Surface engineering of SPIONs: role of phosphonate ligand multivalency in tailoring their efficacy

Lam, Tina Poy Wing; Avti, Pramod K.; Pouliot, Philippe; Tardif, Jean‐Claude; Rhéaume, Éric; Lesage, Frédéric; Kakkar, Ashok

doi:10.1088/0957-4484/27/41/415602

Cited by 11 publications

(13 citation statements)

References 71 publications

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“…In these different cases of chemisorption, multivalency is an important way to increase the binding strength e.g. with bis-or triphosphonates [124,125] or with polyacids such as phosphonate end-terminated sidechains [126] or polyacrylates. The grafting-to method provides a great versatility of the surface modification as well with synthetic and natural polymers.…”

Section: Formulation Of Drugs and Magnetic Nps In Thermally Sensitivementioning

confidence: 99%

Drug releasing nanoplatforms activated by alternating magnetic fields

Mertz

Sandre

Bégin‐Colin

2017

Biochimica et Biophysica Acta (BBA) - General Subjects

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The use of an alternating magnetic field (AMF) to generate non-invasively and spatially a localized heating from a magnetic nano-mediator has become very popular these last years to develop magnetic hyperthermia (MH) as a promising therapeutic modality already used in the clinics. AMF has become highly attractive this last decade over others radiations, as AMF allows a deeper penetration in the body and a less harmful ionizing effect. In addition to pure MH which induces tumor cell death through local T elevation, this AMF-generated magneto-thermal effect can also be exploited as a relevant external stimulus to trigger a drug release from drug-loaded magnetic nanocarriers, temporally and spatially. This review article is focused especially on this concept of AMF induced drug release, possibly combined with MH. The design of such magnetically responsive drug delivery nanoplatforms requires two key and complementary components: a magnetic mediator which collects and turns the magnetic energy into local heat, and a thermoresponsive carrier ensuring thermo-induced drug release, as a consequence of magnetic stimulus. A wide panel of magnetic nanomaterials/chemistries and processes are currently developed to achieve such nanoplatforms. This review article presents a broad overview about the fundamental concepts of drug releasing nanoplatforms activated by AMF, their formulations, and their efficiency in vitro and in vivo. This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials" Guest Editors: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader.

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Section: Formulation Of Drugs and Magnetic Nps In Thermally Sensitivementioning

confidence: 99%

Drug releasing nanoplatforms activated by alternating magnetic fields

Mertz

Sandre

Bégin‐Colin

2017

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…These suggested that spherical structures were formed with a size distribution of 200 and ~60 nm, as measured by DLS and TEM respectively. As is common with solution based DLS measurements, hydrodynamic sizes of these assemblies were found to be higher as compared to TEM [37]. We were unable to obtain a critical micelle concentration of the assembled structures using pyrene encapsulation.…”

Section: Synthesismentioning

confidence: 75%

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

et al. 2020

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An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl2 catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival.

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“…The different types of IO used for the NPs synthesis include Fe3O4 (magnetite), α-Fe2O3 (hematite or antiferromagnetic), c-Fe2O3 (maghemite, ferrimagnetic), FeO (wustite, anti-ferromagnetic), γ-Fe2O3 and β-Fe2O3. However, Fe3O4 and γ-Fe2O3 NPs are the favorable and most commonly used chemical forms that are specially designed for various biomedical applications such as imaging contrast agents for MRI, thermal therapeutic tools [25,26] and as cargo vehicles due to their features of improved biocompatibility and easy formulation [27][28][29][30]. These are structurally constituted, having nanocrystalline magnetite Fe3O4 or γ-Fe2O3 with a polymeric coating.…”

Section: Iron Oxide (Io)-npsmentioning

confidence: 99%

“…can be considered to modify the surface of IONPs, i.e., organic and inorganic coatings [27]. The organic biocompatible based coating approaches are by either using a ligand exchange mechanism or physical assemblage/encapsulation [28]. Inorganic biocompatible coating involves the use of silica, Tantalum (V) Oxide.…”

Section: Fig 2: Types Of Nps and Their Multifunctional Strategiesmentioning

confidence: 99%

Tailoring the Nanoparticles Surface for Efficient Cancer Therapeutics Delivery

et al. 2020

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Nanotechnology has tremendous advantages in many areas of scientific as well as clinical research. The development of nanoparticles (NPs) that can efficiently deliver drugs specifically to the cancer cells can help reduce normal cells toxicity and co-morbidities. Cancer can be treated by exploiting the unique physiochemical of the NPs, and modulating their surface modifications using ligands which further could be used as drug cargo vehicles. To enhance biocompatibility and drug delivery towards the target site, various modifications can be included to modify the surface of the NPs, such as carbohydrates, dendrimers, DNA, RNA, siRNA, drugs, and other ligands. These ligand-coated NPs have potential applications in the field of biomedical research, including diagnosis, contrast agents for molecular and clinical imaging (Magnetic Resonance Imaging (MRI), Computed tomography (CT), positron emission tomography (PET)), as cargo vehicles for drugs, increasing the blood circulation half-life, and blood detoxification. Further, the conjugation of anti-cancer drugs to the NPs can be efficiently used to target the cancer disease. This review highlights some of the features and surface modification strategies of the NPs, such as an iron oxide (IO), liposomes (LP)-based NPs, and polymer-based NPs, which show their effectiveness as cargo agents for cancer therapeutics.

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Surface engineering of SPIONs: role of phosphonate ligand multivalency in tailoring their efficacy

Cited by 11 publications

References 71 publications

Drug releasing nanoplatforms activated by alternating magnetic fields

Drug releasing nanoplatforms activated by alternating magnetic fields

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

Tailoring the Nanoparticles Surface for Efficient Cancer Therapeutics Delivery

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