Mass Spectrometry for Fragile Compounds

Liquid chromatography‐dielectric barrier discharge ionization mass spectrometry for the analysis of neutral lipids of archaeological interest

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