Surface-Engineered Nanoliposomes by Chelating Ligands for Modulating the Neurotoxicity Associated with β-Amyloid Aggregates of Alzheimer’s disease

Mufamadi, Maluta Steven; Choonara, Yahya E.; Kumar, Pradeep; Modi, Girish; Naidoo, Dinesh; Ndesendo, Valence M. K.; Toit, Lisa C. du; Iyuke, Sunny E.; Pillay, Viness

doi:10.1007/s11095-012-0770-0

Cited by 20 publications

(6 citation statements)

References 46 publications

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“…As determined by the 3D geometrical conformation and stabilization via molecular modeling, the addition of CHOL provided the much needed space filling properties to the ternary system wherein the van der Waals space of the molecular complex contributed to matrix stabilization. This change in H‐bonding dominated system to hydrophobically stabilized system was further responsible for the self‐assembly of the complex into nanoliposomes (nanoformation) when hydrated in phosphate buffered saline . Furthering the modeling paradigm of the effect of PEG on nanoformation, Tomar and coworkers discussed how using an amphiphilic PEG can assist in nanostabilization and nanoperformance.…”

Section: Nanoformation and Solvation Properties Of Polymeric Nanosystemsmentioning

confidence: 99%

In silico analytico‐mathematical interpretation of biopolymeric assemblies: Quantification of energy surfaces and molecular attributes via atomistic simulations

Kumar

Choonara

Pillay

2018

Bioengineering & Transla Med

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Static‐lattice atomistic simulations, in vacuum and solvent phase, have been recently employed to quantify the “in vitro—in vivo—in silico” performance‐correlation profile of various drug delivery systems and biomaterial scaffolds. The reactional profile of biopolymers was elucidated by exploring the spatial disposition of the molecular components with respect to the formulation conditions and the final release medium. This manuscript provides a brief overview of recently completed and published studies related to molecular tectonics of: (a) the nanoformation and solvation properties of the surfactant‐emulsified polymeric systems; (b) the formation and chemistry of polyelectrolyte complexes; (c) the effect of a plasticizer and/or drug on the physicomechanical properties of biomedical archetypes; (d) the molecular modeling templates to predict stimuli‐ and environmentally esponsive systems; and (e) the polymer‐mucopeptide complexes and intermacromolecular networks. Furthermore, this report provides a detailed account of the role of molecular mechanics energy relationships toward the interpretation and understanding of the mechanisms that control the formation, fabrication, selection, design, performance, complexation, interaction, stereospecificity, and preference of various biopolymeric systems for biomedical applications.

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Section: Nanoformation and Solvation Properties Of Polymeric Nanosystemsmentioning

confidence: 99%

In silico analytico‐mathematical interpretation of biopolymeric assemblies: Quantification of energy surfaces and molecular attributes via atomistic simulations

Kumar

Choonara

Pillay

2018

Bioengineering & Transla Med

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“…Another interesting study reported that nanoliposomes modified with different chelating ligands such as copper acetate, histidine, zinc acetate and ethylenediaminetetraacetic acid disaggregated and resolubilized Cu-Aβ 1-42 and Zn-Aβ 1-42 aggregates in PC12 neuronal cells. This finding suggests that chelating ligand-bound NPs can protect neuronal cells from Aβ aggregation-induced toxicity [22].…”

Section: Inhibition Of Aβ Aggregationmentioning

confidence: 89%

Application of Nanodiagnostics and Nanotherapy to CNS Diseases

Zhang

Wang

et al. 2018

Nanomedicine (Lond.)

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Alzheimer's disease, Parkinson's disease and stroke are the most common CNS diseases, all characterized by progressive cellular dysfunction and death in specific areas of the nervous system. Therapeutic development for these diseases has lagged behind other disease areas due to difficulties in early diagnosis, long disease courses and drug delivery challenges, not least due to the blood-brain barrier. Over recent decades, nanotechnology has been explored as a potential tool for the diagnosis, treatment and monitoring of CNS diseases. In this review, we describe the application of nanotechnology to common CNS diseases, highlighting disease pathogenesis and the underlying mechanisms and promising functional outcomes that make nanomaterials ideal candidates for early diagnosis and therapy. Moreover, we discuss the limitations of nanotechnology, and possible solutions.

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“…Mufamadi et al developed surface decorated nanoliposomes (NLPs) using different chelating agents viz. ethylenediaminetetraacetic acid (EDTA), histidine residues, copper acetate (CuAc) and zinc acetate (ZnAc) to modulate neurotoxicity associated with Aβ aggregates of AD [113]. The result of their in vitro studies in PC12 neuronal cell line confirmed that the incubation of Cu(II) or Zn(II) with Aβ 1–42 peptide stimulated Aβ aggregation.…”

Section: Nanotechnology Based Theranostics In Admentioning

confidence: 99%

Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective

Ahmad

Akhter

Rizwanullah

et al. 2017

CAR

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Background Alzheimer's disease (AD), a cognitive dysfunction/dementia state amongst the elders is characterized by irreversible neurodegeneration due to varied pathophysiology. Up till now, anti-AD drugs having different pharmacology have been developed and used in clinic. Yet, these medications are not curative and only lowering the AD associated symptoms. Improvement in treatment outcome required drug targeting across the blood-brain barrier (BBB) to the central nervous system (CNS) in optimal therapeutic concentration. Nanotechnology based diagnostic tools, drug carriers and theranostics offer highly sensitive molecular detection, effective drug targeting and their combination. Over the past decade, significant works have been done in this area and we have seen very remarkable outocome in AD therapy. Various nanoparticles from organic and inorganic nanomaterial category have successfully been investigated against AD. Conclusion This paper discussed the role of nanoparticles in early detection of AD, effective drug targeting to brain and theranostic (diagnosis and therapy) approaches in AD’s management.

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Surface-Engineered Nanoliposomes by Chelating Ligands for Modulating the Neurotoxicity Associated with β-Amyloid Aggregates of Alzheimer’s disease

Cited by 20 publications

References 46 publications

In silico analytico‐mathematical interpretation of biopolymeric assemblies: Quantification of energy surfaces and molecular attributes via atomistic simulations

In silico analytico‐mathematical interpretation of biopolymeric assemblies: Quantification of energy surfaces and molecular attributes via atomistic simulations

Application of Nanodiagnostics and Nanotherapy to CNS Diseases

Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective

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