Surface Enhanced Raman Spectroscopy Based Biosensor with a Microneedle Array for Minimally Invasive <i>In Vivo</i> Glucose Measurements

Ju, Jian; Hsieh, Chao-Mao; Tian, Yao; Kang, Julian; Chia, Rui Ning; Chang, Hao; Bai, Yanru; Xu, Chen; Wang, Xiaomeng; Liu, Quan

doi:10.1021/acssensors.0c00444

Cited by 91 publications

(67 citation statements)

References 58 publications

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“…In another work, NOA MNs were functionalised with plasmonically active gold nanorods and covered with the pH-sensitive molecule 4-mercaptobenzoic acid to use in Surface Enhanced Raman Spectroscopy (SERS) [95]. SERS was implemented with PMMA MN coated by silver nanoparticles and functionalised with 1-decanethiol [96]. The PMMA MN array was prepared using a stainless-steel master mould.…”

Section: Casting Methodsmentioning

confidence: 99%

“…Solid MNs were generally functionalised to serve as bio-electrodes and sometimes to punch the skin [91]. The fabrication techniques that were reported for producing solid MNs are 1) casting [82,[92][93][94][95][96][97][98][99][100][101]; 2) injection moulding [83,[102][103][104][105][106][107], Figure 3A; 3) DRIE [84,[108][109][110], Figure 3B, and 4) wet chemical etchant [85,111], Figure 3C. Solid MNs for ISF sampling were also fabricated using infrared laser [112] and lithographically defined chemical etching [113].…”

Section: Solid Mnsmentioning

confidence: 99%

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Microneedle Arrays for Sampling and Sensing Dermal Interstitial Fluid

Kashaninejad¹,

Munaz²,

Moghadas³

et al. 2021

Preprint

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Dermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo extraction and analysis of ISF are challenging. On the other hand, microneedle (MN) technology can address most of the challenges associated with dermal ISF extraction and is well-suited for long-term, continuous ISF monitoring as well as in situ detection. In this review, we first briefly summarise the different dermal ISF collection methods and compare them with MN methods. Next, we elaborate on the design considerations and biocompatibility of MNs. Subsequently, the fabrication technologies of various MNs used for dermal ISF extraction, including solid MNs, hollow MNs, porous MNs and hydrogel MNs, are thoroughly explained. In addition, different sensing mechanisms of ISF detection will be discussed in detail. Subsequently, we identify the challenges and propose the possible solutions associated with ISF extraction. A detailed investigation is provided for the transport and sampling mechanism of ISF in vivo. Also, the current in vitro skin model integrated with the MN arrays will be discussed. Finally, future directions to develop a point-of-care (POC) device to sample ISF are proposed.

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Section: Casting Methodsmentioning

confidence: 99%

Section: Solid Mnsmentioning

confidence: 99%

Microneedle Arrays for Sampling and Sensing Dermal Interstitial Fluid

Kashaninejad¹,

Munaz²,

Moghadas³

et al. 2021

Preprint

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show abstract

“…Sharma et al 137 , however, reported that their device with a PP film required application for an hour to allow the sensor to equilibrate with ISF and achieve a stable baseline before readings could be taken. Surface-enhanced Raman spectroscopy (SERS) has also been used in conjunction with solid metal-coated microneedles for the in-situ detection of glucose, pH and the hemozoin, a metabolite of haemoglobin produced by malaria parasites in infected erythrocytes 137 , 146 , 147 , 148 . The mechanism of SERS is apparently related to the frequency of monochromatic light changes on a surface based on the interactions with a molecule where the resulting signal is subsequently enhanced using metal nanoparticles 149 .…”

Section: Microneedle Diagnostic Platformsmentioning

confidence: 99%

Microneedle-based devices for point-of-care infectious disease diagnostics

Dixon

Skaria

Lau

et al. 2021

Acta Pharmaceutica Sinica B

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Recent infectious disease outbreaks, such as COVID-19 and Ebola, have highlighted the need for rapid and accurate diagnosis to initiate treatment and curb transmission. Successful diagnostic strategies critically depend on the efficiency of biological sampling and timely analysis. However, current diagnostic techniques are invasive/intrusive and present a severe bottleneck by requiring specialist equipment and trained personnel. Moreover, centralised test facilities are poorly accessible and the requirement to travel may increase disease transmission. Self-administrable, point-of-care (PoC) microneedle diagnostic devices could provide a viable solution to these problems. These miniature needle arrays can detect biomarkers in/from the skin in a minimally invasive manner to provide (near-) real-time diagnosis. Few microneedle devices have been developed specifically for infectious disease diagnosis, though similar technologies are well established in other fields and generally adaptable for infectious disease diagnosis. These include microneedles for biofluid extraction, microneedle sensors and analyte-capturing microneedles, or combinations thereof. Analyte sampling/detection from both blood and dermal interstitial fluid is possible. These technologies are in their early stages of development for infectious disease diagnostics, and there is a vast scope for further development. In this review, we discuss the utility and future outlook of these microneedle technologies in infectious disease diagnosis.

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“…62 To improve the extraction and detection efficiencies, MNs with novel microstructures or materials can be prepared by a multi-step process. [63][64][65][66][67] For example, Mandal et al designed a MN patch with a core-shell structure for longitudinal sampling of cells and skin ISF. The group rst fabricated polylactic acid (PLA) MN arrays through PDMS molds and subsequently coated them with polylysine, alginate, and sucrose mixtures.…”

Section: Design and Fabrication Strategies Of Mnsmentioning

confidence: 99%