Surface dialysis after experimental brain injury: modification of edema fluid flow in the rat model

Shulyakov, Alexander V.; Benour, Mahmoud; Bigio, Marc R. Del

doi:10.3171/jns/2008/109/10/0670

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…24 Ten minutes later, anesthetized rats were killed by exsanguination; ice-cold phosphate-buffered saline followed by 100 ml of 10% formalin was then perfused through the heart.…”

Section: Evans Blue Injectionsmentioning

confidence: 99%

Intracranial biomechanics following cortical contusion in live rats

Alfasi¹,

Shulyakov

Bigio

2013

JNS

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Object. The goal of this study was to examine the mechanical properties of living rat intracranial contents and corresponding brain structural alterations following parietal cerebral cortex contusion.Methods. After being anesthetized, young adult rats were subjected to parietal craniotomy followed by cortical contusion using a calibrated weight-drop method. Magnetic resonance imaging was used to visualize the contusion. At the site of contusion, instrumented force-controlled indentation was performed 2 hours to 21 days later on the intact dural surface. The force-deformation (stress-strain) relationship was used to calculate elastic (indentation modulus) and strain changes over time, and constant hold or cyclic stress was used to evaluate viscoelastic deformation. These measurements were followed by histological studies.Results. At contusion sites, the indentation modulus was significantly decreased at 1-3 days and tended to be above control values at 21 days. Multicycle indentation showed that the brain tended to accumulate more strain (an indicator of viscosity) by 1 day after the contusion. Imaging and histological studies showed local edema and hemorrhage at 6 hours to 3 days and accumulation of reactive astrocytes, which began at 3 days and was pronounced by 21 days.Conclusions. The viscoelastic properties of living rat brain change following contusion. Initially, edema and tissue necrosis occur, and the brain becomes less elastic and less viscous. Later, along with undergoing reactive astroglial changes, the brain tends to become stiffer than normal. These quantitative data, which are related to the physical changes in the brain following trauma and which reflect subjective impressions upon palpation, will be useful for understanding emerging diagnostic tools such as magnetic resonance elastography.

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“…24 Ten minutes later, anesthetized rats were killed by exsanguination; ice-cold phosphate-buffered saline followed by 100 ml of 10% formalin was then perfused through the heart.…”

Section: Evans Blue Injectionsmentioning

confidence: 99%

Intracranial biomechanics following cortical contusion in live rats

Alfasi¹,

Shulyakov

Bigio

2013

JNS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Shulyakov et al [42 ] report their laboratory work (in rats) to study this possibility: after cryogenic brain injury and decompressive craniectomy, a dialysis membrane placed on the damaged brain surface for 2 h resulted in significantly decreased cerebrospinal fluid (CSF) pressure in comparison with craniotomy alone or sham dialysis. An osmotic cell with a semipermeable dialysis membrane was perfused with dextran 15% solution for several hours; water content, albumin spread, and brain temperature were measured.…”

Section: Neurologicmentioning

confidence: 97%

Critical care organ support: a focus on extracorporeal systems

McCunn

Reed

2009

Current Opinion in Critical Care

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“…The authors postulate that edema luid moves into the osmotic cell rather than spreading through the uninjured brain. Long-term experiments will be needed to prove that this combination therapy is effective [31].…”

Section: Martin Marsala Et Almentioning

confidence: 99%

The turing machine theory for some spinal cord and brain condition, A toxicological - antidotic depurative approach

Luisetto¹,

Ahmadabadi²,

Rafa³

et al. 2019

J Neurosci Neurol Disord

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Aim of this work is to produce a general theory related an new depurative strategy to be devalued for reduce or delay some spinal cord and brain degenerative and infl ammatory chronic disease or acute traumatic condition. It is used and informatics approach in order to set correct the problem and the process. Scope of this project is to submit to the researcher a new therapeutic strategy (under a depurative-toxicological-pharmacological) in this complex kind of disease. A Turing machine theory say us a method to TRASLATE the need of a strategy in a practical hypotesys of work. A global conceptual map can help in this fi eld.

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Surface dialysis after experimental brain injury: modification of edema fluid flow in the rat model

Cited by 5 publications

References 35 publications

Intracranial biomechanics following cortical contusion in live rats

Intracranial biomechanics following cortical contusion in live rats

Critical care organ support: a focus on extracorporeal systems

The turing machine theory for some spinal cord and brain condition, A toxicological - antidotic depurative approach

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