Surface-enhanced Raman probing of biomolecules using Ag-coated porous glass-ceramic substrates

Pan, Zhejun; Morgan, S. H.; Ueda, Akira; Mu, R.; Cui, Yanshan; Guo, Mingsheng; Bürger, A.; Yeh, Yung‐Hsin

doi:10.1002/jrs.1412

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…2494 www.chembiochem.org monitor the interaction of AFGP8 on HOPG and Ag-coated glass-ceramic surfaces. [72][73] A novel attempt to mimic the active domain of AFGPs in a simple monolayer design is shown in Scheme 4. A disaccharide-functionalised alkyl thiol chain was coadsorbed with C 2 H 5 OC 2 H 4 NHCOC 15 H 30 SH to form statistically mixing self-assembled monolayers on gold.…”

Section: Surface Studiesmentioning

confidence: 99%

Design and Synthesis of Antifreeze Glycoproteins and Mimics

Harding

2010

ChemBioChem

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Antifreeze glycoproteins are an important class of biological antifreezes that have potential applications in many areas of medicine, agriculture and industry in which ice crystal growth is damaging. While the synthesis of antifreeze glycoproteins as pure glycoforms has recently been achieved by using ligation and polymerisation strategies, the routine production of large quantities of pure glycoforms remains challenging. A range of C-linked analogues that are readily produced by solid-phase synthesis have delivered novel compounds that are not biological antifreezes, but are potent, non-cytotoxic, ice-recrystallisation inhibitors. Structure-activity studies, the identification of cyclic antifreeze glycoproteins and conformational studies have provided further insight into the requirements for antifreeze activity. These results, coupled with significant advances in approaches to the routine synthesis of different glycoproteins and mimics, present opportunities for the design and synthesis of novel ice-growth-inhibiting and antifreeze compounds.

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Section: Surface Studiesmentioning

confidence: 99%

Design and Synthesis of Antifreeze Glycoproteins and Mimics

Harding

2010

ChemBioChem

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“…Besides, 2D nanostructured materials deposited with noble metal NPs, such as anodic aluminum oxide layer, polymer thin films, filter paper, and porous silicon layer, are also prepared as SERS substrates. Furthermore, 3D porous structures embedded with Ag or Au NPs have also been exploited as efficient SERS substrate, such as porous polymers, porous silicon, porous alumina membranes and ceramics, and porous glass ceramics . Compared with colloid and 2D SERS substrate, it is recognized that 3D substrate can provide 3D spatial structure and larger specific surface area (SSA) for fast permeation and binding of more target analytes to form more hot spots within the laser‐illumination area, resulting in better SERS performance .…”

Section: Introductionmentioning

confidence: 99%

Porous alumina aerogel with tunable pore structure for facile, ultrasensitive, and reproducible SERS platform

Zou

Wang

Yang

et al. 2019

J Raman Spectroscopy

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Porous alumina aerogel synthesized by sol–gel method was used as facile and sensitive surface‐enhanced Raman scattering (SERS) platform. In a simple “drop‐test” SERS detection, low concentration dye solution mixed with silver nanoparticles was directly dropped on the surface of aerogel platform for SERS detection immediately. The pore structure of alumina aerogel was tuned by adding PEG‐400 and varying the gelation temperature. The effects of surface morphology and pore size of alumina aerogel platform on SERS performance of crystal violet (CV) were investigated. The result shows that large specific surface area and interconnected pore network of aerogel are helpful for fast permeation of solution, generation of “hot spots,” and adsorption of probe molecules. The Raman signal of CV was largely enhanced, enabling a detection concentration to 5 × 10−10 M with a SERS enhancement factor of 3.4 × 107. The SERS enhancement of alumina aerogel platform is remarkably improved with the increase of specific surface area and pore size, which is also confirmed by the finite‐difference time‐domain simulation. Moreover, the relative standard deviation of SERS intensity at 1619 cm-1 band for 5 × 10−8 M CV on aerogel platform is about 12%, indicating a good reproducibility.

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“…Recently, noble metal NPs have been combined with porous materials to improve their SERS performance. To fabricate SERS‐active substrates, metal NPs have been loaded onto various porous materials such as porous polymers, porous anodic alumina templates, porous silicon and porous glass‐ceramics . The inherent surface morphology of porous substrates is beneficial to the formation of hot spots.…”

Section: Introductionmentioning

confidence: 99%

“…In comparison, alumina ceramic platforms (ACPs) have potential advantages in some aspects. Firstly, similar to three‐dimensional (3‐D) structured porous polymers and porous glass‐ceramics, the ACP is a kind of volumetric material which enables fast permeation and provides enhanced analyte–metal interactions. Therefore, to perform rapid SERS, the ACPs have more reasonable potentials than two‐dimensional (2‐D) structured porous materials such as porous polymer layers, porous anodic alumina templates and porous silicon .…”

Section: Introductionmentioning

confidence: 99%

“…Thirdly, the fabrication of the ACP only involves pressing and sintering of powder materials, and the whole fabricating process takes less than 6 h, which is as simple and cost‐effective as the preparation of 2‐D structured porous materials . On the contrary, to fabricate 3‐D structured porous polymers and porous glass‐ceramics, it would take at least 1 and 10 days, respectively.…”

Section: Introductionmentioning

confidence: 99%

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A simple drop‐and‐detect method using porous alumina ceramics as platforms for rapid surface‐enhanced Raman spectroscopy

Lou

Zhao

Lin

et al. 2016

J Raman Spectroscopy

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We propose a simple and rapid surface‐enhanced Raman spectroscopy (SERS) method based on the dropping and detection of a sample droplet on a porous alumina ceramic platform (ACP). The SERS versatility of the proposed drop‐and‐detect method was demonstrated by using well‐studied water‐soluble melamine and ethanol‐soluble 4‐mercaptobenzoic acid as Raman probes. Colloidal silver nanoparticles were used as SERS substrates. Because of the fast permeation of the sample droplet by using ACPs, reproducible SERS measurements could be performed within a minute after the dropping of the sample solution. In comparison with its counterpart quartz plate, the cost‐effective ACP made the uniformity of the distribution pattern of the dried droplet improved by an order of magnitude. The measurement sensitivity was also greatly improved by using ACPs due to their enrichment functions. The lowest detectable concentrations achieved for melamine and 4‐mercaptobenzoic acid were 2.5 µg/l and 2.5 × 10−8 mol/l, respectively. The proposed drop‐and‐detect method was also demonstrated by quantitative detection of trace level melamine in liquid milk achieving a lowest detectable concentration of 0.1 mg/l, indicating its advantages of simplicity and efficiency for practical SERS applications. Copyright © 2016 John Wiley & Sons, Ltd.

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Surface-enhanced Raman probing of biomolecules using Ag-coated porous glass-ceramic substrates

Cited by 12 publications

References 28 publications

Design and Synthesis of Antifreeze Glycoproteins and Mimics

Design and Synthesis of Antifreeze Glycoproteins and Mimics

Porous alumina aerogel with tunable pore structure for facile, ultrasensitive, and reproducible SERS platform

A simple drop‐and‐detect method using porous alumina ceramics as platforms for rapid surface‐enhanced Raman spectroscopy

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