Surface engineering of nanoparticles with ligands for targeted delivery to osteosarcoma

Huang, Xin; Wu, Wei; Yang, Wenbo; Xia, Qing; Shao, Zengwu

doi:10.1016/j.colsurfb.2020.110891

Cited by 28 publications

(13 citation statements)

References 146 publications

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“…Therefore, targeted miRNA delivery platforms that improve the homing of delivery vehicles to specific tissues are being explored. Active targeting has been achieved by tethering ligands, such as saccharides, vitamins, bisphosphonate, antibodies, peptides, and aptamers, to the delivery vehicles [167,168]. For example, chemical conjugation of folic acid, a vitamin, to bacteriophage pRNA-based delivery system enables specific recognition of folate receptors that are overexpressed on the surface of cancer cells but are barely detectable on normal tissues [169].…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in miRNA Delivery Systems

Dasgupta

Chatterjee

2021

MPs

189

123

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MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that are produced in a tissue and time-specific manner to orchestrate gene expression post-transcription. MiRNAs hybridize to target mRNA(s) to induce translation repression or mRNA degradation. Functional studies have demonstrated that miRNAs are engaged in virtually every physiological process and, consequently, miRNA dysregulations have been linked to multiple human pathologies. Thus, miRNA mimics and anti-miRNAs that restore miRNA expression or downregulate aberrantly expressed miRNAs, respectively, are highly sought-after therapeutic strategies for effective manipulation of miRNA levels. In this regard, carrier vehicles that facilitate proficient and safe delivery of miRNA-based therapeutics are fundamental to the clinical success of these pharmaceuticals. Here, we highlight the strengths and weaknesses of current state-of-the-art viral and non-viral miRNA delivery systems and provide perspective on how these tools can be exploited to improve the outcomes of miRNA-based therapeutics.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in miRNA Delivery Systems

Dasgupta

Chatterjee

2021

MPs

189

123

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“…Targeting may be classified into active and passive targeting. To enhance active targeting, functionalizing nanoparticles with ligands that lead to surface interaction with overexpressed surface molecule and proteins on cancer cells, thereby facilitating cellular uptake via receptor-mediated endocytosis (Huang et al, 2020). Figure 5 illustrates the internalization of nanocarriers by the cell through receptor-mediated endocytosis by use of a targeting ligand.…”

Section: Targeted Nanocarriers and Stimuli-responsive Nanocarriersmentioning

confidence: 99%

The Application of 3D-Printing and Nanotechnology for the Targeted Treatment of Osteosarcoma

et al. 2021

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Osteosarcoma is a malignant bone neoplasm prevalent in adolescents. Current therapies include chemotherapy and surgery. Surgical resection of osteosarcoma induces a large bone defect which may be overcome by employing scaffolds for bone tissue engineering. This review details the polymers and bioceramics that may be used to fabricate 3D printed scaffolds for bone regeneration and the nanotechnology strategies that may be incorporated into such scaffolds. Natural polymers discussed include chitosan, alginate, collagen, gelatin, and silk fibroin. Synthetic polymers discussed include polycaprolactone, polyurethane, poly(lactic)acid and poly(vinyl) alcohol. Bioceramics that are utilized in bone regeneration such as calcium phosphate, calcium silicate and bioglass are elaborated on. Furthermore, comparison data between different types of 3D printed scaffolds for bone regeneration are presented. A discussion on Photo-responsive and magneto-responsive 3D printed scaffolds that have been fabricated for bone regeneration is included. Research concerning drug-loaded scaffolds as well as the incorporation of nanocarriers into scaffolds for bone regeneration is provided. Chemotherapy utilized in osteosarcoma therapy has severe adverse effects due to being non-selective between healthy cells and tumor cells. A possible way to overcome this is to utilize nanotechnology. Therefore, research detailing other types of nanocarriers that have the potential to be incorporated into 3D printed scaffolds for localized adjuvant therapy is presented.

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“…Despite advances of surgery and neoadjuvant chemotherapy during the past few decades, the overall survival rates of OS have reached a plateau [ 2 ]. However, these treatments still leave much to be improved, such as multi-drug resistance and severe side effects [ 3 ]. Therefore, there is an urgent need for the development of novel therapeutic strategies with high specificity and low toxicities to improve survival in patients with OS.…”

Section: Introductionmentioning

confidence: 99%

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Yang

Liang

et al. 2021

J Nanobiotechnol

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Background Despite advances of surgery and neoadjuvant chemotherapy during the past few decades, the therapeutic efficacy of current therapeutic protocol for osteosarcoma (OS) is still seriously compromised by multi-drug resistance and severe side effects. Amplification of intracellular oxidative stress is considered as an effective strategy to induce cancer cell death. The purpose of this study was to develop a novel strategy that can amplify the intracellular oxidative stress for synergistic cascade cancer therapy. Methods and results A novel nanocomposite, composed of folic acid (FA) modified mesoporous silica–coated gold nanostar (GNS@MSNs-FA) and traditional Chinese medicine lycorine (Ly), was rationally designed and developed. Under near-infrared (NIR) irradiation, the obtained GNS@MSNs-FA/Ly could promote a high level of ROS production via inducing mitochondrial dysfunction and potent endoplasmic reticulum (ER) stress. Moreover, glutathione (GSH) depletion during ER stress could reduce ROS scavenging and further enable efficient amplification of intracellular oxidative stress. Both in vitro and in vivo studies demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation exhibited excellent antitumor efficacy without noticeable toxicity in MNNG/HOS tumor-bearing mice. Conclusion All these results demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation could dramatically amplify the intra-tumoral oxidative stress, exhibiting excellent antitumor ability without obvious systemic toxicity. Taken together, this promising strategy provides a new avenue for the effective cancer synergetic therapy and future clinical translation.

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Surface engineering of nanoparticles with ligands for targeted delivery to osteosarcoma

Cited by 28 publications

References 146 publications

Recent Advances in miRNA Delivery Systems

Recent Advances in miRNA Delivery Systems

The Application of 3D-Printing and Nanotechnology for the Targeted Treatment of Osteosarcoma

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

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