We have produced isotopically enriched ZnO nanorods using Zn-enriched ZnO source powder by vapour phase transport on silicon substrates buffer-coated with unenriched ZnO seed layers. SEM and XRD data confirm successful growth of high quality, dense, c-axis aligned nanorods over a substantial surface area. Raman data show a shift of >1 cm -1 in the peak position of the Raman scattered peaks due to the E 2 low and E 2 high phonon modes when the Zn isotope is changed from 64 Zn to 68 Zn, consistent with previous work, thus confirming successful isotopic enrichment. SIMS data provides additional confirmation of enrichment.The optical quality (as determined by photoluminescence feature intensity and linewidth) is excellent. Samples with Zn isotopic enrichment ranging from 64 ZnO to 68 ZnO display a shift in recombination energy of the bound excitons at the band edge (3.34 -3.37 eV) of ~ 0.6 meV. This blue shift is also consistent with previously published data, further confirming *Manuscript Revised Click here to view linked References 2 both the excellent optical quality and successful isotopic substitution of ZnO nanorods using this relatively simple growth method.