Surface-engineered liposomal particles of calcium ascorbate with fenugreek galactomannan enhanced the oral bioavailability of ascorbic acid: a randomized, double-blinded, 3-sequence, crossover study

Abstract

A green process to modulate the surface properties of liposome was reported using fenugreek galactomannan hydrogel and successfully applied to vitamin C with significant enhancement in human oral bioavailability.

Enhanced Bioavailability and Pharmacokinetics of a Natural Self-Emulsifying Reversible Hybrid-Hydrogel System of Quercetin: A Randomized Double-Blinded Comparative Crossover Study

“…A self-nanoemulsifying drug delivery system was reported to enhance the bioavailability of quercetin in rats . Thus, micellar, liposomal, and self-emulsifying nanodelivery systems employing synthetic materials could be a plausible option to improve bioavailability, in spite of their disadvantages such as poor thermodynamic stability, poor stability under gastrointestinal conditions, low drug loading ability, liquid state, and excessive use of synthetic emulsifiers. , …”

“…stability, poor stability under gastrointestinal conditions, low drug loading ability, liquid state, and excessive use of synthetic emulsifiers. 27,28 The current study was aimed at the investigation of the morphological characteristics, solubility, in vitro release properties, and human pharmacokinetics of a novel food-grade hybrid-hydrogel formulation of quercetin (FQ-35), in comparison with unformulated quercetin (UQ). The formulation was prepared by a gel-phase dispersion of quercetin micelles into fenugreek galactomannan hydrogel (referred to as "Hybrid-FenuMAT") and further dehydration under vacuum to powder.…”

“…Hybrid-hydrogels have been identified as a promising approach for oral drug delivery systems since they can enhance the in vivo stability and release properties of drugs . High molecular weight, extensive hydration to stable softgel, mucoadhesive character, high emulsifying capacity, and amphiphilic nature to bind both oil and water make fenugreek galactomannan (FenuMAT) to behave like a cross-linked polymer for drug delivery. ,, The microstructure of FG allows the encapsulation of hydrophobic molecules in its conformationally directed hydrophobic pockets created in the swollen network. This is clear from the observed high encapsulation efficiency (>95%) of quercetin in FQ-35.…”

“…Recently, hydrogels are emerging as potential candidates for oral delivery . Hybrid-hydrogels incorporated with nano/microstructures like liposome/micelles are intelligent drug delivery systems to enhance not only the therapeutic efficacy but also for the sustained release of the drug molecules. , Recently, we reported a hybrid-hydrogel system for vitamin C and resveratrol with improved stability, solubility, and hence enhanced human bioavailability using fenugreek (Trigonella foenum-graecum) galactomannan (FG) as the hydrogel scaffold. , The formulation was characterized as a food-grade and commercially viable “natural self-emulsifying reversible hybrid-hydrogel” (N’SERH) delivery system. In the present study, we aimed at the investigation of the solubility, particle size analysis, in vitro release profile, stability, and human pharmacokinetics of a N’SERH formulation of quercetin (FQ-35).…”

“… 25 , 26 Recently, we reported a hybrid-hydrogel system for vitamin C and resveratrol with improved stability, solubility, and hence enhanced human bioavailability using fenugreek ( Trigonella foenum-graecum ) galactomannan (FG) as the hydrogel scaffold. 27 , 28 The formulation was characterized as a food-grade and commercially viable “natural self-emulsifying reversible hybrid-hydrogel” (N’SERH) delivery system. In the present study, we aimed at the investigation of the solubility, particle size analysis, in vitro release profile, stability, and human pharmacokinetics of a N’SERH formulation of quercetin (FQ-35).…”