Surface development of molecularly imprinted polymer films to enhance sensing signals

A novel strategy to improve the sensitivity of antibiotics determination based on bioelectrocatalysis at molecularly imprinted polymer film electrodes

“…Taking the LOD as an example, the KA-PPY MIP film system based on bioelectrocatalysis was superior to ordinary MIP film systems without using nanomaterials (Karimian et al, 2013;Liu et al, 2011;Wang et al, 2014), and it was comparable to or at the same order of magnitude as those with nanoparticles (Han et al, 2014;Xue et al, 2014;Yu et al, 2014). Some MIP systems with incorporated gold nanoparticles and/or carbon nanotubes demonstrated extremely high sensitivity (Rezaei et al, 2014a(Rezaei et al, , 2014b, possibly because the high effective surface area of electrodes led to the increase in the amount of recognition sites in the MIP films, and the excellent conductivity of the systems resulted in better electron transfer of the probe with the underlying electrodes (Irshad et al, 2013;Sharma et al, 2013). We thus expect that the combination of our bioelectrocatalysis strategy with nanomaterials, especially gold nanoparticles and carbon nanotubes, might provide further improved analytical performance.…”

“…Thus, the combination of MIP with electrochemical measurement has become a promising method for the detection of various substances (Alegret, 2002;Blanco-López et al, 2004;Piletsky and Turner, 2002;Suryanarayanan et al, 2010). Particularly, the electrochemical polymerization of MIP films on the surface of electrodes shows remarkable merits, such as the simple and tunable preparation procedure and the formation of very thin films that are beneficial to rapid response (Sharma et al, 2012(Sharma et al, , 2013.…”

Molecular imprinting: perspectives and applications

“…[509][510][511][512] The characteristic feature of MIP-based sensors is that the MIPs have both recognition and transduction properties, that is, the MIPs as recognition elements can specifically bind target analytes and as transduction elements can generate output signals for detection. The characteristic feature and basic construction of MIP-based sensors are schematically illustrated in Fig.…”

Chemical sensors based on polymer composites with carbon nanotubes and graphene: the role of the polymer

“…The advantages of MIPs lie in the rapid and low-cost synthesis and the possibility of tuning the selectivity by means of the appropriate selection of templates in the imprinting process. [215][216][217][218] In addition, the use of a thin layer of MIP on the electrode surface as a recognition element of the sensor greatly improves the electrode selectivity.…”