Surface-enhanced Raman scattering nanotags for bioimaging

Liu, Lin; Bi, Xinyuan; Gu, Yuqing; Wang, Fu; Ye, Jian

doi:10.1063/5.0047578

Cited by 53 publications

(28 citation statements)

References 181 publications

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“…Additionally, the recent developments in the understanding of SERS substrates (both plasmonic and nonplasmonic) and their potential have increased by leaps and bounds, the proof of which is evident from the number of review articles published in this area 196−198 Different real-world applications that can be envisaged with these SERS substrates include (a) Biomedical applications, bioimaging and biosensing 54,199,200 (b) Inspection in food quality and safety 201 (c) Biochemical and medical analysis 202 (d) Virus detection (including COVID-19) 203,204 (e) Plant disease diagnostics 205 (f) Forensics 206 Since there are numerous methods by which SERS substrates can be fabricated 207,208 it is imperative that a huge number of efforts are out to identify the niche application(s) for each one of them. For example, one may need to compromise on the cost if we need detection of femtomolar concentration of desired analyte molecule.…”

Section: Discussionmentioning

confidence: 99%

Flexible SERS substrates for hazardous materials detection: recent advances

Moram¹,

Soma²

2021

OEA

163

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This article reviews the most recent advances in the development of flexible substrates used as surface-enhanced Raman scattering (SERS) platforms for detecting several hazardous materials (e.g., explosives, pesticides, drugs, and dyes). Different flexible platforms such as papers/filter papers, fabrics, polymer nanofibers, and cellulose fibers have been investigated over the last few years and their SERS efficacies have been evaluated. We start with an introduction of the importance of hazardous materials trace detection followed by a summary of different SERS methodologies with particular attention on flexible substrates and their advantages over the nanostructures and nanoparticle-based solid/hybrid substrates. The potential of flexible SERS substrates, in conjunction with a simple portable Raman spectrometer, is the power to enable practical/on-field/point of interest applications primarily because of their low-cost and easy sampling.

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Section: Discussionmentioning

confidence: 99%

Flexible SERS substrates for hazardous materials detection: recent advances

Moram¹,

Soma²

2021

OEA

163

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“…2 A). CM mechanism, though not fully understood so far, often refers to (i) the increased polarizability of the molecules, (ii) molecular electronic excitation promoted by the photon excitation, or (iii) charge transfer transitions between the metal and molecules [ 64 , 65 ]. It is usually effective for a molecule that directly contacts nanostructure surface, especially via chemo-adsorption.…”

Section: Main Metabolic Molecules Detecting Methodsmentioning

confidence: 99%

“…A variety of SERS NPs coated with different targeting ligands have been developed, benefiting SERS-based multiplexing analysis [ 75 , 76 ]. SERS NPs possesses great potentials in bioimaging, immunoassay, microtumor diagnosis, as well as intraoperative navigation [ 64 , [77] , [78] , [79] , [80] ].…”

Section: Main Metabolic Molecules Detecting Methodsmentioning

confidence: 99%

Human metabolite detection by surface-enhanced Raman spectroscopy

Liu

2022

Materials Today Bio

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Metabolites are important biomarkers in human body fluids, conveying direct information of cellular activities and physical conditions. Metabolite detection has long been a research hotspot in the field of biology and medicine. Surface-enhanced Raman spectroscopy (SERS), based on the molecular “fingerprint” of Raman spectrum and the enormous signal enhancement (down to a single-molecule level) by plasmonic nanomaterials, has proven to be a novel and powerful tool for metabolite detection. SERS provides favorable properties such as ultra-sensitive, label-free, rapid, specific, and non-destructive detection processes. In this review, we summarized the progress in recent 10 years on SERS-based sensing of endogenous metabolites at the cellular level, in tissues, and in biofluids, as well as drug metabolites in biofluids. We made detailed discussions on the challenges and optimization methods of SERS technique in metabolite detection. The combination of SERS with modern biomedical technology were also anticipated.

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“…SERS spectra should be collected upon irradiation with an excitation wavelength that is harmless to cells and, ideally, that can propagate through tissue, typically within the first biological transparency window, between 680 and 920 nm. 107 , 108 Modulation of plasmon resonances has been primarily realized by varying either the chemical nature or the morphology of the nanostructured plasmonic component (the NP). 109 − 111 Other strategies can be used to dynamically dictate plasmon resonances based on the application of external electrical, 112 magnetic, 113 thermal, 114 or light stimuli.…”

Section: Substrate Fabrication and Sers Enhancement Optimizationmentioning

confidence: 99%

Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine

et al. 2022

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Future precision medicine will be undoubtedly sustained by the detection of validated biomarkers that enable a precise classification of patients based on their predicted disease risk, prognosis, and response to a specific treatment. Up to now, genomics, transcriptomics, and immunohistochemistry have been the main clinically amenable tools at hand for identifying key diagnostic, prognostic, and predictive biomarkers. However, other molecular strategies, including metabolomics, are still in their infancy and require the development of new biomarker detection technologies, toward routine implementation into clinical diagnosis. In this context, surface-enhanced Raman scattering (SERS) spectroscopy has been recognized as a promising technology for clinical monitoring thanks to its high sensitivity and label-free operation, which should help accelerate the discovery of biomarkers and their corresponding screening in a simpler, faster, and less-expensive manner. Many studies have demonstrated the excellent performance of SERS in biomedical applications. However, such studies have also revealed several variables that should be considered for accurate SERS monitoring, in particular, when the signal is collected from biological sources (tissues, cells or biofluids). This Perspective is aimed at piecing together the puzzle of SERS in biomarker monitoring, with a view on future challenges and implications. We address the most relevant requirements of plasmonic substrates for biomedical applications, as well as the implementation of tools from artificial intelligence or biotechnology to guide the development of highly versatile sensors.

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Surface-enhanced Raman scattering nanotags for bioimaging

Cited by 53 publications

References 181 publications

Flexible SERS substrates for hazardous materials detection: recent advances

Flexible SERS substrates for hazardous materials detection: recent advances

Human metabolite detection by surface-enhanced Raman spectroscopy

Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine

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