Surface engineering of polymeric micelles for imparting multifunctionality

Advances in active targeting of ligand-directed polymeric nanomicelles via exploiting overexpressed cellular receptors for precise nanomedicine

“…3,4 Micelles with relatively low CMC are supposed to be more stable when injected into the circulation because small amounts of individual copolymers will participate in the formation of the self-assembled micelle, and hence when greatly diluted, they will resist this dilution and can preserve their micellar architecture. Moreover, the outer shell of PMs is responsible for their in vivo pharmacokinetic behavior, 5,6 besides its ability to minimize the undesired drug interactions with the surrounding environment and to reduce opsonization and uptake by the reticuloendothelial system. PMs, with their unique structure, appear to be a fascinating choice as a drug delivery owing to their unique features including; improved stability, especially upon dilution (for micelles with relatively low CMC), biocompatibility, and improved drug bioavailability.…”